Novel multi-strain probiotics reduces Pasteurella multocida induced fowl cholera mortality in broilers

Abstract Pasteurella multocida causes fowl cholera, a highly contagious poultry disease of global concern, causing significant ecological and economic challenges to the poultry industry each year. This study evaluated the effects of novel multi-strain probiotics consisting of Lactobacillus plantarum...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Rine Christopher Reuben, Shovon Lal Sarkar, Habiba Ibnat, Md. Ali Ahasan Setu, Pravas Chandra Roy, Iqbal Kabir Jahid
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ae0fb447b2764f48887962734494165c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ae0fb447b2764f48887962734494165c
record_format	dspace
spelling	oai:doaj.org-article:ae0fb447b2764f48887962734494165c2021-12-02T13:40:51ZNovel multi-strain probiotics reduces Pasteurella multocida induced fowl cholera mortality in broilers10.1038/s41598-021-88299-02045-2322https://doaj.org/article/ae0fb447b2764f48887962734494165c2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88299-0https://doaj.org/toc/2045-2322Abstract Pasteurella multocida causes fowl cholera, a highly contagious poultry disease of global concern, causing significant ecological and economic challenges to the poultry industry each year. This study evaluated the effects of novel multi-strain probiotics consisting of Lactobacillus plantarum, L. fermentum, Pediococcus acidilactici, Enterococcus faecium and Saccharomyces cerevisiae on growth performance, intestinal microbiota, haemato-biochemical parameters and anti-inflammatory properties on broilers experimentally challenged with P. multocida. A total of 120 birds were fed with a basal diet supplemented with probiotics (108 CFU/kg) and then orally challenged with 108 CFU/mL of P. multocida. Probiotics supplementation significantly (P < 0.05) improved growth performance and feed efficiency as well as reducing (P < 0.05) the population of intestinal P. multocida, enterobacteria, and mortality. Haemato-biochemical parameters including total cholesterol, white blood cells (WBC), proteins, glucose, packed cell volume (PCV) and lymphocytes improved (P < 0.05) among probiotic fed birds when compared with the controls. Transcriptional profiles of anti-inflammatory genes including hypoxia inducible factor 1 alpha (HIF1A), tumor necrosis factor- (TNF) stimulated gene-6 (TSG-6) and prostaglandin E receptor 2 (PTGER2) in the intestinal mucosa were upregulated (P < 0.05) in probiotics fed birds. The dietary inclusion of the novel multi-strain probiotics improves growth performance, feed efficiency and intestinal health while attenuating inflammatory reaction, clinical signs and mortality associated with P. multocida infection in broilers.Rine Christopher ReubenShovon Lal SarkarHabiba IbnatMd. Ali Ahasan SetuPravas Chandra RoyIqbal Kabir JahidNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rine Christopher Reuben Shovon Lal Sarkar Habiba Ibnat Md. Ali Ahasan Setu Pravas Chandra Roy Iqbal Kabir Jahid Novel multi-strain probiotics reduces Pasteurella multocida induced fowl cholera mortality in broilers
description	Abstract Pasteurella multocida causes fowl cholera, a highly contagious poultry disease of global concern, causing significant ecological and economic challenges to the poultry industry each year. This study evaluated the effects of novel multi-strain probiotics consisting of Lactobacillus plantarum, L. fermentum, Pediococcus acidilactici, Enterococcus faecium and Saccharomyces cerevisiae on growth performance, intestinal microbiota, haemato-biochemical parameters and anti-inflammatory properties on broilers experimentally challenged with P. multocida. A total of 120 birds were fed with a basal diet supplemented with probiotics (108 CFU/kg) and then orally challenged with 108 CFU/mL of P. multocida. Probiotics supplementation significantly (P < 0.05) improved growth performance and feed efficiency as well as reducing (P < 0.05) the population of intestinal P. multocida, enterobacteria, and mortality. Haemato-biochemical parameters including total cholesterol, white blood cells (WBC), proteins, glucose, packed cell volume (PCV) and lymphocytes improved (P < 0.05) among probiotic fed birds when compared with the controls. Transcriptional profiles of anti-inflammatory genes including hypoxia inducible factor 1 alpha (HIF1A), tumor necrosis factor- (TNF) stimulated gene-6 (TSG-6) and prostaglandin E receptor 2 (PTGER2) in the intestinal mucosa were upregulated (P < 0.05) in probiotics fed birds. The dietary inclusion of the novel multi-strain probiotics improves growth performance, feed efficiency and intestinal health while attenuating inflammatory reaction, clinical signs and mortality associated with P. multocida infection in broilers.
format	article
author	Rine Christopher Reuben Shovon Lal Sarkar Habiba Ibnat Md. Ali Ahasan Setu Pravas Chandra Roy Iqbal Kabir Jahid
author_facet	Rine Christopher Reuben Shovon Lal Sarkar Habiba Ibnat Md. Ali Ahasan Setu Pravas Chandra Roy Iqbal Kabir Jahid
author_sort	Rine Christopher Reuben
title	Novel multi-strain probiotics reduces Pasteurella multocida induced fowl cholera mortality in broilers
title_short	Novel multi-strain probiotics reduces Pasteurella multocida induced fowl cholera mortality in broilers
title_full	Novel multi-strain probiotics reduces Pasteurella multocida induced fowl cholera mortality in broilers
title_fullStr	Novel multi-strain probiotics reduces Pasteurella multocida induced fowl cholera mortality in broilers
title_full_unstemmed	Novel multi-strain probiotics reduces Pasteurella multocida induced fowl cholera mortality in broilers
title_sort	novel multi-strain probiotics reduces pasteurella multocida induced fowl cholera mortality in broilers
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ae0fb447b2764f48887962734494165c
work_keys_str_mv	AT rinechristopherreuben novelmultistrainprobioticsreducespasteurellamultocidainducedfowlcholeramortalityinbroilers AT shovonlalsarkar novelmultistrainprobioticsreducespasteurellamultocidainducedfowlcholeramortalityinbroilers AT habibaibnat novelmultistrainprobioticsreducespasteurellamultocidainducedfowlcholeramortalityinbroilers AT mdaliahasansetu novelmultistrainprobioticsreducespasteurellamultocidainducedfowlcholeramortalityinbroilers AT pravaschandraroy novelmultistrainprobioticsreducespasteurellamultocidainducedfowlcholeramortalityinbroilers AT iqbalkabirjahid novelmultistrainprobioticsreducespasteurellamultocidainducedfowlcholeramortalityinbroilers
_version_	1718392637828890624

Novel multi-strain probiotics reduces Pasteurella multocida induced fowl cholera mortality in broilers

Ejemplares similares