Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution

Resolution of granulomas in mycobacterial infection requires macrophages to switch from cytokine to nitric oxide (NO) production. Here the authors show that Mincle stimulates translation of the key NO synthesis genes by a mechanism dependent on p38-mediated hypusination of eiF5A.

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Main Authors:	Wook-Bin Lee, Ji-Seon Kang, Won Young Choi, Quanri Zhang, Chul Han Kim, Un Yung Choi, Jeongsil Kim-Ha, Young-Joon Kim
Format:	article
Language:	EN
Published:	Nature Portfolio 2016
Subjects:	Science Q
Online Access:	https://doaj.org/article/ae17c8e545c24eaeac56e1a53a11d707
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id	oai:doaj.org-article:ae17c8e545c24eaeac56e1a53a11d707
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spelling	oai:doaj.org-article:ae17c8e545c24eaeac56e1a53a11d7072021-12-02T16:50:55ZMincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution10.1038/ncomms113222041-1723https://doaj.org/article/ae17c8e545c24eaeac56e1a53a11d7072016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11322https://doaj.org/toc/2041-1723Resolution of granulomas in mycobacterial infection requires macrophages to switch from cytokine to nitric oxide (NO) production. Here the authors show that Mincle stimulates translation of the key NO synthesis genes by a mechanism dependent on p38-mediated hypusination of eiF5A.Wook-Bin LeeJi-Seon KangWon Young ChoiQuanri ZhangChul Han KimUn Yung ChoiJeongsil Kim-HaYoung-Joon KimNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wook-Bin Lee Ji-Seon Kang Won Young Choi Quanri Zhang Chul Han Kim Un Yung Choi Jeongsil Kim-Ha Young-Joon Kim Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution
description	Resolution of granulomas in mycobacterial infection requires macrophages to switch from cytokine to nitric oxide (NO) production. Here the authors show that Mincle stimulates translation of the key NO synthesis genes by a mechanism dependent on p38-mediated hypusination of eiF5A.
format	article
author	Wook-Bin Lee Ji-Seon Kang Won Young Choi Quanri Zhang Chul Han Kim Un Yung Choi Jeongsil Kim-Ha Young-Joon Kim
author_facet	Wook-Bin Lee Ji-Seon Kang Won Young Choi Quanri Zhang Chul Han Kim Un Yung Choi Jeongsil Kim-Ha Young-Joon Kim
author_sort	Wook-Bin Lee
title	Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution
title_short	Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution
title_full	Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution
title_fullStr	Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution
title_full_unstemmed	Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution
title_sort	mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/ae17c8e545c24eaeac56e1a53a11d707
work_keys_str_mv	AT wookbinlee minclemediatedtranslationalregulationisrequiredforstrongnitricoxideproductionandinflammationresolution AT jiseonkang minclemediatedtranslationalregulationisrequiredforstrongnitricoxideproductionandinflammationresolution AT wonyoungchoi minclemediatedtranslationalregulationisrequiredforstrongnitricoxideproductionandinflammationresolution AT quanrizhang minclemediatedtranslationalregulationisrequiredforstrongnitricoxideproductionandinflammationresolution AT chulhankim minclemediatedtranslationalregulationisrequiredforstrongnitricoxideproductionandinflammationresolution AT unyungchoi minclemediatedtranslationalregulationisrequiredforstrongnitricoxideproductionandinflammationresolution AT jeongsilkimha minclemediatedtranslationalregulationisrequiredforstrongnitricoxideproductionandinflammationresolution AT youngjoonkim minclemediatedtranslationalregulationisrequiredforstrongnitricoxideproductionandinflammationresolution
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Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution

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