Optical coherence tomography angiography in choroidal melanoma and nevus

Fariba Ghassemi,1,2 Reza Mirshahi,1,2 Kaveh Fadakar,1,2 Siamak Sabour3 1Retina & Vitreous Service, 2Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, 3Safety Promotion and Injury Prevention Research Centre, Department of Clinical Epidemiology, Shahid Beheshti...

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Autores principales:	Ghassemi F, Mirshahi R, Fadakar K, Sabour S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Choroidal melanoma Choroidal nevus OCT angiography OCTA Uveal melanoma Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/ae129d57f9b94a12820b95d6287ac85e
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spelling	oai:doaj.org-article:ae129d57f9b94a12820b95d6287ac85e2021-12-02T00:26:28ZOptical coherence tomography angiography in choroidal melanoma and nevus1177-5483https://doaj.org/article/ae129d57f9b94a12820b95d6287ac85e2018-01-01T00:00:00Zhttps://www.dovepress.com/optical-coherence-tomography-angiography-in-choroidal-melanoma-and-nev-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Fariba Ghassemi,1,2 Reza Mirshahi,1,2 Kaveh Fadakar,1,2 Siamak Sabour3 1Retina & Vitreous Service, 2Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, 3Safety Promotion and Injury Prevention Research Centre, Department of Clinical Epidemiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran Synopsis: In optical coherence tomography angiography, the choroidal vascular flow rate in choroidal melanoma is significantly lower than that in choroidal nevus.Objective: The objective of this study was to describe the choriocapillaris and retinal features imaged by optical coherence tomography angiography (OCTA) in eyes with choroidal nevus from small malignant choroidal melanoma.Methods: In this retrospective, noninvasive, observational study, 11 patients diagnosed with small choroidal mass (five with choroidal nevus and six with malignant melanoma) who underwent dilated fundus examination, ocular ultrasonography and OCTA images were compared.Results: In choroidal nevus of all patients, OCTA demonstrated a hyporeflective mass with no significant deformity of choroidal vasculature and an intact retinal pigment epithelium (RPE)–Bruch’s membrane complex. The flow void mass was surrounded by an intense vascular rim named as surface microvasculature (SMV) that had an approximately similar flow rate median of 63.68 mm2 (60.42–67.62 mm2), comparable with the median of the contralateral normal eye of 61.77 mm2 (60.42–64.53 mm2; P>0.09) for nevi. OCTA showed an obscured Bruch’s membrane–RPE–Bruch’s membrane complex and outer retinal layer in choroidal melanomas. Choriocapillaris flow rate over the melanomas was 55.73% (41.93%–60.82%), and the corresponding normal areas had a flow area of 62.75% (61.99%–63.10%; P=0.01). A flow rate difference between choroidal melanoma and nevus was significant (P=0.006). Axial and peripheral feeding vessels were more dilated and tortuous compared with benign nevi.Conclusion: Decreased flow rate of SMV of choroidal melanoma cases compared with nevi was a significant finding. Detection of characteristic vascular features of choroidal melanoma by OCTA could make OCTA an assuring diagnostic modality to differentiate malignant lesions. Keywords: melanoma, choroidal nevus, OCT, OCTA, uveal melanomaGhassemi FMirshahi RFadakar KSabour SDove Medical PressarticleChoroidal melanomaChoroidal nevusOCT angiographyOCTAUveal melanomaOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 207-214 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Choroidal melanoma Choroidal nevus OCT angiography OCTA Uveal melanoma Ophthalmology RE1-994
spellingShingle	Choroidal melanoma Choroidal nevus OCT angiography OCTA Uveal melanoma Ophthalmology RE1-994 Ghassemi F Mirshahi R Fadakar K Sabour S Optical coherence tomography angiography in choroidal melanoma and nevus
description	Fariba Ghassemi,1,2 Reza Mirshahi,1,2 Kaveh Fadakar,1,2 Siamak Sabour3 1Retina & Vitreous Service, 2Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, 3Safety Promotion and Injury Prevention Research Centre, Department of Clinical Epidemiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran Synopsis: In optical coherence tomography angiography, the choroidal vascular flow rate in choroidal melanoma is significantly lower than that in choroidal nevus.Objective: The objective of this study was to describe the choriocapillaris and retinal features imaged by optical coherence tomography angiography (OCTA) in eyes with choroidal nevus from small malignant choroidal melanoma.Methods: In this retrospective, noninvasive, observational study, 11 patients diagnosed with small choroidal mass (five with choroidal nevus and six with malignant melanoma) who underwent dilated fundus examination, ocular ultrasonography and OCTA images were compared.Results: In choroidal nevus of all patients, OCTA demonstrated a hyporeflective mass with no significant deformity of choroidal vasculature and an intact retinal pigment epithelium (RPE)–Bruch’s membrane complex. The flow void mass was surrounded by an intense vascular rim named as surface microvasculature (SMV) that had an approximately similar flow rate median of 63.68 mm2 (60.42–67.62 mm2), comparable with the median of the contralateral normal eye of 61.77 mm2 (60.42–64.53 mm2; P>0.09) for nevi. OCTA showed an obscured Bruch’s membrane–RPE–Bruch’s membrane complex and outer retinal layer in choroidal melanomas. Choriocapillaris flow rate over the melanomas was 55.73% (41.93%–60.82%), and the corresponding normal areas had a flow area of 62.75% (61.99%–63.10%; P=0.01). A flow rate difference between choroidal melanoma and nevus was significant (P=0.006). Axial and peripheral feeding vessels were more dilated and tortuous compared with benign nevi.Conclusion: Decreased flow rate of SMV of choroidal melanoma cases compared with nevi was a significant finding. Detection of characteristic vascular features of choroidal melanoma by OCTA could make OCTA an assuring diagnostic modality to differentiate malignant lesions. Keywords: melanoma, choroidal nevus, OCT, OCTA, uveal melanoma
format	article
author	Ghassemi F Mirshahi R Fadakar K Sabour S
author_facet	Ghassemi F Mirshahi R Fadakar K Sabour S
author_sort	Ghassemi F
title	Optical coherence tomography angiography in choroidal melanoma and nevus
title_short	Optical coherence tomography angiography in choroidal melanoma and nevus
title_full	Optical coherence tomography angiography in choroidal melanoma and nevus
title_fullStr	Optical coherence tomography angiography in choroidal melanoma and nevus
title_full_unstemmed	Optical coherence tomography angiography in choroidal melanoma and nevus
title_sort	optical coherence tomography angiography in choroidal melanoma and nevus
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/ae129d57f9b94a12820b95d6287ac85e
work_keys_str_mv	AT ghassemif opticalcoherencetomographyangiographyinchoroidalmelanomaandnevus AT mirshahir opticalcoherencetomographyangiographyinchoroidalmelanomaandnevus AT fadakark opticalcoherencetomographyangiographyinchoroidalmelanomaandnevus AT sabours opticalcoherencetomographyangiographyinchoroidalmelanomaandnevus
_version_	1718403759721152512

Optical coherence tomography angiography in choroidal melanoma and nevus

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