P50, the small subunit of DNA polymerase delta, is required for mediation of the interaction of polymerase delta subassemblies with PCNA.

P50, the small subunit of DNA polymerase delta, is required for mediation of the interaction of polymerase delta subassemblies with PCNA.

Mammalian DNA polymerase δ (pol δ), a four-subunit enzyme, plays a crucial and versatile role in DNA replication and various DNA repair processes. Its function as a chromosomal DNA polymerase is dependent on the association with proliferating cell nuclear antigen (PCNA) which functions as a molecula...

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Autores principales: Yujue Wang, Qian Zhang, Huiqing Chen, Xiao Li, Weijun Mai, Keping Chen, Sufang Zhang, Ernest Y C Lee, Marietta Y W T Lee, Yajing Zhou
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/ae2234a9f8a3421ba80d4b5f31efda4a
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