Oral Magnesium Supplementation for Treating Glucose Metabolism Parameters in People with or at Risk of Diabetes: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials

There is a large and growing body of literature focusing on the use of oral magnesium (Mg) supplementation for improving glucose metabolism in people with or at risk of diabetes. We therefore aimed to investigate the effect of oral Mg supplementation on glucose and insulin-sensitivity parameters in...

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Autores principales:	Nicola Veronese, Ligia J. Dominguez, Damiano Pizzol, Jacopo Demurtas, Lee Smith, Mario Barbagallo
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	magnesium diabetes glucose meta-analysis Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/ae04fdeb8eda4f519f12a32af32c945f
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spelling	oai:doaj.org-article:ae04fdeb8eda4f519f12a32af32c945f2021-11-25T18:36:34ZOral Magnesium Supplementation for Treating Glucose Metabolism Parameters in People with or at Risk of Diabetes: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials10.3390/nu131140742072-6643https://doaj.org/article/ae04fdeb8eda4f519f12a32af32c945f2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4074https://doaj.org/toc/2072-6643There is a large and growing body of literature focusing on the use of oral magnesium (Mg) supplementation for improving glucose metabolism in people with or at risk of diabetes. We therefore aimed to investigate the effect of oral Mg supplementation on glucose and insulin-sensitivity parameters in participants with diabetes or at high risk of diabetes, compared with a placebo. Several databases were searched investigating the effect of oral Mg supplementation vs placebo in patients with diabetes or conditions at high risk of diabetes. Data were reported as standardized mean differences (SMDs) with their 95% confidence intervals (CIs) using follow-up data of glucose and insulin-sensitivity parameters. Compared with placebo, Mg supplementation reduced fasting plasma glucose in people with diabetes. In people at high risk of diabetes, Mg supplementation significantly improved plasma glucose per se, and after a 2 h oral glucose tolerance test. Furthermore, Mg supplementation demonstrated an improvement in insulin sensitivity markers. In conclusion, Mg supplementation appears to have a beneficial role and improves glucose parameters in people with diabetes. Moreover, our work indicates that Mg supplementation may improve insulin-sensitivity parameters in those at high risk of diabetes.Nicola VeroneseLigia J. DominguezDamiano PizzolJacopo DemurtasLee SmithMario BarbagalloMDPI AGarticlemagnesiumdiabetesglucosemeta-analysisNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4074, p 4074 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	magnesium diabetes glucose meta-analysis Nutrition. Foods and food supply TX341-641
spellingShingle	magnesium diabetes glucose meta-analysis Nutrition. Foods and food supply TX341-641 Nicola Veronese Ligia J. Dominguez Damiano Pizzol Jacopo Demurtas Lee Smith Mario Barbagallo Oral Magnesium Supplementation for Treating Glucose Metabolism Parameters in People with or at Risk of Diabetes: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials
description	There is a large and growing body of literature focusing on the use of oral magnesium (Mg) supplementation for improving glucose metabolism in people with or at risk of diabetes. We therefore aimed to investigate the effect of oral Mg supplementation on glucose and insulin-sensitivity parameters in participants with diabetes or at high risk of diabetes, compared with a placebo. Several databases were searched investigating the effect of oral Mg supplementation vs placebo in patients with diabetes or conditions at high risk of diabetes. Data were reported as standardized mean differences (SMDs) with their 95% confidence intervals (CIs) using follow-up data of glucose and insulin-sensitivity parameters. Compared with placebo, Mg supplementation reduced fasting plasma glucose in people with diabetes. In people at high risk of diabetes, Mg supplementation significantly improved plasma glucose per se, and after a 2 h oral glucose tolerance test. Furthermore, Mg supplementation demonstrated an improvement in insulin sensitivity markers. In conclusion, Mg supplementation appears to have a beneficial role and improves glucose parameters in people with diabetes. Moreover, our work indicates that Mg supplementation may improve insulin-sensitivity parameters in those at high risk of diabetes.
format	article
author	Nicola Veronese Ligia J. Dominguez Damiano Pizzol Jacopo Demurtas Lee Smith Mario Barbagallo
author_facet	Nicola Veronese Ligia J. Dominguez Damiano Pizzol Jacopo Demurtas Lee Smith Mario Barbagallo
author_sort	Nicola Veronese
title	Oral Magnesium Supplementation for Treating Glucose Metabolism Parameters in People with or at Risk of Diabetes: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials
title_short	Oral Magnesium Supplementation for Treating Glucose Metabolism Parameters in People with or at Risk of Diabetes: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials
title_full	Oral Magnesium Supplementation for Treating Glucose Metabolism Parameters in People with or at Risk of Diabetes: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials
title_fullStr	Oral Magnesium Supplementation for Treating Glucose Metabolism Parameters in People with or at Risk of Diabetes: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials
title_full_unstemmed	Oral Magnesium Supplementation for Treating Glucose Metabolism Parameters in People with or at Risk of Diabetes: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials
title_sort	oral magnesium supplementation for treating glucose metabolism parameters in people with or at risk of diabetes: a systematic review and meta-analysis of double-blind randomized controlled trials
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ae04fdeb8eda4f519f12a32af32c945f
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Oral Magnesium Supplementation for Treating Glucose Metabolism Parameters in People with or at Risk of Diabetes: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials

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