miRNA as a Modulator of Immunotherapy and Immune Response in Melanoma

Immune checkpoint inhibitors are a promising therapy for the treatment of cancers, including melanoma, that improved benefit clinical outcomes. However, a subset of melanoma patients do not respond or acquire resistance to immunotherapy, which limits their clinical applicability. Recent studies have...

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Autores principales:	Mai-Huong Thi Nguyen, Yueh-Hsia Luo, An-Lun Li, Jen-Chieh Tsai, Kun-Lin Wu, Pei-Jung Chung, Nianhan Ma
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	immunotherapy resistance miRNA biomarker Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/ae1ff9ce822d4e288d12818cefbb94dc
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spelling	oai:doaj.org-article:ae1ff9ce822d4e288d12818cefbb94dc2021-11-25T16:53:22ZmiRNA as a Modulator of Immunotherapy and Immune Response in Melanoma10.3390/biom111116482218-273Xhttps://doaj.org/article/ae1ff9ce822d4e288d12818cefbb94dc2021-11-01T00:00:00Zhttps://www.mdpi.com/2218-273X/11/11/1648https://doaj.org/toc/2218-273XImmune checkpoint inhibitors are a promising therapy for the treatment of cancers, including melanoma, that improved benefit clinical outcomes. However, a subset of melanoma patients do not respond or acquire resistance to immunotherapy, which limits their clinical applicability. Recent studies have explored the reasons related to the resistance of melanoma to immune checkpoint inhibitors. Of note, miRNAs are the regulators of not only cancer progression but also of the response between cancer cells and immune cells. Investigation of miRNA functions within the tumor microenvironment have suggested that miRNAs could be considered as key partners in immunotherapy. Here, we reviewed the known mechanism by which melanoma induces resistance to immunotherapy and the role of miRNAs in immune responses and the microenvironment.Mai-Huong Thi NguyenYueh-Hsia LuoAn-Lun LiJen-Chieh TsaiKun-Lin WuPei-Jung ChungNianhan MaMDPI AGarticleimmunotherapyresistancemiRNAbiomarkerMicrobiologyQR1-502ENBiomolecules, Vol 11, Iss 1648, p 1648 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	immunotherapy resistance miRNA biomarker Microbiology QR1-502
spellingShingle	immunotherapy resistance miRNA biomarker Microbiology QR1-502 Mai-Huong Thi Nguyen Yueh-Hsia Luo An-Lun Li Jen-Chieh Tsai Kun-Lin Wu Pei-Jung Chung Nianhan Ma miRNA as a Modulator of Immunotherapy and Immune Response in Melanoma
description	Immune checkpoint inhibitors are a promising therapy for the treatment of cancers, including melanoma, that improved benefit clinical outcomes. However, a subset of melanoma patients do not respond or acquire resistance to immunotherapy, which limits their clinical applicability. Recent studies have explored the reasons related to the resistance of melanoma to immune checkpoint inhibitors. Of note, miRNAs are the regulators of not only cancer progression but also of the response between cancer cells and immune cells. Investigation of miRNA functions within the tumor microenvironment have suggested that miRNAs could be considered as key partners in immunotherapy. Here, we reviewed the known mechanism by which melanoma induces resistance to immunotherapy and the role of miRNAs in immune responses and the microenvironment.
format	article
author	Mai-Huong Thi Nguyen Yueh-Hsia Luo An-Lun Li Jen-Chieh Tsai Kun-Lin Wu Pei-Jung Chung Nianhan Ma
author_facet	Mai-Huong Thi Nguyen Yueh-Hsia Luo An-Lun Li Jen-Chieh Tsai Kun-Lin Wu Pei-Jung Chung Nianhan Ma
author_sort	Mai-Huong Thi Nguyen
title	miRNA as a Modulator of Immunotherapy and Immune Response in Melanoma
title_short	miRNA as a Modulator of Immunotherapy and Immune Response in Melanoma
title_full	miRNA as a Modulator of Immunotherapy and Immune Response in Melanoma
title_fullStr	miRNA as a Modulator of Immunotherapy and Immune Response in Melanoma
title_full_unstemmed	miRNA as a Modulator of Immunotherapy and Immune Response in Melanoma
title_sort	mirna as a modulator of immunotherapy and immune response in melanoma
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ae1ff9ce822d4e288d12818cefbb94dc
work_keys_str_mv	AT maihuongthinguyen mirnaasamodulatorofimmunotherapyandimmuneresponseinmelanoma AT yuehhsialuo mirnaasamodulatorofimmunotherapyandimmuneresponseinmelanoma AT anlunli mirnaasamodulatorofimmunotherapyandimmuneresponseinmelanoma AT jenchiehtsai mirnaasamodulatorofimmunotherapyandimmuneresponseinmelanoma AT kunlinwu mirnaasamodulatorofimmunotherapyandimmuneresponseinmelanoma AT peijungchung mirnaasamodulatorofimmunotherapyandimmuneresponseinmelanoma AT nianhanma mirnaasamodulatorofimmunotherapyandimmuneresponseinmelanoma
_version_	1718412915806044160

miRNA as a Modulator of Immunotherapy and Immune Response in Melanoma

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