Molecular determinants of response to PD-L1 blockade across tumor types

PD-L1 immune checkpoint inhibition has been used for several tumour types. Here, the authors use immunohistochemistry, tumour mutation burden and RNA-seq data from 366 patients with different indications to identify molecular signatures of response to atezolizumab and reveal pathway heterogeneity an...

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Autores principales:	Romain Banchereau, Ning Leng, Oliver Zill, Ethan Sokol, Gengbo Liu, Dean Pavlick, Sophia Maund, Li-Fen Liu, Edward Kadel, Nicole Baldwin, Suchit Jhunjhunwala, Dorothee Nickles, Zoe June Assaf, Daniel Bower, Namrata Patil, Mark McCleland, David Shames, Luciana Molinero, Mahrukh Huseni, Shomyseh Sanjabi, Craig Cummings, Ira Mellman, Sanjeev Mariathasan, Priti Hegde, Thomas Powles
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ae29efdfced64f11b4172bdb2e1a8bde
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spelling	oai:doaj.org-article:ae29efdfced64f11b4172bdb2e1a8bde2021-12-02T17:12:24ZMolecular determinants of response to PD-L1 blockade across tumor types10.1038/s41467-021-24112-w2041-1723https://doaj.org/article/ae29efdfced64f11b4172bdb2e1a8bde2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24112-whttps://doaj.org/toc/2041-1723PD-L1 immune checkpoint inhibition has been used for several tumour types. Here, the authors use immunohistochemistry, tumour mutation burden and RNA-seq data from 366 patients with different indications to identify molecular signatures of response to atezolizumab and reveal pathway heterogeneity and the involvement of non-immune pathways.Romain BanchereauNing LengOliver ZillEthan SokolGengbo LiuDean PavlickSophia MaundLi-Fen LiuEdward KadelNicole BaldwinSuchit JhunjhunwalaDorothee NicklesZoe June AssafDaniel BowerNamrata PatilMark McClelandDavid ShamesLuciana MolineroMahrukh HuseniShomyseh SanjabiCraig CummingsIra MellmanSanjeev MariathasanPriti HegdeThomas PowlesNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Romain Banchereau Ning Leng Oliver Zill Ethan Sokol Gengbo Liu Dean Pavlick Sophia Maund Li-Fen Liu Edward Kadel Nicole Baldwin Suchit Jhunjhunwala Dorothee Nickles Zoe June Assaf Daniel Bower Namrata Patil Mark McCleland David Shames Luciana Molinero Mahrukh Huseni Shomyseh Sanjabi Craig Cummings Ira Mellman Sanjeev Mariathasan Priti Hegde Thomas Powles Molecular determinants of response to PD-L1 blockade across tumor types
description	PD-L1 immune checkpoint inhibition has been used for several tumour types. Here, the authors use immunohistochemistry, tumour mutation burden and RNA-seq data from 366 patients with different indications to identify molecular signatures of response to atezolizumab and reveal pathway heterogeneity and the involvement of non-immune pathways.
format	article
author	Romain Banchereau Ning Leng Oliver Zill Ethan Sokol Gengbo Liu Dean Pavlick Sophia Maund Li-Fen Liu Edward Kadel Nicole Baldwin Suchit Jhunjhunwala Dorothee Nickles Zoe June Assaf Daniel Bower Namrata Patil Mark McCleland David Shames Luciana Molinero Mahrukh Huseni Shomyseh Sanjabi Craig Cummings Ira Mellman Sanjeev Mariathasan Priti Hegde Thomas Powles
author_facet	Romain Banchereau Ning Leng Oliver Zill Ethan Sokol Gengbo Liu Dean Pavlick Sophia Maund Li-Fen Liu Edward Kadel Nicole Baldwin Suchit Jhunjhunwala Dorothee Nickles Zoe June Assaf Daniel Bower Namrata Patil Mark McCleland David Shames Luciana Molinero Mahrukh Huseni Shomyseh Sanjabi Craig Cummings Ira Mellman Sanjeev Mariathasan Priti Hegde Thomas Powles
author_sort	Romain Banchereau
title	Molecular determinants of response to PD-L1 blockade across tumor types
title_short	Molecular determinants of response to PD-L1 blockade across tumor types
title_full	Molecular determinants of response to PD-L1 blockade across tumor types
title_fullStr	Molecular determinants of response to PD-L1 blockade across tumor types
title_full_unstemmed	Molecular determinants of response to PD-L1 blockade across tumor types
title_sort	molecular determinants of response to pd-l1 blockade across tumor types
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ae29efdfced64f11b4172bdb2e1a8bde
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Molecular determinants of response to PD-L1 blockade across tumor types

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