ACTH- and cortisol-associated neutrophil modulation in coronary artery disease patients undergoing stent implantation.

<h4>Background</h4>Psychosocial stress and activation of neutrophil granulocytes are increasingly recognized as major risk factors of coronary artery disease (CAD), but the possible relationship of these two factors in CAD patients is largely unexplored. Activation of neutrophils was rep...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Margit Keresztes, Tamás Horváth, Imre Ocsovszki, Imre Földesi, Gyöngyi Serfőző, Krisztina Boda, Imre Ungi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ae2791611cc545379f4d0c8103093a8b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ae2791611cc545379f4d0c8103093a8b
record_format	dspace
spelling	oai:doaj.org-article:ae2791611cc545379f4d0c8103093a8b2021-11-18T08:59:39ZACTH- and cortisol-associated neutrophil modulation in coronary artery disease patients undergoing stent implantation.1932-620310.1371/journal.pone.0071902https://doaj.org/article/ae2791611cc545379f4d0c8103093a8b2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23967262/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Psychosocial stress and activation of neutrophil granulocytes are increasingly recognized as major risk factors of coronary artery disease (CAD), but the possible relationship of these two factors in CAD patients is largely unexplored. Activation of neutrophils was reported to be associated with stenting; however, the issue of neutrophil state in connection with percutaneous coronary intervention (PCI) is incompletely understood from the aspect of stress and its hypothalamic-pituitary-adrenal axis (HPA) background. Thus, we aimed to study cortisol- and ACTH-associated changes in granulocyte activation in patients undergoing PCI.<h4>Methodology/principal findings</h4>Blood samples of 21 stable angina pectoris (SAP) and 20 acute coronary syndrome (ACS) patients were collected directly before (pre-PCI), after (post-PCI) and on the following day of PCI (1d-PCI). Granulocyte surface L-selectin, CD15 and (neutrophil-specific) lactoferrin were analysed by flow cytometry. Plasma cortisol, ACTH, and lactoferrin, IL-6 were also assayed. In both groups, pre- and post-PCI ratios of lactoferrin-bearing neutrophils were relatively high, these percentages decreased substantially next day; similarly, 1d-PCI plasma lactoferrin was about half of the post-PCI value (all p≤0.0001). Post-PCI ACTH was reduced markedly next day, especially in ACS group (SAP: p<0.01, ACS: p≤0.0001). In ACS, elevated pre-PCI cortisol decreased considerably a day after stenting (p<0.01); in pre-PCI samples, cortisol correlated with plasma lactoferrin (r∼0.5, p<0.05). In 1d-PCI samples of both groups, ACTH showed negative associations with the ratio of lactoferrin-bearing neutrophils (SAP: r = -0.601, p<0.005; ACS: r = -0.541, p<0.05) and with plasma lactoferrin (SAP: r = -0.435, p<0.05; ACS: r = -0.609, p<0.005).<h4>Conclusions/significance</h4>Pre- and post-PCI states were associated with increased percentage of activated/degranulated neutrophils indicated by elevated lactoferrin parameters, the 1d-PCI declines of which were associated with plasma ACTH in both groups. The correlation of plasma cortisol with plasma lactoferrin in the extremely stressed ACS before stenting, however, suggests an association of cortisol with neutrophil activation.Margit KeresztesTamás HorváthImre OcsovszkiImre FöldesiGyöngyi SerfőzőKrisztina BodaImre UngiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 8, p e71902 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Margit Keresztes Tamás Horváth Imre Ocsovszki Imre Földesi Gyöngyi Serfőző Krisztina Boda Imre Ungi ACTH- and cortisol-associated neutrophil modulation in coronary artery disease patients undergoing stent implantation.
