DsbA-L mediated renal tubulointerstitial fibrosis in UUO mice

DsbA-L mediated renal tubulointerstitial fibrosis in UUO mice

DsbA-L upregulation prevents lipid-induced renal injury in diabetic nephropathy. Here, the authors show that DsbA-L knockout attenuates tubulointerstitial fibrosis in mice, and show that this occurs via activation of Smad3 and p53, which result in modulation of CTGF, a regulator of kidney fibrosis.

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Autores principales: Xiaozhou Li, Jian Pan, Huiling Li, Guangdi Li, Xiangfeng Liu, Bohao Liu, Zhibiao He, Zhengyu Peng, Hongliang Zhang, Yijian Li, Xudong Xiang, Xiangping Chai, Yunchang Yuan, Peilin Zheng, Feng Liu, Dongshan Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
Q
Acceso en línea:https://doaj.org/article/ae280dd3997a4201992ebb94a4b819a9
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spelling oai:doaj.org-article:ae280dd3997a4201992ebb94a4b819a92021-12-02T15:16:06ZDsbA-L mediated renal tubulointerstitial fibrosis in UUO mice10.1038/s41467-020-18304-z2041-1723https://doaj.org/article/ae280dd3997a4201992ebb94a4b819a92020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18304-zhttps://doaj.org/toc/2041-1723DsbA-L upregulation prevents lipid-induced renal injury in diabetic nephropathy. Here, the authors show that DsbA-L knockout attenuates tubulointerstitial fibrosis in mice, and show that this occurs via activation of Smad3 and p53, which result in modulation of CTGF, a regulator of kidney fibrosis.Xiaozhou LiJian PanHuiling LiGuangdi LiXiangfeng LiuBohao LiuZhibiao HeZhengyu PengHongliang ZhangYijian LiXudong XiangXiangping ChaiYunchang YuanPeilin ZhengFeng LiuDongshan ZhangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xiaozhou Li
Jian Pan
Huiling Li
Guangdi Li
Xiangfeng Liu
Bohao Liu
Zhibiao He
Zhengyu Peng
Hongliang Zhang
Yijian Li
Xudong Xiang
Xiangping Chai
Yunchang Yuan
Peilin Zheng
Feng Liu
Dongshan Zhang
DsbA-L mediated renal tubulointerstitial fibrosis in UUO mice
description DsbA-L upregulation prevents lipid-induced renal injury in diabetic nephropathy. Here, the authors show that DsbA-L knockout attenuates tubulointerstitial fibrosis in mice, and show that this occurs via activation of Smad3 and p53, which result in modulation of CTGF, a regulator of kidney fibrosis.
format article
author Xiaozhou Li
Jian Pan
Huiling Li
Guangdi Li
Xiangfeng Liu
Bohao Liu
Zhibiao He
Zhengyu Peng
Hongliang Zhang
Yijian Li
Xudong Xiang
Xiangping Chai
Yunchang Yuan
Peilin Zheng
Feng Liu
Dongshan Zhang
author_facet Xiaozhou Li
Jian Pan
Huiling Li
Guangdi Li
Xiangfeng Liu
Bohao Liu
Zhibiao He
Zhengyu Peng
Hongliang Zhang
Yijian Li
Xudong Xiang
Xiangping Chai
Yunchang Yuan
Peilin Zheng
Feng Liu
Dongshan Zhang
author_sort Xiaozhou Li
title DsbA-L mediated renal tubulointerstitial fibrosis in UUO mice
title_short DsbA-L mediated renal tubulointerstitial fibrosis in UUO mice
title_full DsbA-L mediated renal tubulointerstitial fibrosis in UUO mice
title_fullStr DsbA-L mediated renal tubulointerstitial fibrosis in UUO mice
title_full_unstemmed DsbA-L mediated renal tubulointerstitial fibrosis in UUO mice
title_sort dsba-l mediated renal tubulointerstitial fibrosis in uuo mice
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/ae280dd3997a4201992ebb94a4b819a9
work_keys_str_mv AT xiaozhouli dsbalmediatedrenaltubulointerstitialfibrosisinuuomice
AT jianpan dsbalmediatedrenaltubulointerstitialfibrosisinuuomice
AT huilingli dsbalmediatedrenaltubulointerstitialfibrosisinuuomice
AT guangdili dsbalmediatedrenaltubulointerstitialfibrosisinuuomice
AT xiangfengliu dsbalmediatedrenaltubulointerstitialfibrosisinuuomice
AT bohaoliu dsbalmediatedrenaltubulointerstitialfibrosisinuuomice
AT zhibiaohe dsbalmediatedrenaltubulointerstitialfibrosisinuuomice
AT zhengyupeng dsbalmediatedrenaltubulointerstitialfibrosisinuuomice
AT hongliangzhang dsbalmediatedrenaltubulointerstitialfibrosisinuuomice
AT yijianli dsbalmediatedrenaltubulointerstitialfibrosisinuuomice
AT xudongxiang dsbalmediatedrenaltubulointerstitialfibrosisinuuomice
AT xiangpingchai dsbalmediatedrenaltubulointerstitialfibrosisinuuomice
AT yunchangyuan dsbalmediatedrenaltubulointerstitialfibrosisinuuomice
AT peilinzheng dsbalmediatedrenaltubulointerstitialfibrosisinuuomice
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