Nuclear S-nitrosylation impacts tissue regeneration in zebrafish

The role of the post-translational modifications in tissue regeneration is still not clearly understood. Here, the authors show that many nuclear proteins change S-nitrosylation state in the regenerating zebrafish tailfin, highlighting the importance of Kdm1a S-nitrosylation in the repair process.

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Auteurs principaux: Gianfranco Matrone, Sung Yun Jung, Jong Min Choi, Antrix Jain, Hon-Chiu Eastwood Leung, Kimal Rajapakshe, Cristian Coarfa, Julie Rodor, Martin A. Denvir, Andrew H. Baker, John P. Cooke
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Accès en ligne:https://doaj.org/article/adfe028e44264c2b8db2eceb6959bc23
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Résumé:The role of the post-translational modifications in tissue regeneration is still not clearly understood. Here, the authors show that many nuclear proteins change S-nitrosylation state in the regenerating zebrafish tailfin, highlighting the importance of Kdm1a S-nitrosylation in the repair process.