description	<h4>Background</h4>Psychosocial stress and activation of neutrophil granulocytes are increasingly recognized as major risk factors of coronary artery disease (CAD), but the possible relationship of these two factors in CAD patients is largely unexplored. Activation of neutrophils was reported to be associated with stenting; however, the issue of neutrophil state in connection with percutaneous coronary intervention (PCI) is incompletely understood from the aspect of stress and its hypothalamic-pituitary-adrenal axis (HPA) background. Thus, we aimed to study cortisol- and ACTH-associated changes in granulocyte activation in patients undergoing PCI.<h4>Methodology/principal findings</h4>Blood samples of 21 stable angina pectoris (SAP) and 20 acute coronary syndrome (ACS) patients were collected directly before (pre-PCI), after (post-PCI) and on the following day of PCI (1d-PCI). Granulocyte surface L-selectin, CD15 and (neutrophil-specific) lactoferrin were analysed by flow cytometry. Plasma cortisol, ACTH, and lactoferrin, IL-6 were also assayed. In both groups, pre- and post-PCI ratios of lactoferrin-bearing neutrophils were relatively high, these percentages decreased substantially next day; similarly, 1d-PCI plasma lactoferrin was about half of the post-PCI value (all p≤0.0001). Post-PCI ACTH was reduced markedly next day, especially in ACS group (SAP: p<0.01, ACS: p≤0.0001). In ACS, elevated pre-PCI cortisol decreased considerably a day after stenting (p<0.01); in pre-PCI samples, cortisol correlated with plasma lactoferrin (r∼0.5, p<0.05). In 1d-PCI samples of both groups, ACTH showed negative associations with the ratio of lactoferrin-bearing neutrophils (SAP: r = -0.601, p<0.005; ACS: r = -0.541, p<0.05) and with plasma lactoferrin (SAP: r = -0.435, p<0.05; ACS: r = -0.609, p<0.005).<h4>Conclusions/significance</h4>Pre- and post-PCI states were associated with increased percentage of activated/degranulated neutrophils indicated by elevated lactoferrin parameters, the 1d-PCI declines of which were associated with plasma ACTH in both groups. The correlation of plasma cortisol with plasma lactoferrin in the extremely stressed ACS before stenting, however, suggests an association of cortisol with neutrophil activation.
format	article
author	Margit Keresztes Tamás Horváth Imre Ocsovszki Imre Földesi Gyöngyi Serfőző Krisztina Boda Imre Ungi
author_facet	Margit Keresztes Tamás Horváth Imre Ocsovszki Imre Földesi Gyöngyi Serfőző Krisztina Boda Imre Ungi
author_sort	Margit Keresztes
title	ACTH- and cortisol-associated neutrophil modulation in coronary artery disease patients undergoing stent implantation.
title_short	ACTH- and cortisol-associated neutrophil modulation in coronary artery disease patients undergoing stent implantation.
title_full	ACTH- and cortisol-associated neutrophil modulation in coronary artery disease patients undergoing stent implantation.
title_fullStr	ACTH- and cortisol-associated neutrophil modulation in coronary artery disease patients undergoing stent implantation.
title_full_unstemmed	ACTH- and cortisol-associated neutrophil modulation in coronary artery disease patients undergoing stent implantation.
title_sort	acth- and cortisol-associated neutrophil modulation in coronary artery disease patients undergoing stent implantation.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/ae2791611cc545379f4d0c8103093a8b
work_keys_str_mv	AT margitkeresztes acthandcortisolassociatedneutrophilmodulationincoronaryarterydiseasepatientsundergoingstentimplantation AT tamashorvath acthandcortisolassociatedneutrophilmodulationincoronaryarterydiseasepatientsundergoingstentimplantation AT imreocsovszki acthandcortisolassociatedneutrophilmodulationincoronaryarterydiseasepatientsundergoingstentimplantation AT imrefoldesi acthandcortisolassociatedneutrophilmodulationincoronaryarterydiseasepatientsundergoingstentimplantation AT gyongyiserfozo acthandcortisolassociatedneutrophilmodulationincoronaryarterydiseasepatientsundergoingstentimplantation AT krisztinaboda acthandcortisolassociatedneutrophilmodulationincoronaryarterydiseasepatientsundergoingstentimplantation AT imreungi acthandcortisolassociatedneutrophilmodulationincoronaryarterydiseasepatientsundergoingstentimplantation
_version_	1718421042647531520

ACTH- and cortisol-associated neutrophil modulation in coronary artery disease patients undergoing stent implantation.

Ejemplares similares