Analysis of the role of METTL5 as a hub gene in lung adenocarcinoma based on a weighted gene co-expression network

Lung adenocarcinoma (LUAD) is a frequently diagnosed malignant tumor that is highly invasive and lethal. The prognosis of patients with LUAD still needs to be improved, as conventional treatment is remarkably well tolerated. In this study, the expression profile of LUAD in the TCGA database was used...

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Autores principales:	Xinwang Yan, Xiaowen Zhao, Qing Yan, Ye Wang, Chunling Zhang
Formato:	article
Lenguaje:	EN
Publicado:	AIMS Press 2021
Materias:	weighted gene co-expression network analysis lung adenocarcinoma mettl5 ddx23 cancer genome map Biotechnology TP248.13-248.65 Mathematics QA1-939
Acceso en línea:	https://doaj.org/article/ae1136983fc14371bf60d2720b3b2702
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spelling	oai:doaj.org-article:ae1136983fc14371bf60d2720b3b27022021-11-11T01:59:14ZAnalysis of the role of METTL5 as a hub gene in lung adenocarcinoma based on a weighted gene co-expression network10.3934/mbe.20213271551-0018https://doaj.org/article/ae1136983fc14371bf60d2720b3b27022021-08-01T00:00:00Zhttps://www.aimspress.com/article/doi/10.3934/mbe.2021327?viewType=HTMLhttps://doaj.org/toc/1551-0018Lung adenocarcinoma (LUAD) is a frequently diagnosed malignant tumor that is highly invasive and lethal. The prognosis of patients with LUAD still needs to be improved, as conventional treatment is remarkably well tolerated. In this study, the expression profile of LUAD in the TCGA database was used for differential expression analysis, and differential expression genes were determined to construct a weighted gene co-expression network analysis (WGCNA) for dividing and finding the gene modules with the highest correlation with tumor stage. Here, METTL5, DDX23, GPSM2, CEP95, WDCP, and METL17 were identified as hub genes. According to the relation degree, METTL5 was determined as the candidate gene in this study. Difference analysis and receiver operating characteristic (ROC) curve were applied to identify the predictive performance of METTL5 in LUAD, and Kaplan-Meier (KM) analysis showed that the prognosis of LUAD patients with high METTL5 expression was poor. Further GSEA analysis showed that high-expressed METTL5 was related to epithelial-mesenchymal transition and other pathways. Therefore, METTL5 may be involved in the occurrence and malignant progression of LUAD. The current findings provide an effective molecular target for early diagnosis of LUAD, helping monitor the malignant progression of LUAD and improve the prognosis of LUAD patients.Xinwang YanXiaowen ZhaoQing YanYe WangChunling ZhangAIMS Pressarticleweighted gene co-expression network analysislung adenocarcinomamettl5ddx23cancer genome mapBiotechnologyTP248.13-248.65MathematicsQA1-939ENMathematical Biosciences and Engineering, Vol 18, Iss 5, Pp 6608-6619 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	weighted gene co-expression network analysis lung adenocarcinoma mettl5 ddx23 cancer genome map Biotechnology TP248.13-248.65 Mathematics QA1-939
spellingShingle	weighted gene co-expression network analysis lung adenocarcinoma mettl5 ddx23 cancer genome map Biotechnology TP248.13-248.65 Mathematics QA1-939 Xinwang Yan Xiaowen Zhao Qing Yan Ye Wang Chunling Zhang Analysis of the role of METTL5 as a hub gene in lung adenocarcinoma based on a weighted gene co-expression network
description	Lung adenocarcinoma (LUAD) is a frequently diagnosed malignant tumor that is highly invasive and lethal. The prognosis of patients with LUAD still needs to be improved, as conventional treatment is remarkably well tolerated. In this study, the expression profile of LUAD in the TCGA database was used for differential expression analysis, and differential expression genes were determined to construct a weighted gene co-expression network analysis (WGCNA) for dividing and finding the gene modules with the highest correlation with tumor stage. Here, METTL5, DDX23, GPSM2, CEP95, WDCP, and METL17 were identified as hub genes. According to the relation degree, METTL5 was determined as the candidate gene in this study. Difference analysis and receiver operating characteristic (ROC) curve were applied to identify the predictive performance of METTL5 in LUAD, and Kaplan-Meier (KM) analysis showed that the prognosis of LUAD patients with high METTL5 expression was poor. Further GSEA analysis showed that high-expressed METTL5 was related to epithelial-mesenchymal transition and other pathways. Therefore, METTL5 may be involved in the occurrence and malignant progression of LUAD. The current findings provide an effective molecular target for early diagnosis of LUAD, helping monitor the malignant progression of LUAD and improve the prognosis of LUAD patients.
format	article
author	Xinwang Yan Xiaowen Zhao Qing Yan Ye Wang Chunling Zhang
author_facet	Xinwang Yan Xiaowen Zhao Qing Yan Ye Wang Chunling Zhang
author_sort	Xinwang Yan
title	Analysis of the role of METTL5 as a hub gene in lung adenocarcinoma based on a weighted gene co-expression network
title_short	Analysis of the role of METTL5 as a hub gene in lung adenocarcinoma based on a weighted gene co-expression network
title_full	Analysis of the role of METTL5 as a hub gene in lung adenocarcinoma based on a weighted gene co-expression network
title_fullStr	Analysis of the role of METTL5 as a hub gene in lung adenocarcinoma based on a weighted gene co-expression network
title_full_unstemmed	Analysis of the role of METTL5 as a hub gene in lung adenocarcinoma based on a weighted gene co-expression network
title_sort	analysis of the role of mettl5 as a hub gene in lung adenocarcinoma based on a weighted gene co-expression network
publisher	AIMS Press
publishDate	2021
url	https://doaj.org/article/ae1136983fc14371bf60d2720b3b2702
work_keys_str_mv	AT xinwangyan analysisoftheroleofmettl5asahubgeneinlungadenocarcinomabasedonaweightedgenecoexpressionnetwork AT xiaowenzhao analysisoftheroleofmettl5asahubgeneinlungadenocarcinomabasedonaweightedgenecoexpressionnetwork AT qingyan analysisoftheroleofmettl5asahubgeneinlungadenocarcinomabasedonaweightedgenecoexpressionnetwork AT yewang analysisoftheroleofmettl5asahubgeneinlungadenocarcinomabasedonaweightedgenecoexpressionnetwork AT chunlingzhang analysisoftheroleofmettl5asahubgeneinlungadenocarcinomabasedonaweightedgenecoexpressionnetwork
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Analysis of the role of METTL5 as a hub gene in lung adenocarcinoma based on a weighted gene co-expression network

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