Genome-wide screening identifies a KCNIP1 copy number variant as a genetic predictor for atrial fibrillation

Tsai et al. here utilize a multi-stage genome-wide association study in Taiwanese population to show a copy number variation in the intron of potassium interacting channel 1 gene (KCNIP1) to be strongly associated with atrial fibrillation. The study also examines the functionality of KCNIP1 in heart...

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Autores principales:	Chia-Ti Tsai, Chia-Shan Hsieh, Sheng-Nan Chang, Eric Y. Chuang, Kwo-Chang Ueng, Chin-Feng Tsai, Tsung-Hsien Lin, Cho-Kai Wu, Jen-Kuang Lee, Lian-Yu Lin, Yi-Chih Wang, Chih-Chieh Yu, Ling-Ping Lai, Chuen-Den Tseng, Juey-Jen Hwang, Fu-Tien Chiang, Jiunn-Lee Lin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ae0b2f3bbf4f455ea88fd5d422ffefc4
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spelling	oai:doaj.org-article:ae0b2f3bbf4f455ea88fd5d422ffefc42021-12-02T15:34:52ZGenome-wide screening identifies a KCNIP1 copy number variant as a genetic predictor for atrial fibrillation10.1038/ncomms101902041-1723https://doaj.org/article/ae0b2f3bbf4f455ea88fd5d422ffefc42016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10190https://doaj.org/toc/2041-1723Tsai et al. here utilize a multi-stage genome-wide association study in Taiwanese population to show a copy number variation in the intron of potassium interacting channel 1 gene (KCNIP1) to be strongly associated with atrial fibrillation. The study also examines the functionality of KCNIP1 in heart electrophysiological function using cultured myocytes and zebrafish.Chia-Ti TsaiChia-Shan HsiehSheng-Nan ChangEric Y. ChuangKwo-Chang UengChin-Feng TsaiTsung-Hsien LinCho-Kai WuJen-Kuang LeeLian-Yu LinYi-Chih WangChih-Chieh YuLing-Ping LaiChuen-Den TsengJuey-Jen HwangFu-Tien ChiangJiunn-Lee LinNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chia-Ti Tsai Chia-Shan Hsieh Sheng-Nan Chang Eric Y. Chuang Kwo-Chang Ueng Chin-Feng Tsai Tsung-Hsien Lin Cho-Kai Wu Jen-Kuang Lee Lian-Yu Lin Yi-Chih Wang Chih-Chieh Yu Ling-Ping Lai Chuen-Den Tseng Juey-Jen Hwang Fu-Tien Chiang Jiunn-Lee Lin Genome-wide screening identifies a KCNIP1 copy number variant as a genetic predictor for atrial fibrillation
description	Tsai et al. here utilize a multi-stage genome-wide association study in Taiwanese population to show a copy number variation in the intron of potassium interacting channel 1 gene (KCNIP1) to be strongly associated with atrial fibrillation. The study also examines the functionality of KCNIP1 in heart electrophysiological function using cultured myocytes and zebrafish.
format	article
author	Chia-Ti Tsai Chia-Shan Hsieh Sheng-Nan Chang Eric Y. Chuang Kwo-Chang Ueng Chin-Feng Tsai Tsung-Hsien Lin Cho-Kai Wu Jen-Kuang Lee Lian-Yu Lin Yi-Chih Wang Chih-Chieh Yu Ling-Ping Lai Chuen-Den Tseng Juey-Jen Hwang Fu-Tien Chiang Jiunn-Lee Lin
author_facet	Chia-Ti Tsai Chia-Shan Hsieh Sheng-Nan Chang Eric Y. Chuang Kwo-Chang Ueng Chin-Feng Tsai Tsung-Hsien Lin Cho-Kai Wu Jen-Kuang Lee Lian-Yu Lin Yi-Chih Wang Chih-Chieh Yu Ling-Ping Lai Chuen-Den Tseng Juey-Jen Hwang Fu-Tien Chiang Jiunn-Lee Lin
author_sort	Chia-Ti Tsai
title	Genome-wide screening identifies a KCNIP1 copy number variant as a genetic predictor for atrial fibrillation
title_short	Genome-wide screening identifies a KCNIP1 copy number variant as a genetic predictor for atrial fibrillation
title_full	Genome-wide screening identifies a KCNIP1 copy number variant as a genetic predictor for atrial fibrillation
title_fullStr	Genome-wide screening identifies a KCNIP1 copy number variant as a genetic predictor for atrial fibrillation
title_full_unstemmed	Genome-wide screening identifies a KCNIP1 copy number variant as a genetic predictor for atrial fibrillation
title_sort	genome-wide screening identifies a kcnip1 copy number variant as a genetic predictor for atrial fibrillation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/ae0b2f3bbf4f455ea88fd5d422ffefc4
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Genome-wide screening identifies a KCNIP1 copy number variant as a genetic predictor for atrial fibrillation

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