Robust estimates of overall immune-repertoire diversity from high-throughput measurements on samples

Diversity of an organism’s B- and T-cell repertoires is clinically important, but difficult to estimate due to uncertainty in the number of clones in a sample, sampling bias and experimental noise. Here Kaplinsky and Arnaout present Recon, a method that reconstructs the distribution of the overall r...

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Autores principales: Joseph Kaplinsky, Ramy Arnaout
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/ae2e1c7eadd7404eb1ccb3943358ec0a
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Sumario:Diversity of an organism’s B- and T-cell repertoires is clinically important, but difficult to estimate due to uncertainty in the number of clones in a sample, sampling bias and experimental noise. Here Kaplinsky and Arnaout present Recon, a method that reconstructs the distribution of the overall repertoire from sample measurements.