The Firre locus produces a trans-acting RNA molecule that functions in hematopoiesis

LncRNA loci potentially contain multiple modes that can exert function, including DNA regulatory elements. Here, the authors generated genetic models in mice to dissect the role of the syntenically conserved lncRNA Firre in the context of hematopoiesis.

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Autores principales:	Jordan P. Lewandowski, James C. Lee, Taeyoung Hwang, Hongjae Sunwoo, Jill M. Goldstein, Abigail F. Groff, Nydia P. Chang, William Mallard, Adam Williams, Jorge Henao-Meija, Richard A. Flavell, Jeannie T. Lee, Chiara Gerhardinger, Amy J. Wagers, John L. Rinn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ae0f94d7e6434786ac485113730f81c4
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spelling	oai:doaj.org-article:ae0f94d7e6434786ac485113730f81c42021-12-02T14:38:59ZThe Firre locus produces a trans-acting RNA molecule that functions in hematopoiesis10.1038/s41467-019-12970-42041-1723https://doaj.org/article/ae0f94d7e6434786ac485113730f81c42019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12970-4https://doaj.org/toc/2041-1723LncRNA loci potentially contain multiple modes that can exert function, including DNA regulatory elements. Here, the authors generated genetic models in mice to dissect the role of the syntenically conserved lncRNA Firre in the context of hematopoiesis.Jordan P. LewandowskiJames C. LeeTaeyoung HwangHongjae SunwooJill M. GoldsteinAbigail F. GroffNydia P. ChangWilliam MallardAdam WilliamsJorge Henao-MeijaRichard A. FlavellJeannie T. LeeChiara GerhardingerAmy J. WagersJohn L. RinnNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jordan P. Lewandowski James C. Lee Taeyoung Hwang Hongjae Sunwoo Jill M. Goldstein Abigail F. Groff Nydia P. Chang William Mallard Adam Williams Jorge Henao-Meija Richard A. Flavell Jeannie T. Lee Chiara Gerhardinger Amy J. Wagers John L. Rinn The Firre locus produces a trans-acting RNA molecule that functions in hematopoiesis
description	LncRNA loci potentially contain multiple modes that can exert function, including DNA regulatory elements. Here, the authors generated genetic models in mice to dissect the role of the syntenically conserved lncRNA Firre in the context of hematopoiesis.
format	article
author	Jordan P. Lewandowski James C. Lee Taeyoung Hwang Hongjae Sunwoo Jill M. Goldstein Abigail F. Groff Nydia P. Chang William Mallard Adam Williams Jorge Henao-Meija Richard A. Flavell Jeannie T. Lee Chiara Gerhardinger Amy J. Wagers John L. Rinn
author_facet	Jordan P. Lewandowski James C. Lee Taeyoung Hwang Hongjae Sunwoo Jill M. Goldstein Abigail F. Groff Nydia P. Chang William Mallard Adam Williams Jorge Henao-Meija Richard A. Flavell Jeannie T. Lee Chiara Gerhardinger Amy J. Wagers John L. Rinn
author_sort	Jordan P. Lewandowski
title	The Firre locus produces a trans-acting RNA molecule that functions in hematopoiesis
title_short	The Firre locus produces a trans-acting RNA molecule that functions in hematopoiesis
title_full	The Firre locus produces a trans-acting RNA molecule that functions in hematopoiesis
title_fullStr	The Firre locus produces a trans-acting RNA molecule that functions in hematopoiesis
title_full_unstemmed	The Firre locus produces a trans-acting RNA molecule that functions in hematopoiesis
title_sort	firre locus produces a trans-acting rna molecule that functions in hematopoiesis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ae0f94d7e6434786ac485113730f81c4
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The Firre locus produces a trans-acting RNA molecule that functions in hematopoiesis

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