Insulin resistance and inflammation markers in myocardial infarction

Olga Gruzdeva, Evgenya Uchasova, Yulia Dyleva, Ekaterina Belik, Ekaterina Shurygina, Olga BarbarashResearch Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, RussiaBackground: Insulin resistance (IR) is known to be characteristic of type 2 diabetes mellitus, and is regarded as an im...

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Autores principales:	Gruzdeva O, Uchasova E, Dyleva Y, Belik E, Shurygina E, Barbarash O
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/ae389acc2a2b495d972388ee049547d1
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spelling	oai:doaj.org-article:ae389acc2a2b495d972388ee049547d12021-12-02T05:13:14ZInsulin resistance and inflammation markers in myocardial infarction1178-7031https://doaj.org/article/ae389acc2a2b495d972388ee049547d12013-06-01T00:00:00Zhttp://www.dovepress.com/insulin-resistance-and-inflammation-markers-in-myocardial-infarction-a13383https://doaj.org/toc/1178-7031Olga Gruzdeva, Evgenya Uchasova, Yulia Dyleva, Ekaterina Belik, Ekaterina Shurygina, Olga BarbarashResearch Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, RussiaBackground: Insulin resistance (IR) is known to be characteristic of type 2 diabetes mellitus, and is regarded as an important mechanism in disease pathogenesis. One of the key pathogenetic mechanisms of IR progression is impaired free fatty acid (FFA) metabolism. Plasminogen-activator inhibitor 1 (PAI-1) and key inflammation markers, ie, interleukin 6 (IL-6) and C-reactive protein (CRP), also play a role.Purpose: To assess the changing levels of the metabolic proinflammation IR markers IL-6, CRP and PAI-1 and their association with the presence or absence of type 2 diabetes mellitus in myocardial infarction (MI) patients during their hospital stay.Methods: The patients were divided into two groups: group 1 included 95 nondiabetic MI patients, and group 2 enrolled 40 diabetic MI patients. The control group consisted of 30 sex- and age-matched volunteers. Serum IL-6 and CRP levels as well as FFA, glucose, C-peptide, insulin, and plasma PAI-1 concentrations were measured at days 1 and 12 from MI onset.Results: At day 1, there was an increase in glucose concentrations, which remained high in both groups by day 12 but was much higher in the diabetic patients. Basal insulin and C-peptide levels did not differ significantly from those in the control group. The quantitative insulin sensitivity-check index in both groups was significantly different from that in controls. FFA concentrations at day 1 in both diabetic and nondiabetic patients increased; by day 12, they had decreased but were still higher than the controls. CRP and IL-6 levels at day 1 were higher in all the patients, but diabetic patients had the highest levels; by day 12, the levels were lower but still 2.4-fold (IL-6) and 12.5-fold (CRP) higher than those in the control group.Conclusion: This study showed that MI is accompanied both by activated inflammatory response and IR. Strong correlations between IL-6 and FFA concentrations demonstrate that nonspecific inflammation factors are involved in IR development in MI patients. Consequently, these inflammatory cytokines might cause the development of IR.Keywords: insulin resistance, myocardial infarction, inflammation, type 2 diabetes mellitusGruzdeva OUchasova EDyleva YBelik EShurygina EBarbarash ODove Medical PressarticlePathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol 2013, Iss default, Pp 83-90 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Gruzdeva O Uchasova E Dyleva Y Belik E Shurygina E Barbarash O Insulin resistance and inflammation markers in myocardial infarction
description	Olga Gruzdeva, Evgenya Uchasova, Yulia Dyleva, Ekaterina Belik, Ekaterina Shurygina, Olga BarbarashResearch Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, RussiaBackground: Insulin resistance (IR) is known to be characteristic of type 2 diabetes mellitus, and is regarded as an important mechanism in disease pathogenesis. One of the key pathogenetic mechanisms of IR progression is impaired free fatty acid (FFA) metabolism. Plasminogen-activator inhibitor 1 (PAI-1) and key inflammation markers, ie, interleukin 6 (IL-6) and C-reactive protein (CRP), also play a role.Purpose: To assess the changing levels of the metabolic proinflammation IR markers IL-6, CRP and PAI-1 and their association with the presence or absence of type 2 diabetes mellitus in myocardial infarction (MI) patients during their hospital stay.Methods: The patients were divided into two groups: group 1 included 95 nondiabetic MI patients, and group 2 enrolled 40 diabetic MI patients. The control group consisted of 30 sex- and age-matched volunteers. Serum IL-6 and CRP levels as well as FFA, glucose, C-peptide, insulin, and plasma PAI-1 concentrations were measured at days 1 and 12 from MI onset.Results: At day 1, there was an increase in glucose concentrations, which remained high in both groups by day 12 but was much higher in the diabetic patients. Basal insulin and C-peptide levels did not differ significantly from those in the control group. The quantitative insulin sensitivity-check index in both groups was significantly different from that in controls. FFA concentrations at day 1 in both diabetic and nondiabetic patients increased; by day 12, they had decreased but were still higher than the controls. CRP and IL-6 levels at day 1 were higher in all the patients, but diabetic patients had the highest levels; by day 12, the levels were lower but still 2.4-fold (IL-6) and 12.5-fold (CRP) higher than those in the control group.Conclusion: This study showed that MI is accompanied both by activated inflammatory response and IR. Strong correlations between IL-6 and FFA concentrations demonstrate that nonspecific inflammation factors are involved in IR development in MI patients. Consequently, these inflammatory cytokines might cause the development of IR.Keywords: insulin resistance, myocardial infarction, inflammation, type 2 diabetes mellitus
format	article
author	Gruzdeva O Uchasova E Dyleva Y Belik E Shurygina E Barbarash O
author_facet	Gruzdeva O Uchasova E Dyleva Y Belik E Shurygina E Barbarash O
author_sort	Gruzdeva O
title	Insulin resistance and inflammation markers in myocardial infarction
title_short	Insulin resistance and inflammation markers in myocardial infarction
title_full	Insulin resistance and inflammation markers in myocardial infarction
title_fullStr	Insulin resistance and inflammation markers in myocardial infarction
title_full_unstemmed	Insulin resistance and inflammation markers in myocardial infarction
title_sort	insulin resistance and inflammation markers in myocardial infarction
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/ae389acc2a2b495d972388ee049547d1
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Insulin resistance and inflammation markers in myocardial infarction

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