Genome-wide screening identifies a KCNIP1 copy number variant as a genetic predictor for atrial fibrillation

Genome-wide screening identifies a KCNIP1 copy number variant as a genetic predictor for atrial fibrillation

Tsai et al. here utilize a multi-stage genome-wide association study in Taiwanese population to show a copy number variation in the intron of potassium interacting channel 1 gene (KCNIP1) to be strongly associated with atrial fibrillation. The study also examines the functionality of KCNIP1 in heart...

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Main Authors: Chia-Ti Tsai, Chia-Shan Hsieh, Sheng-Nan Chang, Eric Y. Chuang, Kwo-Chang Ueng, Chin-Feng Tsai, Tsung-Hsien Lin, Cho-Kai Wu, Jen-Kuang Lee, Lian-Yu Lin, Yi-Chih Wang, Chih-Chieh Yu, Ling-Ping Lai, Chuen-Den Tseng, Juey-Jen Hwang, Fu-Tien Chiang, Jiunn-Lee Lin
Format: article
Language:EN
Published: Nature Portfolio 2016
Subjects:
Science
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Online Access:https://doaj.org/article/ae0b2f3bbf4f455ea88fd5d422ffefc4
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Summary:Tsai et al. here utilize a multi-stage genome-wide association study in Taiwanese population to show a copy number variation in the intron of potassium interacting channel 1 gene (KCNIP1) to be strongly associated with atrial fibrillation. The study also examines the functionality of KCNIP1 in heart electrophysiological function using cultured myocytes and zebrafish.

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