Bisphenol A Alters the Energy Metabolism of Stromal Cells and Could Promote Bladder Cancer Progression

Bisphenol A (BPA) is an endocrine-disrupting molecule used in plastics. Through its release in food and the environment, BPA can be found in humans and is mostly excreted in urine. The bladder is therefore continuously exposed to this compound. BPA can bind to multiple cell receptors involved in pro...

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Autores principales:	Ève Pellerin, Stéphane Chabaud, Frédéric Pouliot, Martin Pelletier, Stéphane Bolduc
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	bisphenol A cancer-associated fibroblasts bladder cancer metabolism glycolysis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/ae316927eea3441e9a13c40463027170
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spelling	oai:doaj.org-article:ae316927eea3441e9a13c404630271702021-11-11T15:33:31ZBisphenol A Alters the Energy Metabolism of Stromal Cells and Could Promote Bladder Cancer Progression10.3390/cancers132154612072-6694https://doaj.org/article/ae316927eea3441e9a13c404630271702021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5461https://doaj.org/toc/2072-6694Bisphenol A (BPA) is an endocrine-disrupting molecule used in plastics. Through its release in food and the environment, BPA can be found in humans and is mostly excreted in urine. The bladder is therefore continuously exposed to this compound. BPA can bind to multiple cell receptors involved in proliferation, migration and invasion pathways, and exposure to BPA is associated with cancer progression. Considering the physiological concentrations of BPA in urine, we tested the effect of nanomolar concentrations of BPA on the metabolism of bladder fibroblasts and cancer-associated fibroblasts (CAFs). Our results show that BPA led to a decreased metabolism in fibroblasts, which could alter the extracellular matrix. Furthermore, CAF induction triggered a metabolic switch, similar to the Warburg effect described in cancer cells. Additionally, we demonstrated that nanomolar concentrations of BPA could exacerbate this metabolic switch observed in CAFs via an increased glycolytic metabolism, leading to greater acidification of the extracellular environment. These findings suggest that chronic exposure to BPA could promote cancer progression through an alteration of the metabolism of stromal cells.Ève PellerinStéphane ChabaudFrédéric PouliotMartin PelletierStéphane BolducMDPI AGarticlebisphenol Acancer-associated fibroblastsbladder cancermetabolismglycolysisNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5461, p 5461 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bisphenol A cancer-associated fibroblasts bladder cancer metabolism glycolysis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	bisphenol A cancer-associated fibroblasts bladder cancer metabolism glycolysis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Ève Pellerin Stéphane Chabaud Frédéric Pouliot Martin Pelletier Stéphane Bolduc Bisphenol A Alters the Energy Metabolism of Stromal Cells and Could Promote Bladder Cancer Progression
description	Bisphenol A (BPA) is an endocrine-disrupting molecule used in plastics. Through its release in food and the environment, BPA can be found in humans and is mostly excreted in urine. The bladder is therefore continuously exposed to this compound. BPA can bind to multiple cell receptors involved in proliferation, migration and invasion pathways, and exposure to BPA is associated with cancer progression. Considering the physiological concentrations of BPA in urine, we tested the effect of nanomolar concentrations of BPA on the metabolism of bladder fibroblasts and cancer-associated fibroblasts (CAFs). Our results show that BPA led to a decreased metabolism in fibroblasts, which could alter the extracellular matrix. Furthermore, CAF induction triggered a metabolic switch, similar to the Warburg effect described in cancer cells. Additionally, we demonstrated that nanomolar concentrations of BPA could exacerbate this metabolic switch observed in CAFs via an increased glycolytic metabolism, leading to greater acidification of the extracellular environment. These findings suggest that chronic exposure to BPA could promote cancer progression through an alteration of the metabolism of stromal cells.
format	article
author	Ève Pellerin Stéphane Chabaud Frédéric Pouliot Martin Pelletier Stéphane Bolduc
author_facet	Ève Pellerin Stéphane Chabaud Frédéric Pouliot Martin Pelletier Stéphane Bolduc
author_sort	Ève Pellerin
title	Bisphenol A Alters the Energy Metabolism of Stromal Cells and Could Promote Bladder Cancer Progression
title_short	Bisphenol A Alters the Energy Metabolism of Stromal Cells and Could Promote Bladder Cancer Progression
title_full	Bisphenol A Alters the Energy Metabolism of Stromal Cells and Could Promote Bladder Cancer Progression
title_fullStr	Bisphenol A Alters the Energy Metabolism of Stromal Cells and Could Promote Bladder Cancer Progression
title_full_unstemmed	Bisphenol A Alters the Energy Metabolism of Stromal Cells and Could Promote Bladder Cancer Progression
title_sort	bisphenol a alters the energy metabolism of stromal cells and could promote bladder cancer progression
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ae316927eea3441e9a13c40463027170
work_keys_str_mv	AT evepellerin bisphenolaalterstheenergymetabolismofstromalcellsandcouldpromotebladdercancerprogression AT stephanechabaud bisphenolaalterstheenergymetabolismofstromalcellsandcouldpromotebladdercancerprogression AT fredericpouliot bisphenolaalterstheenergymetabolismofstromalcellsandcouldpromotebladdercancerprogression AT martinpelletier bisphenolaalterstheenergymetabolismofstromalcellsandcouldpromotebladdercancerprogression AT stephanebolduc bisphenolaalterstheenergymetabolismofstromalcellsandcouldpromotebladdercancerprogression
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Bisphenol A Alters the Energy Metabolism of Stromal Cells and Could Promote Bladder Cancer Progression

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