Predictive design of sigma factor-specific promoters

Automated design tools and tailored subunits are beneficial in fine-tuning all components of a complex genetic circuit. Here the authors create E. coli and B. subtilis promoter libraries using FACS and HTS, from which an online promoter design tool has been developed using CNN.

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Autores principales: Maarten Van Brempt, Jim Clauwaert, Friederike Mey, Michiel Stock, Jo Maertens, Willem Waegeman, Marjan De Mey
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/ae04ea037b8d404a8d08ac51c6a9e3ae
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spelling oai:doaj.org-article:ae04ea037b8d404a8d08ac51c6a9e3ae2021-12-02T17:32:58ZPredictive design of sigma factor-specific promoters10.1038/s41467-020-19446-w2041-1723https://doaj.org/article/ae04ea037b8d404a8d08ac51c6a9e3ae2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19446-whttps://doaj.org/toc/2041-1723Automated design tools and tailored subunits are beneficial in fine-tuning all components of a complex genetic circuit. Here the authors create E. coli and B. subtilis promoter libraries using FACS and HTS, from which an online promoter design tool has been developed using CNN.Maarten Van BremptJim ClauwaertFriederike MeyMichiel StockJo MaertensWillem WaegemanMarjan De MeyNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Maarten Van Brempt
Jim Clauwaert
Friederike Mey
Michiel Stock
Jo Maertens
Willem Waegeman
Marjan De Mey
Predictive design of sigma factor-specific promoters
description Automated design tools and tailored subunits are beneficial in fine-tuning all components of a complex genetic circuit. Here the authors create E. coli and B. subtilis promoter libraries using FACS and HTS, from which an online promoter design tool has been developed using CNN.
format article
author Maarten Van Brempt
Jim Clauwaert
Friederike Mey
Michiel Stock
Jo Maertens
Willem Waegeman
Marjan De Mey
author_facet Maarten Van Brempt
Jim Clauwaert
Friederike Mey
Michiel Stock
Jo Maertens
Willem Waegeman
Marjan De Mey
author_sort Maarten Van Brempt
title Predictive design of sigma factor-specific promoters
title_short Predictive design of sigma factor-specific promoters
title_full Predictive design of sigma factor-specific promoters
title_fullStr Predictive design of sigma factor-specific promoters
title_full_unstemmed Predictive design of sigma factor-specific promoters
title_sort predictive design of sigma factor-specific promoters
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/ae04ea037b8d404a8d08ac51c6a9e3ae
work_keys_str_mv AT maartenvanbrempt predictivedesignofsigmafactorspecificpromoters
AT jimclauwaert predictivedesignofsigmafactorspecificpromoters
AT friederikemey predictivedesignofsigmafactorspecificpromoters
AT michielstock predictivedesignofsigmafactorspecificpromoters
AT jomaertens predictivedesignofsigmafactorspecificpromoters
AT willemwaegeman predictivedesignofsigmafactorspecificpromoters
AT marjandemey predictivedesignofsigmafactorspecificpromoters
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