Glucocorticoid receptor signaling in ventral tegmental area neurons increases the rewarding value of a high-fat diet in mice
Abstract The reward system, which consists of dopaminergic neurons projecting from the ventral tegmental area (VTA) to the nucleus accumbens and caudate-putamen in the striatum, has an important role in the pathogenesis of not only drug addiction but also diet-induced obesity. In the present study,...
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2021
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oai:doaj.org-article:ae289dbba7b74dd890748749693f2b762021-12-02T17:40:46ZGlucocorticoid receptor signaling in ventral tegmental area neurons increases the rewarding value of a high-fat diet in mice10.1038/s41598-021-92386-72045-2322https://doaj.org/article/ae289dbba7b74dd890748749693f2b762021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92386-7https://doaj.org/toc/2045-2322Abstract The reward system, which consists of dopaminergic neurons projecting from the ventral tegmental area (VTA) to the nucleus accumbens and caudate-putamen in the striatum, has an important role in the pathogenesis of not only drug addiction but also diet-induced obesity. In the present study, we examined whether signaling through glucocorticoid receptors (GRs) in the reward system affects the rewarding value of a high-fat diet (HFD). To do so, we generated mice that lack functional GRs specifically in dopaminergic neurons (D-KO mice) or corticostriatal neurons (CS-KO mice), subjected the mice to caloric restriction stress conditions, and evaluated the rewarding value of a HFD by conditioned place preference (CPP) test. Caloric restriction induced increases in serum corticosterone to similar levels in all genotypes. While CS-KO as well as WT mice exhibited a significant preference for HFD in the CPP test, D-KO mice exhibited no such preference. There were no differences between WT and D-KO mice in consumption of HFD after fasting or cognitive function evaluated by a novel object recognition test. These data suggest that glucocorticoid signaling in the VTA increases the rewarding value of a HFD under restricted caloric stress.Akira MizoguchiRyoichi BannoRunan SunHiroshi YaginumaKeigo TakiTomoko KobayashiMariko SugiyamaTaku TsunekawaTakeshi OnoueHiroshi TakagiDaisuke HagiwaraYoshihiro ItoShintaro IwamaHidetaka SugaTaku NagaiKiyofumi YamadaHiroshi ArimaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021) |
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Medicine R Science Q Akira Mizoguchi Ryoichi Banno Runan Sun Hiroshi Yaginuma Keigo Taki Tomoko Kobayashi Mariko Sugiyama Taku Tsunekawa Takeshi Onoue Hiroshi Takagi Daisuke Hagiwara Yoshihiro Ito Shintaro Iwama Hidetaka Suga Taku Nagai Kiyofumi Yamada Hiroshi Arima Glucocorticoid receptor signaling in ventral tegmental area neurons increases the rewarding value of a high-fat diet in mice |
| description |
Abstract The reward system, which consists of dopaminergic neurons projecting from the ventral tegmental area (VTA) to the nucleus accumbens and caudate-putamen in the striatum, has an important role in the pathogenesis of not only drug addiction but also diet-induced obesity. In the present study, we examined whether signaling through glucocorticoid receptors (GRs) in the reward system affects the rewarding value of a high-fat diet (HFD). To do so, we generated mice that lack functional GRs specifically in dopaminergic neurons (D-KO mice) or corticostriatal neurons (CS-KO mice), subjected the mice to caloric restriction stress conditions, and evaluated the rewarding value of a HFD by conditioned place preference (CPP) test. Caloric restriction induced increases in serum corticosterone to similar levels in all genotypes. While CS-KO as well as WT mice exhibited a significant preference for HFD in the CPP test, D-KO mice exhibited no such preference. There were no differences between WT and D-KO mice in consumption of HFD after fasting or cognitive function evaluated by a novel object recognition test. These data suggest that glucocorticoid signaling in the VTA increases the rewarding value of a HFD under restricted caloric stress. |
| format |
article |
| author |
Akira Mizoguchi Ryoichi Banno Runan Sun Hiroshi Yaginuma Keigo Taki Tomoko Kobayashi Mariko Sugiyama Taku Tsunekawa Takeshi Onoue Hiroshi Takagi Daisuke Hagiwara Yoshihiro Ito Shintaro Iwama Hidetaka Suga Taku Nagai Kiyofumi Yamada Hiroshi Arima |
| author_facet |
Akira Mizoguchi Ryoichi Banno Runan Sun Hiroshi Yaginuma Keigo Taki Tomoko Kobayashi Mariko Sugiyama Taku Tsunekawa Takeshi Onoue Hiroshi Takagi Daisuke Hagiwara Yoshihiro Ito Shintaro Iwama Hidetaka Suga Taku Nagai Kiyofumi Yamada Hiroshi Arima |
| author_sort |
Akira Mizoguchi |
| title |
Glucocorticoid receptor signaling in ventral tegmental area neurons increases the rewarding value of a high-fat diet in mice |
| title_short |
Glucocorticoid receptor signaling in ventral tegmental area neurons increases the rewarding value of a high-fat diet in mice |
| title_full |
Glucocorticoid receptor signaling in ventral tegmental area neurons increases the rewarding value of a high-fat diet in mice |
| title_fullStr |
Glucocorticoid receptor signaling in ventral tegmental area neurons increases the rewarding value of a high-fat diet in mice |
| title_full_unstemmed |
Glucocorticoid receptor signaling in ventral tegmental area neurons increases the rewarding value of a high-fat diet in mice |
| title_sort |
glucocorticoid receptor signaling in ventral tegmental area neurons increases the rewarding value of a high-fat diet in mice |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/ae289dbba7b74dd890748749693f2b76 |
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