Lorcaserin Inhibit Glucose-Stimulated Insulin Secretion and Calcium Influx in Murine Pancreatic Islets

Lorcaserin Inhibit Glucose-Stimulated Insulin Secretion and Calcium Influx in Murine Pancreatic Islets

Lorcaserin is a serotonergic agonist specific to the 5-hydroxytryptamine 2c receptor (5-HT2CR) that is FDA approved for the long-term management of obesity with or without at least one weight-related comorbidity. Lorcaserin can restrain patients’ appetite and improve insulin sensitivity and hyperins...

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Bibliographic Details
Main Authors: Muhan Jing, Shanshan Wang, Ding Li, Zeyu Wang, Ziwen Li, Yichen Lu, Tong Sun, Chen Qiu, Fang Chen, Haijuan Yu, Wei Zhang
Format: article
Language:EN
Published: Frontiers Media S.A. 2021
Subjects:
lorcaserin
glucose-stimulated insulin secretion
beta cell
5-HT 2C R
obesity
type 2 diabetes mellitus
Therapeutics. Pharmacology
RM1-950
Online Access:https://doaj.org/article/adfc739abd40432680c62a204c56bcf9
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https://doaj.org/article/adfc739abd40432680c62a204c56bcf9

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