Differential expression of serum biomarkers in hemodialysis patients with mild cognitive decline: A prospective single-center cohort study

Abstract Studies suggest that hemodialysis patients are at a higher risk for cognitive decline than healthy individuals; however, underlying mechanisms have not been fully elucidated. We aimed to investigate the roles of serum biomarkers, such as brain-derived neurotrophic factor (BDNF), inflammator...

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Autores principales:	Bin Zhu, Li-Na Jin, Jian-Qin Shen, Jin-Feng Liu, Ri-Yue Jiang, Ling Yang, Jie Zhang, Ai-Lin Luo, Li-Ying Miao, Chun Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ae09e3b3d7474ed9bbafabea5d5a72b9
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spelling	oai:doaj.org-article:ae09e3b3d7474ed9bbafabea5d5a72b92021-12-02T15:08:22ZDifferential expression of serum biomarkers in hemodialysis patients with mild cognitive decline: A prospective single-center cohort study10.1038/s41598-018-29760-52045-2322https://doaj.org/article/ae09e3b3d7474ed9bbafabea5d5a72b92018-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-29760-5https://doaj.org/toc/2045-2322Abstract Studies suggest that hemodialysis patients are at a higher risk for cognitive decline than healthy individuals; however, underlying mechanisms have not been fully elucidated. We aimed to investigate the roles of serum biomarkers, such as brain-derived neurotrophic factor (BDNF), inflammatory cytokines, fibroblast growth factor (FGF)-23 and its co-receptor α-klotho and platelet (PLT) count in mild cognitive decline (MCD) of patients undergoing hemodialysis in this prospective cohort study. Serum levels of BDNF, tumour necrosis factor (TNF)-α, interleukin (IL)-6 and the number of PLT were significantly altered in the MCD group compared with those in healthy controls (HCs) or those with normal cognitive function (NCF). Although serum α-klotho and FGF-23 levels were significantly altered in the MCD group, there were no statistical differences between the MCD and NCF groups. Serum BDNF levels and PLT counts were significantly correlated with cognitive test scores. Receiver operating characteristic (ROC) curves demonstrated that BDNF and PLT were potential biomarkers for improved MCD diagnosis in patients with hemodialysis. These findings suggest that hemodialysis-related MCD is associated with altered BDNF, TNF-α and IL-6 levels as well as PLT counts and that serum BDNF levels and PLT counts are potential biomarkers for hemodialysis-related MCD diagnosis.Bin ZhuLi-Na JinJian-Qin ShenJin-Feng LiuRi-Yue JiangLing YangJie ZhangAi-Lin LuoLi-Ying MiaoChun YangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bin Zhu Li-Na Jin Jian-Qin Shen Jin-Feng Liu Ri-Yue Jiang Ling Yang Jie Zhang Ai-Lin Luo Li-Ying Miao Chun Yang Differential expression of serum biomarkers in hemodialysis patients with mild cognitive decline: A prospective single-center cohort study
description	Abstract Studies suggest that hemodialysis patients are at a higher risk for cognitive decline than healthy individuals; however, underlying mechanisms have not been fully elucidated. We aimed to investigate the roles of serum biomarkers, such as brain-derived neurotrophic factor (BDNF), inflammatory cytokines, fibroblast growth factor (FGF)-23 and its co-receptor α-klotho and platelet (PLT) count in mild cognitive decline (MCD) of patients undergoing hemodialysis in this prospective cohort study. Serum levels of BDNF, tumour necrosis factor (TNF)-α, interleukin (IL)-6 and the number of PLT were significantly altered in the MCD group compared with those in healthy controls (HCs) or those with normal cognitive function (NCF). Although serum α-klotho and FGF-23 levels were significantly altered in the MCD group, there were no statistical differences between the MCD and NCF groups. Serum BDNF levels and PLT counts were significantly correlated with cognitive test scores. Receiver operating characteristic (ROC) curves demonstrated that BDNF and PLT were potential biomarkers for improved MCD diagnosis in patients with hemodialysis. These findings suggest that hemodialysis-related MCD is associated with altered BDNF, TNF-α and IL-6 levels as well as PLT counts and that serum BDNF levels and PLT counts are potential biomarkers for hemodialysis-related MCD diagnosis.
format	article
author	Bin Zhu Li-Na Jin Jian-Qin Shen Jin-Feng Liu Ri-Yue Jiang Ling Yang Jie Zhang Ai-Lin Luo Li-Ying Miao Chun Yang
author_facet	Bin Zhu Li-Na Jin Jian-Qin Shen Jin-Feng Liu Ri-Yue Jiang Ling Yang Jie Zhang Ai-Lin Luo Li-Ying Miao Chun Yang
author_sort	Bin Zhu
title	Differential expression of serum biomarkers in hemodialysis patients with mild cognitive decline: A prospective single-center cohort study
title_short	Differential expression of serum biomarkers in hemodialysis patients with mild cognitive decline: A prospective single-center cohort study
title_full	Differential expression of serum biomarkers in hemodialysis patients with mild cognitive decline: A prospective single-center cohort study
title_fullStr	Differential expression of serum biomarkers in hemodialysis patients with mild cognitive decline: A prospective single-center cohort study
title_full_unstemmed	Differential expression of serum biomarkers in hemodialysis patients with mild cognitive decline: A prospective single-center cohort study
title_sort	differential expression of serum biomarkers in hemodialysis patients with mild cognitive decline: a prospective single-center cohort study
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ae09e3b3d7474ed9bbafabea5d5a72b9
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Differential expression of serum biomarkers in hemodialysis patients with mild cognitive decline: A prospective single-center cohort study

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