Biased localization of actin binding proteins by actin filament conformation

The assembly of actin filaments into distinct cytoskeletal structures plays a critical role in cell physiology. Here, the authors use a combination of live cell imaging and in vitro single molecule binding measurements to show that tandem calponin homology domains (CH1–CH2) are sensitive to actin fi...

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Autores principales:	Andrew R. Harris, Pamela Jreij, Brian Belardi, Aaron M. Joffe, Andreas R. Bausch, Daniel A. Fletcher
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ae02da38c3004ec79edd58117dec2542
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spelling	oai:doaj.org-article:ae02da38c3004ec79edd58117dec25422021-12-02T13:27:23ZBiased localization of actin binding proteins by actin filament conformation10.1038/s41467-020-19768-92041-1723https://doaj.org/article/ae02da38c3004ec79edd58117dec25422020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19768-9https://doaj.org/toc/2041-1723The assembly of actin filaments into distinct cytoskeletal structures plays a critical role in cell physiology. Here, the authors use a combination of live cell imaging and in vitro single molecule binding measurements to show that tandem calponin homology domains (CH1–CH2) are sensitive to actin filament conformation, biasing their subcellular localization.Andrew R. HarrisPamela JreijBrian BelardiAaron M. JoffeAndreas R. BauschDaniel A. FletcherNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Andrew R. Harris Pamela Jreij Brian Belardi Aaron M. Joffe Andreas R. Bausch Daniel A. Fletcher Biased localization of actin binding proteins by actin filament conformation
description	The assembly of actin filaments into distinct cytoskeletal structures plays a critical role in cell physiology. Here, the authors use a combination of live cell imaging and in vitro single molecule binding measurements to show that tandem calponin homology domains (CH1–CH2) are sensitive to actin filament conformation, biasing their subcellular localization.
format	article
author	Andrew R. Harris Pamela Jreij Brian Belardi Aaron M. Joffe Andreas R. Bausch Daniel A. Fletcher
author_facet	Andrew R. Harris Pamela Jreij Brian Belardi Aaron M. Joffe Andreas R. Bausch Daniel A. Fletcher
author_sort	Andrew R. Harris
title	Biased localization of actin binding proteins by actin filament conformation
title_short	Biased localization of actin binding proteins by actin filament conformation
title_full	Biased localization of actin binding proteins by actin filament conformation
title_fullStr	Biased localization of actin binding proteins by actin filament conformation
title_full_unstemmed	Biased localization of actin binding proteins by actin filament conformation
title_sort	biased localization of actin binding proteins by actin filament conformation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/ae02da38c3004ec79edd58117dec2542
work_keys_str_mv	AT andrewrharris biasedlocalizationofactinbindingproteinsbyactinfilamentconformation AT pamelajreij biasedlocalizationofactinbindingproteinsbyactinfilamentconformation AT brianbelardi biasedlocalizationofactinbindingproteinsbyactinfilamentconformation AT aaronmjoffe biasedlocalizationofactinbindingproteinsbyactinfilamentconformation AT andreasrbausch biasedlocalizationofactinbindingproteinsbyactinfilamentconformation AT danielafletcher biasedlocalizationofactinbindingproteinsbyactinfilamentconformation
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Biased localization of actin binding proteins by actin filament conformation

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