Clinical evaluation of a newly developed graft inserter (NS Endo-Inserter) for Descemet stripping automated endothelial keratoplasty

Takeshi Soma,1 Shizuka Koh,1,2 Yoshinori Oie,1 Kazuichi Maruyama,1,2 Motokazu Tsujikawa,1 Satoshi Kawasaki,1 Naoyuki Maeda,1 Kohji Nishida1 1Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan; 2Department of Innovative Visual Science, Osaka University, Gr...

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Autores principales:	Soma T, Koh S, Oie Y, Maruyama K, Tsujikawa M, Kawasaki S, Maeda N, Nishida K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Corneal endothelial transplantation Clinical evaluation of new technique Endothelial cell damage Graft attachment Safety Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/ae01a0a8398d4537927e7dcd483e9cea
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spelling	oai:doaj.org-article:ae01a0a8398d4537927e7dcd483e9cea2021-12-02T06:27:51ZClinical evaluation of a newly developed graft inserter (NS Endo-Inserter) for Descemet stripping automated endothelial keratoplasty1177-5483https://doaj.org/article/ae01a0a8398d4537927e7dcd483e9cea2018-12-01T00:00:00Zhttps://www.dovepress.com/clinical-evaluation-of-a-newly-developed-graft-inserter-ns-endo-insert-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Takeshi Soma,1 Shizuka Koh,1,2 Yoshinori Oie,1 Kazuichi Maruyama,1,2 Motokazu Tsujikawa,1 Satoshi Kawasaki,1 Naoyuki Maeda,1 Kohji Nishida1 1Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan; 2Department of Innovative Visual Science, Osaka University, Graduate School of Medicine, Suita, Osaka, Japan Purpose: The aim of this study was to describe the postoperative outcomes of Descemet stripping automated endothelial keratoplasty (DSAEK) performed using our newly developed graft inserter (NS Endo-Inserter) and compare the findings with those for DSAEK performed using the Busin glide. Patients and methods: In this retrospective, case-control, institutional study, we studied the clinical outcomes of DSAEK performed using the NS Endo-Inserter (NS group, n=13) or the Busin glide (Busin group, n=10) for patients with corneal endothelial dysfunction. Clinical parameters, including the distance-corrected visual acuity (DCVA), endothelial cell (EC) loss, and intraoperative/postoperative complications, were assessed over a 6-month follow-up period. Results: At 6 months after surgery, the mean DCVA showed no significant difference between the two groups. EC loss at 3 and 6 months after DSAEK was 9.1%±20.7% and 18.2%±22.6%, respectively, in the NS group and 44.0%±25.5% and 46.5%±23.3%, respectively, in the Busin group; differences between groups were statistically significant at both 3 and 6 months (P=0.024 and P=0.016, respectively). Anterior chamber hemorrhage was observed in one patient in the Busin group. Rebubbling after surgery was required for one eye in the Busin group. No complications were observed in the NS group. Conclusion: Our newly developed graft inserter for DSAEK may cause significantly less EC damage than the conventional pull-through technique using the Busin glide. Our inserter permits safe endothelial graft delivery without anterior chamber collapse and can result in successful graft attachment without complications at 6 months after surgery. Keywords: corneal endothelial transplantation, clinical evaluation of new technique, endothelial cell damage, graft attachment, safetySoma TKoh SOie YMaruyama KTsujikawa MKawasaki SMaeda NNishida KDove Medical PressarticleCorneal endothelial transplantationClinical evaluation of new techniqueEndothelial cell damageGraft attachmentSafetyOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 13, Pp 43-48 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Corneal endothelial transplantation Clinical evaluation of new technique Endothelial cell damage Graft attachment Safety Ophthalmology RE1-994
spellingShingle	Corneal endothelial transplantation Clinical evaluation of new technique Endothelial cell damage Graft attachment Safety Ophthalmology RE1-994 Soma T Koh S Oie Y Maruyama K Tsujikawa M Kawasaki S Maeda N Nishida K Clinical evaluation of a newly developed graft inserter (NS Endo-Inserter) for Descemet stripping automated endothelial keratoplasty
description	Takeshi Soma,1 Shizuka Koh,1,2 Yoshinori Oie,1 Kazuichi Maruyama,1,2 Motokazu Tsujikawa,1 Satoshi Kawasaki,1 Naoyuki Maeda,1 Kohji Nishida1 1Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan; 2Department of Innovative Visual Science, Osaka University, Graduate School of Medicine, Suita, Osaka, Japan Purpose: The aim of this study was to describe the postoperative outcomes of Descemet stripping automated endothelial keratoplasty (DSAEK) performed using our newly developed graft inserter (NS Endo-Inserter) and compare the findings with those for DSAEK performed using the Busin glide. Patients and methods: In this retrospective, case-control, institutional study, we studied the clinical outcomes of DSAEK performed using the NS Endo-Inserter (NS group, n=13) or the Busin glide (Busin group, n=10) for patients with corneal endothelial dysfunction. Clinical parameters, including the distance-corrected visual acuity (DCVA), endothelial cell (EC) loss, and intraoperative/postoperative complications, were assessed over a 6-month follow-up period. Results: At 6 months after surgery, the mean DCVA showed no significant difference between the two groups. EC loss at 3 and 6 months after DSAEK was 9.1%±20.7% and 18.2%±22.6%, respectively, in the NS group and 44.0%±25.5% and 46.5%±23.3%, respectively, in the Busin group; differences between groups were statistically significant at both 3 and 6 months (P=0.024 and P=0.016, respectively). Anterior chamber hemorrhage was observed in one patient in the Busin group. Rebubbling after surgery was required for one eye in the Busin group. No complications were observed in the NS group. Conclusion: Our newly developed graft inserter for DSAEK may cause significantly less EC damage than the conventional pull-through technique using the Busin glide. Our inserter permits safe endothelial graft delivery without anterior chamber collapse and can result in successful graft attachment without complications at 6 months after surgery. Keywords: corneal endothelial transplantation, clinical evaluation of new technique, endothelial cell damage, graft attachment, safety
format	article
author	Soma T Koh S Oie Y Maruyama K Tsujikawa M Kawasaki S Maeda N Nishida K
author_facet	Soma T Koh S Oie Y Maruyama K Tsujikawa M Kawasaki S Maeda N Nishida K
author_sort	Soma T
title	Clinical evaluation of a newly developed graft inserter (NS Endo-Inserter) for Descemet stripping automated endothelial keratoplasty
title_short	Clinical evaluation of a newly developed graft inserter (NS Endo-Inserter) for Descemet stripping automated endothelial keratoplasty
title_full	Clinical evaluation of a newly developed graft inserter (NS Endo-Inserter) for Descemet stripping automated endothelial keratoplasty
title_fullStr	Clinical evaluation of a newly developed graft inserter (NS Endo-Inserter) for Descemet stripping automated endothelial keratoplasty
title_full_unstemmed	Clinical evaluation of a newly developed graft inserter (NS Endo-Inserter) for Descemet stripping automated endothelial keratoplasty
title_sort	clinical evaluation of a newly developed graft inserter (ns endo-inserter) for descemet stripping automated endothelial keratoplasty
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/ae01a0a8398d4537927e7dcd483e9cea
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Clinical evaluation of a newly developed graft inserter (NS Endo-Inserter) for Descemet stripping automated endothelial keratoplasty

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