Serum miRNA signature diagnoses and discriminates murine colitis subtypes and predicts ulcerative colitis in humans
Abstract Inflammatory bowel disease (IBD) is difficult to diagnose due to nonspecific and variable symptoms, and lack of reliable diagnostic tests. Current methods are invasive, non-sensitive, non-predictive, and do not easily discriminate between its two main forms. Consequently, there remains a gr...
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Nature Portfolio
2017
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oai:doaj.org-article:ae240fd4a54240fc99acb54a6dce06c92021-12-02T11:53:02ZSerum miRNA signature diagnoses and discriminates murine colitis subtypes and predicts ulcerative colitis in humans10.1038/s41598-017-02782-12045-2322https://doaj.org/article/ae240fd4a54240fc99acb54a6dce06c92017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02782-1https://doaj.org/toc/2045-2322Abstract Inflammatory bowel disease (IBD) is difficult to diagnose due to nonspecific and variable symptoms, and lack of reliable diagnostic tests. Current methods are invasive, non-sensitive, non-predictive, and do not easily discriminate between its two main forms. Consequently, there remains a great need for reliable serum markers for IBD. Here, using a longitudinal study of various mouse models of colitis, we identified a serum miRNA signature that indicated the development of colitis and discriminated between inflammations of various origins (colitis from arthritis). Unlike the existing biomarkers, the newly identified signature also serves to distinguish individuals at risk, predict the type of inflammation, and evaluate the response to therapeutics. Moreover, the miRNA signature identified in mice predicted ulcerative colitis with 83.3% accuracy. In future, the signature identified herein could play a central role in monitoring inflammatory disorders and therapeutic responses in patients, thereby paving the way for personalized medicine.Emilie ViennoisYuan ZhaoMoon Kwon HanBo XiaoMingzhen ZhangMeena PrasadLixin WangDidier MerlinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-16 (2017) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Emilie Viennois Yuan Zhao Moon Kwon Han Bo Xiao Mingzhen Zhang Meena Prasad Lixin Wang Didier Merlin Serum miRNA signature diagnoses and discriminates murine colitis subtypes and predicts ulcerative colitis in humans |
| description |
Abstract Inflammatory bowel disease (IBD) is difficult to diagnose due to nonspecific and variable symptoms, and lack of reliable diagnostic tests. Current methods are invasive, non-sensitive, non-predictive, and do not easily discriminate between its two main forms. Consequently, there remains a great need for reliable serum markers for IBD. Here, using a longitudinal study of various mouse models of colitis, we identified a serum miRNA signature that indicated the development of colitis and discriminated between inflammations of various origins (colitis from arthritis). Unlike the existing biomarkers, the newly identified signature also serves to distinguish individuals at risk, predict the type of inflammation, and evaluate the response to therapeutics. Moreover, the miRNA signature identified in mice predicted ulcerative colitis with 83.3% accuracy. In future, the signature identified herein could play a central role in monitoring inflammatory disorders and therapeutic responses in patients, thereby paving the way for personalized medicine. |
| format |
article |
| author |
Emilie Viennois Yuan Zhao Moon Kwon Han Bo Xiao Mingzhen Zhang Meena Prasad Lixin Wang Didier Merlin |
| author_facet |
Emilie Viennois Yuan Zhao Moon Kwon Han Bo Xiao Mingzhen Zhang Meena Prasad Lixin Wang Didier Merlin |
| author_sort |
Emilie Viennois |
| title |
Serum miRNA signature diagnoses and discriminates murine colitis subtypes and predicts ulcerative colitis in humans |
| title_short |
Serum miRNA signature diagnoses and discriminates murine colitis subtypes and predicts ulcerative colitis in humans |
| title_full |
Serum miRNA signature diagnoses and discriminates murine colitis subtypes and predicts ulcerative colitis in humans |
| title_fullStr |
Serum miRNA signature diagnoses and discriminates murine colitis subtypes and predicts ulcerative colitis in humans |
| title_full_unstemmed |
Serum miRNA signature diagnoses and discriminates murine colitis subtypes and predicts ulcerative colitis in humans |
| title_sort |
serum mirna signature diagnoses and discriminates murine colitis subtypes and predicts ulcerative colitis in humans |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/ae240fd4a54240fc99acb54a6dce06c9 |
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