A Paradox in Digital Memory Assessment: Increased Sensitivity With Reduced Difficulty

The One Card Learning Test (OCL80) from the Cogstate Brief Battery—a digital cognitive test used both in-person and remotely in clinical trials and in healthcare contexts to inform health decisions—has shown high sensitivity to changes in memory in early Alzheimer's disease (AD). However, recen...

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Autores principales:	Joshua P. White, Adrian Schembri, Chris J. Edgar, Yen Ying Lim, Colin L. Masters, Paul Maruff
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	cognition digital biomarker memory Alzheimer's diagnosis Medicine R Public aspects of medicine RA1-1270 Electronic computers. Computer science QA75.5-76.95
Acceso en línea:	https://doaj.org/article/ae35bc55141840799e17357f2cf5423e
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spelling	oai:doaj.org-article:ae35bc55141840799e17357f2cf5423e2021-11-22T04:51:59ZA Paradox in Digital Memory Assessment: Increased Sensitivity With Reduced Difficulty2673-253X10.3389/fdgth.2021.780303https://doaj.org/article/ae35bc55141840799e17357f2cf5423e2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fdgth.2021.780303/fullhttps://doaj.org/toc/2673-253XThe One Card Learning Test (OCL80) from the Cogstate Brief Battery—a digital cognitive test used both in-person and remotely in clinical trials and in healthcare contexts to inform health decisions—has shown high sensitivity to changes in memory in early Alzheimer's disease (AD). However, recent studies suggest that OCL sensitivity to memory impairment in symptomatic AD is not as strong as that for other standardized assessments of memory. This study aimed to improve the sensitivity of the OCL80 to AD-related memory impairment by reducing the test difficultly (i.e., OCL48). Experiment 1 showed performance in healthy adults improved on the OCL48 while the pattern separation operations that constrain performance on the OCL80 were retained. Experiment 2 showed repeated administration of the OCL48 at short retest intervals did not induce ceiling or practice effects. Experiment 3 showed that the sensitivity of the OCL48 to AD-related memory impairment (Glass's Δ = 3.11) was much greater than the sensitivity of the OCL80 (Glass's Δ = 1.94). Experiment 4 used data from a large group of cognitively normal older adults to calibrate performance scores between the OCL80 and OCL48 using equipercentile equating. Together these results showed the OCL48 to be a valid and reliable test of learning with greater sensitivity to memory impairment in AD than the OCL80.Joshua P. WhiteAdrian SchembriChris J. EdgarYen Ying LimColin L. MastersPaul MaruffPaul MaruffFrontiers Media S.A.articlecognitiondigital biomarkermemoryAlzheimer'sdiagnosisMedicineRPublic aspects of medicineRA1-1270Electronic computers. Computer scienceQA75.5-76.95ENFrontiers in Digital Health, Vol 3 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cognition digital biomarker memory Alzheimer's diagnosis Medicine R Public aspects of medicine RA1-1270 Electronic computers. Computer science QA75.5-76.95
spellingShingle	cognition digital biomarker memory Alzheimer's diagnosis Medicine R Public aspects of medicine RA1-1270 Electronic computers. Computer science QA75.5-76.95 Joshua P. White Adrian Schembri Chris J. Edgar Yen Ying Lim Colin L. Masters Paul Maruff Paul Maruff A Paradox in Digital Memory Assessment: Increased Sensitivity With Reduced Difficulty
description	The One Card Learning Test (OCL80) from the Cogstate Brief Battery—a digital cognitive test used both in-person and remotely in clinical trials and in healthcare contexts to inform health decisions—has shown high sensitivity to changes in memory in early Alzheimer's disease (AD). However, recent studies suggest that OCL sensitivity to memory impairment in symptomatic AD is not as strong as that for other standardized assessments of memory. This study aimed to improve the sensitivity of the OCL80 to AD-related memory impairment by reducing the test difficultly (i.e., OCL48). Experiment 1 showed performance in healthy adults improved on the OCL48 while the pattern separation operations that constrain performance on the OCL80 were retained. Experiment 2 showed repeated administration of the OCL48 at short retest intervals did not induce ceiling or practice effects. Experiment 3 showed that the sensitivity of the OCL48 to AD-related memory impairment (Glass's Δ = 3.11) was much greater than the sensitivity of the OCL80 (Glass's Δ = 1.94). Experiment 4 used data from a large group of cognitively normal older adults to calibrate performance scores between the OCL80 and OCL48 using equipercentile equating. Together these results showed the OCL48 to be a valid and reliable test of learning with greater sensitivity to memory impairment in AD than the OCL80.
format	article
author	Joshua P. White Adrian Schembri Chris J. Edgar Yen Ying Lim Colin L. Masters Paul Maruff Paul Maruff
author_facet	Joshua P. White Adrian Schembri Chris J. Edgar Yen Ying Lim Colin L. Masters Paul Maruff Paul Maruff
author_sort	Joshua P. White
title	A Paradox in Digital Memory Assessment: Increased Sensitivity With Reduced Difficulty
title_short	A Paradox in Digital Memory Assessment: Increased Sensitivity With Reduced Difficulty
title_full	A Paradox in Digital Memory Assessment: Increased Sensitivity With Reduced Difficulty
title_fullStr	A Paradox in Digital Memory Assessment: Increased Sensitivity With Reduced Difficulty
title_full_unstemmed	A Paradox in Digital Memory Assessment: Increased Sensitivity With Reduced Difficulty
title_sort	paradox in digital memory assessment: increased sensitivity with reduced difficulty
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/ae35bc55141840799e17357f2cf5423e
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A Paradox in Digital Memory Assessment: Increased Sensitivity With Reduced Difficulty

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