DsbA-L mediated renal tubulointerstitial fibrosis in UUO mice

DsbA-L mediated renal tubulointerstitial fibrosis in UUO mice

DsbA-L upregulation prevents lipid-induced renal injury in diabetic nephropathy. Here, the authors show that DsbA-L knockout attenuates tubulointerstitial fibrosis in mice, and show that this occurs via activation of Smad3 and p53, which result in modulation of CTGF, a regulator of kidney fibrosis.

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Detalles Bibliográficos
Autores principales: Xiaozhou Li, Jian Pan, Huiling Li, Guangdi Li, Xiangfeng Liu, Bohao Liu, Zhibiao He, Zhengyu Peng, Hongliang Zhang, Yijian Li, Xudong Xiang, Xiangping Chai, Yunchang Yuan, Peilin Zheng, Feng Liu, Dongshan Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/ae280dd3997a4201992ebb94a4b819a9
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Descripción
Sumario:DsbA-L upregulation prevents lipid-induced renal injury in diabetic nephropathy. Here, the authors show that DsbA-L knockout attenuates tubulointerstitial fibrosis in mice, and show that this occurs via activation of Smad3 and p53, which result in modulation of CTGF, a regulator of kidney fibrosis.

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