Pathogenicity & virulence of Mycoplasma hyopneumoniae

Mycoplasma hyopneumoniae: is the etiological agent of porcine enzootic pneumonia (EP), a disease that impacts the swine industry worldwide. Pathogen-induced damage, as well as the elicited host-response, contribute to disease. Here, we provide an overview of EP epidemiology, control and prevention,...

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Autores principales:	Fernanda M. A. Leal Zimmer, Jéssica Andrade Paes, Arnaldo Zaha, Henrique Bunselmeyer Ferreira
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2020
Materias:	mycoplasma hyopneumoniae porcine enzootic pneumonia pathogenicity virulence factors host response Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/ae0322c69f454b4cae0961e4e7d5fd4e
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spelling	oai:doaj.org-article:ae0322c69f454b4cae0961e4e7d5fd4e2021-11-17T14:21:59ZPathogenicity & virulence of Mycoplasma hyopneumoniae2150-55942150-560810.1080/21505594.2020.1842659https://doaj.org/article/ae0322c69f454b4cae0961e4e7d5fd4e2020-12-01T00:00:00Zhttp://dx.doi.org/10.1080/21505594.2020.1842659https://doaj.org/toc/2150-5594https://doaj.org/toc/2150-5608Mycoplasma hyopneumoniae: is the etiological agent of porcine enzootic pneumonia (EP), a disease that impacts the swine industry worldwide. Pathogen-induced damage, as well as the elicited host-response, contribute to disease. Here, we provide an overview of EP epidemiology, control and prevention, and a more in-depth review of M. hyopneumoniae pathogenicity determinants, highlighting some molecular mechanisms of pathogen-host interactions relevant for pathogenesis. Based on recent functional, immunological, and comparative “omics” results, we discuss the roles of many known or putative M. hyopneumoniae virulence factors, along with host molecules involved in EP. Moreover, the known molecular bases of pathogenicity mechanisms, including M. hyopneumoniae adhesion to host respiratory epithelium, protein secretion, cell damage, host microbicidal response and its modulation, and maintenance of M. hyopneumoniae homeostasis during infection are described. Recent findings regarding M. hyopneumoniae pathogenicity determinants also contribute to the development of novel diagnostic tests, vaccines, and treatments for EP.Fernanda M. A. Leal ZimmerJéssica Andrade PaesArnaldo ZahaHenrique Bunselmeyer FerreiraTaylor & Francis Grouparticlemycoplasma hyopneumoniaeporcine enzootic pneumoniapathogenicityvirulence factorshost responseInfectious and parasitic diseasesRC109-216ENVirulence, Vol 11, Iss 1, Pp 1600-1622 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	mycoplasma hyopneumoniae porcine enzootic pneumonia pathogenicity virulence factors host response Infectious and parasitic diseases RC109-216
spellingShingle	mycoplasma hyopneumoniae porcine enzootic pneumonia pathogenicity virulence factors host response Infectious and parasitic diseases RC109-216 Fernanda M. A. Leal Zimmer Jéssica Andrade Paes Arnaldo Zaha Henrique Bunselmeyer Ferreira Pathogenicity & virulence of Mycoplasma hyopneumoniae
description	Mycoplasma hyopneumoniae: is the etiological agent of porcine enzootic pneumonia (EP), a disease that impacts the swine industry worldwide. Pathogen-induced damage, as well as the elicited host-response, contribute to disease. Here, we provide an overview of EP epidemiology, control and prevention, and a more in-depth review of M. hyopneumoniae pathogenicity determinants, highlighting some molecular mechanisms of pathogen-host interactions relevant for pathogenesis. Based on recent functional, immunological, and comparative “omics” results, we discuss the roles of many known or putative M. hyopneumoniae virulence factors, along with host molecules involved in EP. Moreover, the known molecular bases of pathogenicity mechanisms, including M. hyopneumoniae adhesion to host respiratory epithelium, protein secretion, cell damage, host microbicidal response and its modulation, and maintenance of M. hyopneumoniae homeostasis during infection are described. Recent findings regarding M. hyopneumoniae pathogenicity determinants also contribute to the development of novel diagnostic tests, vaccines, and treatments for EP.
format	article
author	Fernanda M. A. Leal Zimmer Jéssica Andrade Paes Arnaldo Zaha Henrique Bunselmeyer Ferreira
author_facet	Fernanda M. A. Leal Zimmer Jéssica Andrade Paes Arnaldo Zaha Henrique Bunselmeyer Ferreira
author_sort	Fernanda M. A. Leal Zimmer
title	Pathogenicity & virulence of Mycoplasma hyopneumoniae
title_short	Pathogenicity & virulence of Mycoplasma hyopneumoniae
title_full	Pathogenicity & virulence of Mycoplasma hyopneumoniae
title_fullStr	Pathogenicity & virulence of Mycoplasma hyopneumoniae
title_full_unstemmed	Pathogenicity & virulence of Mycoplasma hyopneumoniae
title_sort	pathogenicity & virulence of mycoplasma hyopneumoniae
publisher	Taylor & Francis Group
publishDate	2020
url	https://doaj.org/article/ae0322c69f454b4cae0961e4e7d5fd4e
work_keys_str_mv	AT fernandamalealzimmer pathogenicityvirulenceofmycoplasmahyopneumoniae AT jessicaandradepaes pathogenicityvirulenceofmycoplasmahyopneumoniae AT arnaldozaha pathogenicityvirulenceofmycoplasmahyopneumoniae AT henriquebunselmeyerferreira pathogenicityvirulenceofmycoplasmahyopneumoniae
_version_	1718425436608790528

Pathogenicity & virulence of Mycoplasma hyopneumoniae

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