Low FT3 is an independent marker of disease severity in patients hospitalized for COVID-19

Aim: To study the prevalence of thyroid dysfunction and its association with disease severity in hospitalized patients of coronavirus disease-19 (COVID-19). Methods: In this retrospective cohort study, thyroid function tests (TFT) of 236 hospitalized patients of COVID-19 along with demographic, co...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Aditya Dutta, Ganesh Jevalikar, Rutuja Sharma, Khalid J Farooqui, Shama Mahendru, Arun Dewan, Sandeep Bhudiraja, Ambrish Mithal
Formato:	article
Lenguaje:	EN
Publicado:	Bioscientifica 2021
Materias:	covid-19 hypothyroidism low ft3 non-thyroidal illness severity Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doi.org/10.1530/EC-21-0362 https://doaj.org/article/ae032ea781e847eba709da19da5643e7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ae032ea781e847eba709da19da5643e7
record_format	dspace
spelling	oai:doaj.org-article:ae032ea781e847eba709da19da5643e72021-11-16T06:37:17ZLow FT3 is an independent marker of disease severity in patients hospitalized for COVID-19https://doi.org/10.1530/EC-21-03622049-3614https://doaj.org/article/ae032ea781e847eba709da19da5643e72021-11-01T00:00:00Zhttps://ec.bioscientifica.com/view/journals/ec/10/11/EC-21-0362.xmlhttps://doaj.org/toc/2049-3614Aim: To study the prevalence of thyroid dysfunction and its association with disease severity in hospitalized patients of coronavirus disease-19 (COVID-19). Methods: In this retrospective cohort study, thyroid function tests (TFT) of 236 hospitalized patients of COVID-19 along with demographic, comorbid, clinical, biochemical and disease severity records were analysed. Patients were divided into previous euthyroid or hypothyroid status to observe the effect o f prior hypothyroidism on the severity of COVID-19. Results: TFT abnormalities were common. Low free T3 (FT3), high thyroid-stimulating hormone (TSH) and low TSH were seen in 56 (23.7%), 15 (6.4%) and 9 (3.8%) patients, respectively. The median levels of TSH (2.06 vs 1.26 mIU/mL, P = 0.001) and FT3 (2.94 vs 2.47 pg/mL, P < 0.001) were significantly lower in severe disease. Previous h ypothyroid status (n = 43) was associated with older age, higher frequency of comorbidities, higher FT4 and lower FT3. TFT did not correlate with markers of inflamm ation (except lactate dehydrogenase); however, FT3 and TSH negatively correlated with outcome severity score and duration of hospital stay. Cox regression analysis showed that low FT3 was associated with severe COVID-19 (P = 0.032, HR 0.302; CI 0.101–0.904), irrespective of prior hypothyroidism. Conclusions: Functional thyroid abnormalities (low FT3 and low TSH) are fre quently seen in hospitalized patients of COVID-19. Although these abnormalities did not correlate with markers of inflammation, this study shows that low FT3 at a dmission independently predicts the severity of COVID-19. Aditya DuttaGanesh JevalikarRutuja SharmaKhalid J FarooquiShama MahendruArun DewanSandeep BhudirajaAmbrish MithalBioscientificaarticlecovid-19hypothyroidismlow ft3non-thyroidal illnessseverityDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENEndocrine Connections, Vol 10, Iss 11, Pp 1455-1462 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	covid-19 hypothyroidism low ft3 non-thyroidal illness severity Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	covid-19 hypothyroidism low ft3 non-thyroidal illness severity Diseases of the endocrine glands. Clinical endocrinology RC648-665 Aditya Dutta Ganesh Jevalikar Rutuja Sharma Khalid J Farooqui Shama Mahendru Arun Dewan Sandeep Bhudiraja Ambrish Mithal Low FT3 is an independent marker of disease severity in patients hospitalized for COVID-19
description	Aim: To study the prevalence of thyroid dysfunction and its association with disease severity in hospitalized patients of coronavirus disease-19 (COVID-19). Methods: In this retrospective cohort study, thyroid function tests (TFT) of 236 hospitalized patients of COVID-19 along with demographic, comorbid, clinical, biochemical and disease severity records were analysed. Patients were divided into previous euthyroid or hypothyroid status to observe the effect o f prior hypothyroidism on the severity of COVID-19. Results: TFT abnormalities were common. Low free T3 (FT3), high thyroid-stimulating hormone (TSH) and low TSH were seen in 56 (23.7%), 15 (6.4%) and 9 (3.8%) patients, respectively. The median levels of TSH (2.06 vs 1.26 mIU/mL, P = 0.001) and FT3 (2.94 vs 2.47 pg/mL, P < 0.001) were significantly lower in severe disease. Previous h ypothyroid status (n = 43) was associated with older age, higher frequency of comorbidities, higher FT4 and lower FT3. TFT did not correlate with markers of inflamm ation (except lactate dehydrogenase); however, FT3 and TSH negatively correlated with outcome severity score and duration of hospital stay. Cox regression analysis showed that low FT3 was associated with severe COVID-19 (P = 0.032, HR 0.302; CI 0.101–0.904), irrespective of prior hypothyroidism. Conclusions: Functional thyroid abnormalities (low FT3 and low TSH) are fre quently seen in hospitalized patients of COVID-19. Although these abnormalities did not correlate with markers of inflammation, this study shows that low FT3 at a dmission independently predicts the severity of COVID-19.
format	article
author	Aditya Dutta Ganesh Jevalikar Rutuja Sharma Khalid J Farooqui Shama Mahendru Arun Dewan Sandeep Bhudiraja Ambrish Mithal
author_facet	Aditya Dutta Ganesh Jevalikar Rutuja Sharma Khalid J Farooqui Shama Mahendru Arun Dewan Sandeep Bhudiraja Ambrish Mithal
author_sort	Aditya Dutta
title	Low FT3 is an independent marker of disease severity in patients hospitalized for COVID-19
title_short	Low FT3 is an independent marker of disease severity in patients hospitalized for COVID-19
title_full	Low FT3 is an independent marker of disease severity in patients hospitalized for COVID-19
title_fullStr	Low FT3 is an independent marker of disease severity in patients hospitalized for COVID-19
title_full_unstemmed	Low FT3 is an independent marker of disease severity in patients hospitalized for COVID-19
title_sort	low ft3 is an independent marker of disease severity in patients hospitalized for covid-19
publisher	Bioscientifica
publishDate	2021
url	https://doi.org/10.1530/EC-21-0362 https://doaj.org/article/ae032ea781e847eba709da19da5643e7
work_keys_str_mv	AT adityadutta lowft3isanindependentmarkerofdiseaseseverityinpatientshospitalizedforcovid19 AT ganeshjevalikar lowft3isanindependentmarkerofdiseaseseverityinpatientshospitalizedforcovid19 AT rutujasharma lowft3isanindependentmarkerofdiseaseseverityinpatientshospitalizedforcovid19 AT khalidjfarooqui lowft3isanindependentmarkerofdiseaseseverityinpatientshospitalizedforcovid19 AT shamamahendru lowft3isanindependentmarkerofdiseaseseverityinpatientshospitalizedforcovid19 AT arundewan lowft3isanindependentmarkerofdiseaseseverityinpatientshospitalizedforcovid19 AT sandeepbhudiraja lowft3isanindependentmarkerofdiseaseseverityinpatientshospitalizedforcovid19 AT ambrishmithal lowft3isanindependentmarkerofdiseaseseverityinpatientshospitalizedforcovid19
_version_	1718426688119898112

Low FT3 is an independent marker of disease severity in patients hospitalized for COVID-19

Ejemplares similares