Cognitive function in peripheral autonomic disorders.

<h4>Objective</h4>aims of the current study were 1) to evaluate global cognitive function in patients with autonomic failure (AF) of peripheral origin and 2) to investigate the effect of a documented fall in blood pressure (BP) fulfilling the criteria for orthostatic hypotension (OH) on...

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Autores principales:	Pietro Guaraldi, Roberto Poda, Giovanna Calandra-Buonaura, Laura Solieri, Luisa Sambati, Roberto Gallassi, Pietro Cortelli
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ae1e1b2365a349d9a11a0d6918df405c
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spelling	oai:doaj.org-article:ae1e1b2365a349d9a11a0d6918df405c2021-11-18T08:37:29ZCognitive function in peripheral autonomic disorders.1932-620310.1371/journal.pone.0085020https://doaj.org/article/ae1e1b2365a349d9a11a0d6918df405c2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24465471/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>aims of the current study were 1) to evaluate global cognitive function in patients with autonomic failure (AF) of peripheral origin and 2) to investigate the effect of a documented fall in blood pressure (BP) fulfilling the criteria for orthostatic hypotension (OH) on cognitive performances.<h4>Methods</h4>we assessed 12 consecutive patients (10 males, 68±7 years old) with pure AF (PAF) or autoimmune autonomic neuropathy (AAN) and 12 age- and gender-matched controls. All patients had no clinical signs of central nervous system involvement and normal brain CT/MRI scan. Cognitive function was assessed on two consecutive days in 3 conditions: on day 1, while sitting, by means of a comprehensive battery of neuropsychological tests; on day 2, while tilted (HUT) and during supine rest (supine) in a randomized manner. BP and heart rate (HR) were continuously recorded non-invasively for the whole duration of the examination.<h4>Results</h4>patients with PAF or AAN displayed a preserved global cognitive function while sitting. However, compared to supine assessment, during HUT patients scored significantly worse during the Trail Making Test A and B, Barrage test, Analogies test, Immediate Visual Memory, Span Forward and Span Backward test. Pathological scores, with regard to Italian normative range values, were observed only during HUT in the Barrage test and in the Analogies test in 3 and 6 patients respectively. On the contrary, in healthy controls, results to neuropsychological tests were not significantly different, during HUT compared to supine rest.<h4>Conclusions</h4>these data demonstrate that patients with PAF and AAN present a normal sitting global cognitive evaluation. However, their executive functions worsen significantly during the orthostatic challenge, possibly because of transient frontal lobes hypoperfusion.Pietro GuaraldiRoberto PodaGiovanna Calandra-BuonauraLaura SolieriLuisa SambatiRoberto GallassiPietro CortelliPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e85020 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pietro Guaraldi Roberto Poda Giovanna Calandra-Buonaura Laura Solieri Luisa Sambati Roberto Gallassi Pietro Cortelli Cognitive function in peripheral autonomic disorders.
description	<h4>Objective</h4>aims of the current study were 1) to evaluate global cognitive function in patients with autonomic failure (AF) of peripheral origin and 2) to investigate the effect of a documented fall in blood pressure (BP) fulfilling the criteria for orthostatic hypotension (OH) on cognitive performances.<h4>Methods</h4>we assessed 12 consecutive patients (10 males, 68±7 years old) with pure AF (PAF) or autoimmune autonomic neuropathy (AAN) and 12 age- and gender-matched controls. All patients had no clinical signs of central nervous system involvement and normal brain CT/MRI scan. Cognitive function was assessed on two consecutive days in 3 conditions: on day 1, while sitting, by means of a comprehensive battery of neuropsychological tests; on day 2, while tilted (HUT) and during supine rest (supine) in a randomized manner. BP and heart rate (HR) were continuously recorded non-invasively for the whole duration of the examination.<h4>Results</h4>patients with PAF or AAN displayed a preserved global cognitive function while sitting. However, compared to supine assessment, during HUT patients scored significantly worse during the Trail Making Test A and B, Barrage test, Analogies test, Immediate Visual Memory, Span Forward and Span Backward test. Pathological scores, with regard to Italian normative range values, were observed only during HUT in the Barrage test and in the Analogies test in 3 and 6 patients respectively. On the contrary, in healthy controls, results to neuropsychological tests were not significantly different, during HUT compared to supine rest.<h4>Conclusions</h4>these data demonstrate that patients with PAF and AAN present a normal sitting global cognitive evaluation. However, their executive functions worsen significantly during the orthostatic challenge, possibly because of transient frontal lobes hypoperfusion.
format	article
author	Pietro Guaraldi Roberto Poda Giovanna Calandra-Buonaura Laura Solieri Luisa Sambati Roberto Gallassi Pietro Cortelli
author_facet	Pietro Guaraldi Roberto Poda Giovanna Calandra-Buonaura Laura Solieri Luisa Sambati Roberto Gallassi Pietro Cortelli
author_sort	Pietro Guaraldi
title	Cognitive function in peripheral autonomic disorders.
title_short	Cognitive function in peripheral autonomic disorders.
title_full	Cognitive function in peripheral autonomic disorders.
title_fullStr	Cognitive function in peripheral autonomic disorders.
title_full_unstemmed	Cognitive function in peripheral autonomic disorders.
title_sort	cognitive function in peripheral autonomic disorders.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/ae1e1b2365a349d9a11a0d6918df405c
work_keys_str_mv	AT pietroguaraldi cognitivefunctioninperipheralautonomicdisorders AT robertopoda cognitivefunctioninperipheralautonomicdisorders AT giovannacalandrabuonaura cognitivefunctioninperipheralautonomicdisorders AT laurasolieri cognitivefunctioninperipheralautonomicdisorders AT luisasambati cognitivefunctioninperipheralautonomicdisorders AT robertogallassi cognitivefunctioninperipheralautonomicdisorders AT pietrocortelli cognitivefunctioninperipheralautonomicdisorders
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Cognitive function in peripheral autonomic disorders.

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