Evaluating the effects of crystallinity in new biocompatible polyester nanocarriers on drug release behavior

Vassilios Karavelidis1,2, Evangelos Karavas2, Dimitrios Giliopoulos1, Sofia Papadimitriou1, Dimitrios Bikiaris11Laboratory of Polymer Chemistry and Technology, Chemistry Department, Aristotle University of Thessaloniki, Thessaloniki, 2Pharmathen SA, Pharmaceutical Industry, Pallini Attikis, Attiki,...

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Autores principales:	Karavelidis V, Karavas E, Giliopoulos D, Papadimitriou S, Bikiaris D
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ae0dfc55c9f246b1b0f574154b1e6ae6
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spelling	oai:doaj.org-article:ae0dfc55c9f246b1b0f574154b1e6ae62021-12-02T05:17:41ZEvaluating the effects of crystallinity in new biocompatible polyester nanocarriers on drug release behavior1176-91141178-2013https://doaj.org/article/ae0dfc55c9f246b1b0f574154b1e6ae62011-11-01T00:00:00Zhttp://www.dovepress.com/evaluating-the-effects-of-crystallinity-in-new-biocompatible-polyester-a8731https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Vassilios Karavelidis1,2, Evangelos Karavas2, Dimitrios Giliopoulos1, Sofia Papadimitriou1, Dimitrios Bikiaris11Laboratory of Polymer Chemistry and Technology, Chemistry Department, Aristotle University of Thessaloniki, Thessaloniki, 2Pharmathen SA, Pharmaceutical Industry, Pallini Attikis, Attiki, GreeceAbstract: Four new polyesters based on 1,3-propanediol and different aliphatic dicarboxylic acids were used to prepare ropinirole HCl-loaded nanoparticles. The novelty of this study lies in the use of polyesters with similar melting points but different degrees of crystallinity, varying from 29.8% to 67.5%, as drug nanocarriers. Based on their toxicity to human umbilical vein endothelial cells, these aliphatic polyesters were found to have cytotoxicity similar to that of polylactic acid and so may be considered as prominent drug nanocarriers. Drug encapsulation in polyesters was performed via an emulsification/solvent evaporation method. The mean particle size of drug-loaded nanoparticles was 164&ndash;228 nm, and the drug loading content was 16%&ndash;23%. Wide angle X-ray diffraction patterns showed that ropinirole HCl existed in an amorphous state within the nanoparticle polymer matrices. Drug release diagrams revealed a burst effect for ropinirole HCl in the first 6 hours, probably due to release of drug located on the nanoparticle surface, followed by slower release. The degree of crystallinity of the host polymer matrix seemed to be an important parameter, because higher drug release rates were observed in polyesters with a low degree of crystallinity.Keywords: biocompatible polyesters, nanoparticles, ropinirole, release, crystallinityKaravelidis VKaravas EGiliopoulos DPapadimitriou SBikiaris DDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 3021-3032 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Karavelidis V Karavas E Giliopoulos D Papadimitriou S Bikiaris D Evaluating the effects of crystallinity in new biocompatible polyester nanocarriers on drug release behavior
description	Vassilios Karavelidis1,2, Evangelos Karavas2, Dimitrios Giliopoulos1, Sofia Papadimitriou1, Dimitrios Bikiaris11Laboratory of Polymer Chemistry and Technology, Chemistry Department, Aristotle University of Thessaloniki, Thessaloniki, 2Pharmathen SA, Pharmaceutical Industry, Pallini Attikis, Attiki, GreeceAbstract: Four new polyesters based on 1,3-propanediol and different aliphatic dicarboxylic acids were used to prepare ropinirole HCl-loaded nanoparticles. The novelty of this study lies in the use of polyesters with similar melting points but different degrees of crystallinity, varying from 29.8% to 67.5%, as drug nanocarriers. Based on their toxicity to human umbilical vein endothelial cells, these aliphatic polyesters were found to have cytotoxicity similar to that of polylactic acid and so may be considered as prominent drug nanocarriers. Drug encapsulation in polyesters was performed via an emulsification/solvent evaporation method. The mean particle size of drug-loaded nanoparticles was 164&ndash;228 nm, and the drug loading content was 16%&ndash;23%. Wide angle X-ray diffraction patterns showed that ropinirole HCl existed in an amorphous state within the nanoparticle polymer matrices. Drug release diagrams revealed a burst effect for ropinirole HCl in the first 6 hours, probably due to release of drug located on the nanoparticle surface, followed by slower release. The degree of crystallinity of the host polymer matrix seemed to be an important parameter, because higher drug release rates were observed in polyesters with a low degree of crystallinity.Keywords: biocompatible polyesters, nanoparticles, ropinirole, release, crystallinity
format	article
author	Karavelidis V Karavas E Giliopoulos D Papadimitriou S Bikiaris D
author_facet	Karavelidis V Karavas E Giliopoulos D Papadimitriou S Bikiaris D
author_sort	Karavelidis V
title	Evaluating the effects of crystallinity in new biocompatible polyester nanocarriers on drug release behavior
title_short	Evaluating the effects of crystallinity in new biocompatible polyester nanocarriers on drug release behavior
title_full	Evaluating the effects of crystallinity in new biocompatible polyester nanocarriers on drug release behavior
title_fullStr	Evaluating the effects of crystallinity in new biocompatible polyester nanocarriers on drug release behavior
title_full_unstemmed	Evaluating the effects of crystallinity in new biocompatible polyester nanocarriers on drug release behavior
title_sort	evaluating the effects of crystallinity in new biocompatible polyester nanocarriers on drug release behavior
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/ae0dfc55c9f246b1b0f574154b1e6ae6
work_keys_str_mv	AT karavelidisv evaluatingtheeffectsofcrystallinityinnewbiocompatiblepolyesternanocarriersondrugreleasebehavior AT karavase evaluatingtheeffectsofcrystallinityinnewbiocompatiblepolyesternanocarriersondrugreleasebehavior AT giliopoulosd evaluatingtheeffectsofcrystallinityinnewbiocompatiblepolyesternanocarriersondrugreleasebehavior AT papadimitrious evaluatingtheeffectsofcrystallinityinnewbiocompatiblepolyesternanocarriersondrugreleasebehavior AT bikiarisd evaluatingtheeffectsofcrystallinityinnewbiocompatiblepolyesternanocarriersondrugreleasebehavior
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Evaluating the effects of crystallinity in new biocompatible polyester nanocarriers on drug release behavior

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