Predictive design of sigma factor-specific promoters
Automated design tools and tailored subunits are beneficial in fine-tuning all components of a complex genetic circuit. Here the authors create E. coli and B. subtilis promoter libraries using FACS and HTS, from which an online promoter design tool has been developed using CNN.
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Nature Portfolio
2020
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oai:doaj.org-article:ae04ea037b8d404a8d08ac51c6a9e3ae2021-12-02T17:32:58ZPredictive design of sigma factor-specific promoters10.1038/s41467-020-19446-w2041-1723https://doaj.org/article/ae04ea037b8d404a8d08ac51c6a9e3ae2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19446-whttps://doaj.org/toc/2041-1723Automated design tools and tailored subunits are beneficial in fine-tuning all components of a complex genetic circuit. Here the authors create E. coli and B. subtilis promoter libraries using FACS and HTS, from which an online promoter design tool has been developed using CNN.Maarten Van BremptJim ClauwaertFriederike MeyMichiel StockJo MaertensWillem WaegemanMarjan De MeyNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020) |
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Science Q Maarten Van Brempt Jim Clauwaert Friederike Mey Michiel Stock Jo Maertens Willem Waegeman Marjan De Mey Predictive design of sigma factor-specific promoters |
description |
Automated design tools and tailored subunits are beneficial in fine-tuning all components of a complex genetic circuit. Here the authors create E. coli and B. subtilis promoter libraries using FACS and HTS, from which an online promoter design tool has been developed using CNN. |
format |
article |
author |
Maarten Van Brempt Jim Clauwaert Friederike Mey Michiel Stock Jo Maertens Willem Waegeman Marjan De Mey |
author_facet |
Maarten Van Brempt Jim Clauwaert Friederike Mey Michiel Stock Jo Maertens Willem Waegeman Marjan De Mey |
author_sort |
Maarten Van Brempt |
title |
Predictive design of sigma factor-specific promoters |
title_short |
Predictive design of sigma factor-specific promoters |
title_full |
Predictive design of sigma factor-specific promoters |
title_fullStr |
Predictive design of sigma factor-specific promoters |
title_full_unstemmed |
Predictive design of sigma factor-specific promoters |
title_sort |
predictive design of sigma factor-specific promoters |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/ae04ea037b8d404a8d08ac51c6a9e3ae |
work_keys_str_mv |
AT maartenvanbrempt predictivedesignofsigmafactorspecificpromoters AT jimclauwaert predictivedesignofsigmafactorspecificpromoters AT friederikemey predictivedesignofsigmafactorspecificpromoters AT michielstock predictivedesignofsigmafactorspecificpromoters AT jomaertens predictivedesignofsigmafactorspecificpromoters AT willemwaegeman predictivedesignofsigmafactorspecificpromoters AT marjandemey predictivedesignofsigmafactorspecificpromoters |
_version_ |
1718380141689700352 |