Robust estimates of overall immune-repertoire diversity from high-throughput measurements on samples

Diversity of an organism’s B- and T-cell repertoires is clinically important, but difficult to estimate due to uncertainty in the number of clones in a sample, sampling bias and experimental noise. Here Kaplinsky and Arnaout present Recon, a method that reconstructs the distribution of the overall r...

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Autores principales:	Joseph Kaplinsky, Ramy Arnaout
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ae2e1c7eadd7404eb1ccb3943358ec0a
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spelling	oai:doaj.org-article:ae2e1c7eadd7404eb1ccb3943358ec0a2021-12-02T14:40:15ZRobust estimates of overall immune-repertoire diversity from high-throughput measurements on samples10.1038/ncomms118812041-1723https://doaj.org/article/ae2e1c7eadd7404eb1ccb3943358ec0a2016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11881https://doaj.org/toc/2041-1723Diversity of an organism’s B- and T-cell repertoires is clinically important, but difficult to estimate due to uncertainty in the number of clones in a sample, sampling bias and experimental noise. Here Kaplinsky and Arnaout present Recon, a method that reconstructs the distribution of the overall repertoire from sample measurements.Joseph KaplinskyRamy ArnaoutNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joseph Kaplinsky Ramy Arnaout Robust estimates of overall immune-repertoire diversity from high-throughput measurements on samples
description	Diversity of an organism’s B- and T-cell repertoires is clinically important, but difficult to estimate due to uncertainty in the number of clones in a sample, sampling bias and experimental noise. Here Kaplinsky and Arnaout present Recon, a method that reconstructs the distribution of the overall repertoire from sample measurements.
format	article
author	Joseph Kaplinsky Ramy Arnaout
author_facet	Joseph Kaplinsky Ramy Arnaout
author_sort	Joseph Kaplinsky
title	Robust estimates of overall immune-repertoire diversity from high-throughput measurements on samples
title_short	Robust estimates of overall immune-repertoire diversity from high-throughput measurements on samples
title_full	Robust estimates of overall immune-repertoire diversity from high-throughput measurements on samples
title_fullStr	Robust estimates of overall immune-repertoire diversity from high-throughput measurements on samples
title_full_unstemmed	Robust estimates of overall immune-repertoire diversity from high-throughput measurements on samples
title_sort	robust estimates of overall immune-repertoire diversity from high-throughput measurements on samples
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/ae2e1c7eadd7404eb1ccb3943358ec0a
work_keys_str_mv	AT josephkaplinsky robustestimatesofoverallimmunerepertoirediversityfromhighthroughputmeasurementsonsamples AT ramyarnaout robustestimatesofoverallimmunerepertoirediversityfromhighthroughputmeasurementsonsamples
_version_	1718390375977058304

Robust estimates of overall immune-repertoire diversity from high-throughput measurements on samples

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