A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model
Amyotrophic lateral sclerosis (ALS) is a neurological disease that leads to loss of voluntary muscle movement. Here, the authors screen for molecules that disrupt interaction between SOD1, a protein linked to ALS, and Derlin-1, and find an inhibitor that reduces pathology in an ALS mouse model.
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Nature Portfolio
2018
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oai:doaj.org-article:ae1dd53d987140b484aa532c904097812021-12-02T16:56:54ZA small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model10.1038/s41467-018-05127-22041-1723https://doaj.org/article/ae1dd53d987140b484aa532c904097812018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05127-2https://doaj.org/toc/2041-1723Amyotrophic lateral sclerosis (ALS) is a neurological disease that leads to loss of voluntary muscle movement. Here, the authors screen for molecules that disrupt interaction between SOD1, a protein linked to ALS, and Derlin-1, and find an inhibitor that reduces pathology in an ALS mouse model.Naomi TsuburayaKengo HommaTsunehiko HiguchiAndrii BaliaHiroyuki YamakoshiNorio ShibataSeiichi NakamuraHidehiko NakagawaShin-ichi IkedaNaoki UmezawaNobuki KatoSatoshi YokoshimaMasatoshi ShibuyaManabu ShimonishiHirotatsu KojimaTakayoshi OkabeTetsuo NaganoIsao NaguroKeiko ImamuraHaruhisa InoueTakao FujisawaHidenori IchijoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018) |
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Science Q |
| spellingShingle |
Science Q Naomi Tsuburaya Kengo Homma Tsunehiko Higuchi Andrii Balia Hiroyuki Yamakoshi Norio Shibata Seiichi Nakamura Hidehiko Nakagawa Shin-ichi Ikeda Naoki Umezawa Nobuki Kato Satoshi Yokoshima Masatoshi Shibuya Manabu Shimonishi Hirotatsu Kojima Takayoshi Okabe Tetsuo Nagano Isao Naguro Keiko Imamura Haruhisa Inoue Takao Fujisawa Hidenori Ichijo A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model |
| description |
Amyotrophic lateral sclerosis (ALS) is a neurological disease that leads to loss of voluntary muscle movement. Here, the authors screen for molecules that disrupt interaction between SOD1, a protein linked to ALS, and Derlin-1, and find an inhibitor that reduces pathology in an ALS mouse model. |
| format |
article |
| author |
Naomi Tsuburaya Kengo Homma Tsunehiko Higuchi Andrii Balia Hiroyuki Yamakoshi Norio Shibata Seiichi Nakamura Hidehiko Nakagawa Shin-ichi Ikeda Naoki Umezawa Nobuki Kato Satoshi Yokoshima Masatoshi Shibuya Manabu Shimonishi Hirotatsu Kojima Takayoshi Okabe Tetsuo Nagano Isao Naguro Keiko Imamura Haruhisa Inoue Takao Fujisawa Hidenori Ichijo |
| author_facet |
Naomi Tsuburaya Kengo Homma Tsunehiko Higuchi Andrii Balia Hiroyuki Yamakoshi Norio Shibata Seiichi Nakamura Hidehiko Nakagawa Shin-ichi Ikeda Naoki Umezawa Nobuki Kato Satoshi Yokoshima Masatoshi Shibuya Manabu Shimonishi Hirotatsu Kojima Takayoshi Okabe Tetsuo Nagano Isao Naguro Keiko Imamura Haruhisa Inoue Takao Fujisawa Hidenori Ichijo |
| author_sort |
Naomi Tsuburaya |
| title |
A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model |
| title_short |
A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model |
| title_full |
A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model |
| title_fullStr |
A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model |
| title_full_unstemmed |
A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model |
| title_sort |
small-molecule inhibitor of sod1-derlin-1 interaction ameliorates pathology in an als mouse model |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/ae1dd53d987140b484aa532c90409781 |
| work_keys_str_mv |
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