Preparation and antioxidant properties of selenium nanoparticles-loaded chitosan microspheres

Kaikai Bai,1,2 Bihong Hong,1,2 Jianlin He,1,2 Zhuan Hong,1,2 Ran Tan1,2 1Third Institute of Oceanography, 2Engineering Research Center of Marine Biological Resource, Comprehensive Utilization, State Oceanic Administration, Xiamen, People’s Republic of China Abstract: Selenium nanoparticle...

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Autores principales:	Bai K, Hong B, He J, Hong Z, Tan R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	selenium nano microsphere chitosan antioxidant Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ae1c065c196e444db156a41d0ac01361
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spelling	oai:doaj.org-article:ae1c065c196e444db156a41d0ac013612021-12-02T00:38:48ZPreparation and antioxidant properties of selenium nanoparticles-loaded chitosan microspheres1178-2013https://doaj.org/article/ae1c065c196e444db156a41d0ac013612017-06-01T00:00:00Zhttps://www.dovepress.com/preparation-and-antioxidant-properties-of-selenium-nanoparticles-loade-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Kaikai Bai,1,2 Bihong Hong,1,2 Jianlin He,1,2 Zhuan Hong,1,2 Ran Tan1,2 1Third Institute of Oceanography, 2Engineering Research Center of Marine Biological Resource, Comprehensive Utilization, State Oceanic Administration, Xiamen, People’s Republic of China Abstract: Selenium nanoparticles (SeNPs), as a special form of selenium (Se) supplement, have attracted worldwide attention due to their favorable properties and unique bioactivities. Herein, an eco-friendly and economic way to prepare stable SeNPs is introduced. SeNPs were synthesized in aqueous chitosan (CTS) and then embedded into CTS microspheres by spray-drying, forming selenium nanoparticles-loaded chitosan microspheres (SeNPs-M). The physicochemical properties including morphology, elemental state, size distribution and surface potential were investigated. Institute of Cancer Research mice were used as model animal to evaluate the bioactivities of SeNPs-M. Trigonal-phase SeNPs of ~35 nm were synthesized, and SeNPs-M physically embedding those SeNPs were successfully prepared. Amazingly, acute toxicity test indicated that SeNPs-M were much safer than selenite in terms of Se dose, with a LD50 of around 18-fold of that of selenite. In addition, SeNPs-M possessed powerful antioxidant activities, as evidenced by a dramatic increase of both Se retention and the levels of glutathione peroxidase, superoxide dismutase and catalase. The design of SeNPs-M can offer a new way for further development of SeNPs with a higher efficacy and better biosafety. Thus, SeNPs-M may be a potential candidate for further evaluation as an Se supplement with antioxidant properties and be used against Se deficiency in animals and human beings. Keywords: selenium, nano, microsphere, chitosan, antioxidantBai KHong BHe JHong ZTan RDove Medical PressarticleseleniumnanomicrospherechitosanantioxidantMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 4527-4539 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	selenium nano microsphere chitosan antioxidant Medicine (General) R5-920
spellingShingle	selenium nano microsphere chitosan antioxidant Medicine (General) R5-920 Bai K Hong B He J Hong Z Tan R Preparation and antioxidant properties of selenium nanoparticles-loaded chitosan microspheres
description	Kaikai Bai,1,2 Bihong Hong,1,2 Jianlin He,1,2 Zhuan Hong,1,2 Ran Tan1,2 1Third Institute of Oceanography, 2Engineering Research Center of Marine Biological Resource, Comprehensive Utilization, State Oceanic Administration, Xiamen, People’s Republic of China Abstract: Selenium nanoparticles (SeNPs), as a special form of selenium (Se) supplement, have attracted worldwide attention due to their favorable properties and unique bioactivities. Herein, an eco-friendly and economic way to prepare stable SeNPs is introduced. SeNPs were synthesized in aqueous chitosan (CTS) and then embedded into CTS microspheres by spray-drying, forming selenium nanoparticles-loaded chitosan microspheres (SeNPs-M). The physicochemical properties including morphology, elemental state, size distribution and surface potential were investigated. Institute of Cancer Research mice were used as model animal to evaluate the bioactivities of SeNPs-M. Trigonal-phase SeNPs of ~35 nm were synthesized, and SeNPs-M physically embedding those SeNPs were successfully prepared. Amazingly, acute toxicity test indicated that SeNPs-M were much safer than selenite in terms of Se dose, with a LD50 of around 18-fold of that of selenite. In addition, SeNPs-M possessed powerful antioxidant activities, as evidenced by a dramatic increase of both Se retention and the levels of glutathione peroxidase, superoxide dismutase and catalase. The design of SeNPs-M can offer a new way for further development of SeNPs with a higher efficacy and better biosafety. Thus, SeNPs-M may be a potential candidate for further evaluation as an Se supplement with antioxidant properties and be used against Se deficiency in animals and human beings. Keywords: selenium, nano, microsphere, chitosan, antioxidant
format	article
author	Bai K Hong B He J Hong Z Tan R
author_facet	Bai K Hong B He J Hong Z Tan R
author_sort	Bai K
title	Preparation and antioxidant properties of selenium nanoparticles-loaded chitosan microspheres
title_short	Preparation and antioxidant properties of selenium nanoparticles-loaded chitosan microspheres
title_full	Preparation and antioxidant properties of selenium nanoparticles-loaded chitosan microspheres
title_fullStr	Preparation and antioxidant properties of selenium nanoparticles-loaded chitosan microspheres
title_full_unstemmed	Preparation and antioxidant properties of selenium nanoparticles-loaded chitosan microspheres
title_sort	preparation and antioxidant properties of selenium nanoparticles-loaded chitosan microspheres
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/ae1c065c196e444db156a41d0ac01361
work_keys_str_mv	AT baik preparationandantioxidantpropertiesofseleniumnanoparticlesloadedchitosanmicrospheres AT hongb preparationandantioxidantpropertiesofseleniumnanoparticlesloadedchitosanmicrospheres AT hej preparationandantioxidantpropertiesofseleniumnanoparticlesloadedchitosanmicrospheres AT hongz preparationandantioxidantpropertiesofseleniumnanoparticlesloadedchitosanmicrospheres AT tanr preparationandantioxidantpropertiesofseleniumnanoparticlesloadedchitosanmicrospheres
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Preparation and antioxidant properties of selenium nanoparticles-loaded chitosan microspheres

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