The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD
Infants born to obese mothers have altered microbiome and increased risk of obesity and NAFLD. Here the authors establish causality by showing that maternal obesity-shaped infant gut microbiome induces macrophage dysfunction, inflammation, and diet-induced metabolic disease in germ-free mice.
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Nature Portfolio
2018
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oai:doaj.org-article:ae080f0844c14d709b3a8306cb9877f42021-12-02T14:39:23ZThe gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD10.1038/s41467-018-06929-02041-1723https://doaj.org/article/ae080f0844c14d709b3a8306cb9877f42018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06929-0https://doaj.org/toc/2041-1723Infants born to obese mothers have altered microbiome and increased risk of obesity and NAFLD. Here the authors establish causality by showing that maternal obesity-shaped infant gut microbiome induces macrophage dysfunction, inflammation, and diet-induced metabolic disease in germ-free mice.Taylor K. SoderborgSarah E. ClarkChristopher E. MulliganRachel C. JanssenLyndsey BabcockDiana IrBridget YoungNancy KrebsDominick J. LemasLinda K. JohnsonTiffany WeirLaurel L. LenzDaniel N. FrankTeri L. HernandezKristine A. KuhnAngelo D’AlessandroLinda A. BarbourKarim C. El KasmiJacob E. FriedmanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Taylor K. Soderborg Sarah E. Clark Christopher E. Mulligan Rachel C. Janssen Lyndsey Babcock Diana Ir Bridget Young Nancy Krebs Dominick J. Lemas Linda K. Johnson Tiffany Weir Laurel L. Lenz Daniel N. Frank Teri L. Hernandez Kristine A. Kuhn Angelo D’Alessandro Linda A. Barbour Karim C. El Kasmi Jacob E. Friedman The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD |
| description |
Infants born to obese mothers have altered microbiome and increased risk of obesity and NAFLD. Here the authors establish causality by showing that maternal obesity-shaped infant gut microbiome induces macrophage dysfunction, inflammation, and diet-induced metabolic disease in germ-free mice. |
| format |
article |
| author |
Taylor K. Soderborg Sarah E. Clark Christopher E. Mulligan Rachel C. Janssen Lyndsey Babcock Diana Ir Bridget Young Nancy Krebs Dominick J. Lemas Linda K. Johnson Tiffany Weir Laurel L. Lenz Daniel N. Frank Teri L. Hernandez Kristine A. Kuhn Angelo D’Alessandro Linda A. Barbour Karim C. El Kasmi Jacob E. Friedman |
| author_facet |
Taylor K. Soderborg Sarah E. Clark Christopher E. Mulligan Rachel C. Janssen Lyndsey Babcock Diana Ir Bridget Young Nancy Krebs Dominick J. Lemas Linda K. Johnson Tiffany Weir Laurel L. Lenz Daniel N. Frank Teri L. Hernandez Kristine A. Kuhn Angelo D’Alessandro Linda A. Barbour Karim C. El Kasmi Jacob E. Friedman |
| author_sort |
Taylor K. Soderborg |
| title |
The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD |
| title_short |
The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD |
| title_full |
The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD |
| title_fullStr |
The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD |
| title_full_unstemmed |
The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD |
| title_sort |
gut microbiota in infants of obese mothers increases inflammation and susceptibility to nafld |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/ae080f0844c14d709b3a8306cb9877f4 |
| work_keys_str_mv |
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