Merlin is required for coordinating proliferation of two stem cell lineages in the Drosophila testis

Abstract Although the mechanisms that balance self-renewal and differentiation of a stem cell lineage have been extensively studied, it remains poorly understood how tissues that contain multiple stem cell lineages maintain balanced proliferation among distinct lineages: when stem cells of a particu...

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Autores principales:	Mayu Inaba, Dorothy R. Sorenson, Matt Kortus, Viktoria Salzmann, Yukiko M. Yamashita
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ae374bcc28e84f61a919fe475de156c8
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spelling	oai:doaj.org-article:ae374bcc28e84f61a919fe475de156c82021-12-02T15:05:37ZMerlin is required for coordinating proliferation of two stem cell lineages in the Drosophila testis10.1038/s41598-017-02768-z2045-2322https://doaj.org/article/ae374bcc28e84f61a919fe475de156c82017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02768-zhttps://doaj.org/toc/2045-2322Abstract Although the mechanisms that balance self-renewal and differentiation of a stem cell lineage have been extensively studied, it remains poorly understood how tissues that contain multiple stem cell lineages maintain balanced proliferation among distinct lineages: when stem cells of a particular lineage proliferate, how do the other lineages respond to maintain the correct ratio of cells among linages? Here, we show that Merlin (Mer), a homolog of the human tumor suppressor neurofibromatosis 2, is required to coordinate proliferation of germline stem cells (GSCs) and somatic cyst stem cells (CySCs) in the Drosophila testis. Mer mutant CySCs fail to coordinate their proliferation with that of GSCs in multiple settings, and can be triggered to undergo tumorous overproliferation. Mer executes its function by stabilizing adherens junctions. Given the known role of Mer in contact-dependent inhibition of proliferation, we propose that the proliferation of CySCs are regulated by crowdedness, or confluency, of cells in their lineage with respect to that of germline, thereby coordinating the proliferation of two lineages.Mayu InabaDorothy R. SorensonMatt KortusViktoria SalzmannYukiko M. YamashitaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mayu Inaba Dorothy R. Sorenson Matt Kortus Viktoria Salzmann Yukiko M. Yamashita Merlin is required for coordinating proliferation of two stem cell lineages in the Drosophila testis
description	Abstract Although the mechanisms that balance self-renewal and differentiation of a stem cell lineage have been extensively studied, it remains poorly understood how tissues that contain multiple stem cell lineages maintain balanced proliferation among distinct lineages: when stem cells of a particular lineage proliferate, how do the other lineages respond to maintain the correct ratio of cells among linages? Here, we show that Merlin (Mer), a homolog of the human tumor suppressor neurofibromatosis 2, is required to coordinate proliferation of germline stem cells (GSCs) and somatic cyst stem cells (CySCs) in the Drosophila testis. Mer mutant CySCs fail to coordinate their proliferation with that of GSCs in multiple settings, and can be triggered to undergo tumorous overproliferation. Mer executes its function by stabilizing adherens junctions. Given the known role of Mer in contact-dependent inhibition of proliferation, we propose that the proliferation of CySCs are regulated by crowdedness, or confluency, of cells in their lineage with respect to that of germline, thereby coordinating the proliferation of two lineages.
format	article
author	Mayu Inaba Dorothy R. Sorenson Matt Kortus Viktoria Salzmann Yukiko M. Yamashita
author_facet	Mayu Inaba Dorothy R. Sorenson Matt Kortus Viktoria Salzmann Yukiko M. Yamashita
author_sort	Mayu Inaba
title	Merlin is required for coordinating proliferation of two stem cell lineages in the Drosophila testis
title_short	Merlin is required for coordinating proliferation of two stem cell lineages in the Drosophila testis
title_full	Merlin is required for coordinating proliferation of two stem cell lineages in the Drosophila testis
title_fullStr	Merlin is required for coordinating proliferation of two stem cell lineages in the Drosophila testis
title_full_unstemmed	Merlin is required for coordinating proliferation of two stem cell lineages in the Drosophila testis
title_sort	merlin is required for coordinating proliferation of two stem cell lineages in the drosophila testis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ae374bcc28e84f61a919fe475de156c8
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Merlin is required for coordinating proliferation of two stem cell lineages in the Drosophila testis

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