Acupuncture With deqi Modulates the Hemodynamic Response and Functional Connectivity of the Prefrontal-Motor Cortical Network

As a world intangible cultural heritage, acupuncture is considered an essential modality of complementary and alternative therapy to Western medicine. Despite acupuncture’s long history and public acceptance, how the cortical network is modulated by acupuncture remains largely unclear. Moreover, as...

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Autores principales:	Xiaopeng Si, Shaoxin Xiang, Ludan Zhang, Sicheng Li, Kuo Zhang, Dong Ming
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	acupuncture functional connectivity functional near-infrared spectroscopy motor cortex prefrontal cortex Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/ae0e0e07af994fdc9aab7786cf2fbadc
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spelling	oai:doaj.org-article:ae0e0e07af994fdc9aab7786cf2fbadc2021-11-10T14:52:48ZAcupuncture With deqi Modulates the Hemodynamic Response and Functional Connectivity of the Prefrontal-Motor Cortical Network1662-453X10.3389/fnins.2021.693623https://doaj.org/article/ae0e0e07af994fdc9aab7786cf2fbadc2021-08-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnins.2021.693623/fullhttps://doaj.org/toc/1662-453XAs a world intangible cultural heritage, acupuncture is considered an essential modality of complementary and alternative therapy to Western medicine. Despite acupuncture’s long history and public acceptance, how the cortical network is modulated by acupuncture remains largely unclear. Moreover, as the basic acupuncture unit for regulating the central nervous system, how the cortical network is modulated during acupuncture at the Hegu acupoint is mostly unclear. Here, multi-channel functional near-infrared spectroscopy (fNIRS) data were recorded from twenty healthy subjects for acupuncture manipulation, pre- and post-manipulation tactile controls, and pre- and post-acupuncture rest controls. Results showed that: (1) acupuncture manipulation caused significantly increased acupuncture behavioral deqi performance compared with tactile controls. (2) The bilateral prefrontal cortex (PFC) and motor cortex were significantly inhibited during acupuncture manipulation than controls, which was evidenced by the decreased power of oxygenated hemoglobin (HbO) concentration. (3) The bilateral PFC’s hemodynamic responses showed a positive correlation trend with acupuncture behavioral performance. (4) The network connections with bilateral PFC as nodes showed significantly increased functional connectivity during acupuncture manipulation compared with controls. (5) Meanwhile, the network’s efficiency was improved by acupuncture manipulation, evidenced by the increased global efficiency and decreased shortest path length. Taken together, these results reveal that a cooperative PFC-Motor functional network could be modulated by acupuncture manipulation at the Hegu acupoint. This study provides neuroimaging evidence that explains acupuncture’s neuromodulation effects on the cortical network.Xiaopeng SiXiaopeng SiXiaopeng SiXiaopeng SiShaoxin XiangShaoxin XiangLudan ZhangLudan ZhangSicheng LiSicheng LiKuo ZhangKuo ZhangDong MingDong MingFrontiers Media S.A.articleacupuncturefunctional connectivityfunctional near-infrared spectroscopymotor cortexprefrontal cortexNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	acupuncture functional connectivity functional near-infrared spectroscopy motor cortex prefrontal cortex Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	acupuncture functional connectivity functional near-infrared spectroscopy motor cortex prefrontal cortex Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Xiaopeng Si Xiaopeng Si Xiaopeng Si Xiaopeng Si Shaoxin Xiang Shaoxin Xiang Ludan Zhang Ludan Zhang Sicheng Li Sicheng Li Kuo Zhang Kuo Zhang Dong Ming Dong Ming Acupuncture With deqi Modulates the Hemodynamic Response and Functional Connectivity of the Prefrontal-Motor Cortical Network
description	As a world intangible cultural heritage, acupuncture is considered an essential modality of complementary and alternative therapy to Western medicine. Despite acupuncture’s long history and public acceptance, how the cortical network is modulated by acupuncture remains largely unclear. Moreover, as the basic acupuncture unit for regulating the central nervous system, how the cortical network is modulated during acupuncture at the Hegu acupoint is mostly unclear. Here, multi-channel functional near-infrared spectroscopy (fNIRS) data were recorded from twenty healthy subjects for acupuncture manipulation, pre- and post-manipulation tactile controls, and pre- and post-acupuncture rest controls. Results showed that: (1) acupuncture manipulation caused significantly increased acupuncture behavioral deqi performance compared with tactile controls. (2) The bilateral prefrontal cortex (PFC) and motor cortex were significantly inhibited during acupuncture manipulation than controls, which was evidenced by the decreased power of oxygenated hemoglobin (HbO) concentration. (3) The bilateral PFC’s hemodynamic responses showed a positive correlation trend with acupuncture behavioral performance. (4) The network connections with bilateral PFC as nodes showed significantly increased functional connectivity during acupuncture manipulation compared with controls. (5) Meanwhile, the network’s efficiency was improved by acupuncture manipulation, evidenced by the increased global efficiency and decreased shortest path length. Taken together, these results reveal that a cooperative PFC-Motor functional network could be modulated by acupuncture manipulation at the Hegu acupoint. This study provides neuroimaging evidence that explains acupuncture’s neuromodulation effects on the cortical network.
format	article
author	Xiaopeng Si Xiaopeng Si Xiaopeng Si Xiaopeng Si Shaoxin Xiang Shaoxin Xiang Ludan Zhang Ludan Zhang Sicheng Li Sicheng Li Kuo Zhang Kuo Zhang Dong Ming Dong Ming
author_facet	Xiaopeng Si Xiaopeng Si Xiaopeng Si Xiaopeng Si Shaoxin Xiang Shaoxin Xiang Ludan Zhang Ludan Zhang Sicheng Li Sicheng Li Kuo Zhang Kuo Zhang Dong Ming Dong Ming
author_sort	Xiaopeng Si
title	Acupuncture With deqi Modulates the Hemodynamic Response and Functional Connectivity of the Prefrontal-Motor Cortical Network
title_short	Acupuncture With deqi Modulates the Hemodynamic Response and Functional Connectivity of the Prefrontal-Motor Cortical Network
title_full	Acupuncture With deqi Modulates the Hemodynamic Response and Functional Connectivity of the Prefrontal-Motor Cortical Network
title_fullStr	Acupuncture With deqi Modulates the Hemodynamic Response and Functional Connectivity of the Prefrontal-Motor Cortical Network
title_full_unstemmed	Acupuncture With deqi Modulates the Hemodynamic Response and Functional Connectivity of the Prefrontal-Motor Cortical Network
title_sort	acupuncture with deqi modulates the hemodynamic response and functional connectivity of the prefrontal-motor cortical network
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/ae0e0e07af994fdc9aab7786cf2fbadc
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Acupuncture With deqi Modulates the Hemodynamic Response and Functional Connectivity of the Prefrontal-Motor Cortical Network

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