Pan-cancer analysis of SETD2 mutation and its association with the efficacy of immunotherapy

Abstract Histone methyltransferase SETD2 plays a critical role in maintaining genomic integrity and stability. Here, we investigated the characteristics of SETD2 somatic mutation in the cancer genome atlas pan-cancer cohort. Our data revealed that, compared with SETD2 nonmutant patients, SETD2 mutan...

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Autores principales:	Mingdong Lu, Bin Zhao, Mengshan Liu, Le Wu, Yingying Li, Yingna Zhai, Xian Shen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/ae21fcd0412c44bda93ebc0cd806c6e7
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spelling	oai:doaj.org-article:ae21fcd0412c44bda93ebc0cd806c6e72021-12-02T17:40:41ZPan-cancer analysis of SETD2 mutation and its association with the efficacy of immunotherapy10.1038/s41698-021-00193-02397-768Xhttps://doaj.org/article/ae21fcd0412c44bda93ebc0cd806c6e72021-06-01T00:00:00Zhttps://doi.org/10.1038/s41698-021-00193-0https://doaj.org/toc/2397-768XAbstract Histone methyltransferase SETD2 plays a critical role in maintaining genomic integrity and stability. Here, we investigated the characteristics of SETD2 somatic mutation in the cancer genome atlas pan-cancer cohort. Our data revealed that, compared with SETD2 nonmutant patients, SETD2 mutant patients had higher tumor mutation burden and microsatellite instability. In addition, the transcriptions of most genes related to immune activities were upregulated in patients with SETD2 mutant tumors. Further examination of cancer patients treated with immune checkpoint inhibitors suggested SETD2 mutation was associated with favorable clinical outcomes. These results have implication for the personalization of cancer immunotherapy.Mingdong LuBin ZhaoMengshan LiuLe WuYingying LiYingna ZhaiXian ShenNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Precision Oncology, Vol 5, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Mingdong Lu Bin Zhao Mengshan Liu Le Wu Yingying Li Yingna Zhai Xian Shen Pan-cancer analysis of SETD2 mutation and its association with the efficacy of immunotherapy
description	Abstract Histone methyltransferase SETD2 plays a critical role in maintaining genomic integrity and stability. Here, we investigated the characteristics of SETD2 somatic mutation in the cancer genome atlas pan-cancer cohort. Our data revealed that, compared with SETD2 nonmutant patients, SETD2 mutant patients had higher tumor mutation burden and microsatellite instability. In addition, the transcriptions of most genes related to immune activities were upregulated in patients with SETD2 mutant tumors. Further examination of cancer patients treated with immune checkpoint inhibitors suggested SETD2 mutation was associated with favorable clinical outcomes. These results have implication for the personalization of cancer immunotherapy.
format	article
author	Mingdong Lu Bin Zhao Mengshan Liu Le Wu Yingying Li Yingna Zhai Xian Shen
author_facet	Mingdong Lu Bin Zhao Mengshan Liu Le Wu Yingying Li Yingna Zhai Xian Shen
author_sort	Mingdong Lu
title	Pan-cancer analysis of SETD2 mutation and its association with the efficacy of immunotherapy
title_short	Pan-cancer analysis of SETD2 mutation and its association with the efficacy of immunotherapy
title_full	Pan-cancer analysis of SETD2 mutation and its association with the efficacy of immunotherapy
title_fullStr	Pan-cancer analysis of SETD2 mutation and its association with the efficacy of immunotherapy
title_full_unstemmed	Pan-cancer analysis of SETD2 mutation and its association with the efficacy of immunotherapy
title_sort	pan-cancer analysis of setd2 mutation and its association with the efficacy of immunotherapy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ae21fcd0412c44bda93ebc0cd806c6e7
work_keys_str_mv	AT mingdonglu pancanceranalysisofsetd2mutationanditsassociationwiththeefficacyofimmunotherapy AT binzhao pancanceranalysisofsetd2mutationanditsassociationwiththeefficacyofimmunotherapy AT mengshanliu pancanceranalysisofsetd2mutationanditsassociationwiththeefficacyofimmunotherapy AT lewu pancanceranalysisofsetd2mutationanditsassociationwiththeefficacyofimmunotherapy AT yingyingli pancanceranalysisofsetd2mutationanditsassociationwiththeefficacyofimmunotherapy AT yingnazhai pancanceranalysisofsetd2mutationanditsassociationwiththeefficacyofimmunotherapy AT xianshen pancanceranalysisofsetd2mutationanditsassociationwiththeefficacyofimmunotherapy
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Pan-cancer analysis of SETD2 mutation and its association with the efficacy of immunotherapy

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