Reciprocal regulation of RIG-I and XRCC4 connects DNA repair with RIG-I immune signaling

The RNA-sensing pathway has been associated with type I interferon (IFN) production induced by DNA damaging agents. Here the authors reveal that RIG-I, a cytosolic RNA sensor that recognizes RNA virus and initiates IFN signaling, is recruited to double-stranded breaks and suppresses non-homologous e...

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Autores principales:	Guijie Guo, Ming Gao, Xiaochen Gao, Bibo Zhu, Jinzhou Huang, Xinyi Tu, Wootae Kim, Fei Zhao, Qin Zhou, Shouhai Zhu, Zheming Wu, Yuanliang Yan, Yong Zhang, Xiangyu Zeng, Qian Zhu, Ping Yin, Kuntian Luo, Jie Sun, Min Deng, Zhenkun Lou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ae3a4b9c07f84e10aa3bce3333dfaaeb
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spelling	oai:doaj.org-article:ae3a4b9c07f84e10aa3bce3333dfaaeb2021-12-02T15:51:06ZReciprocal regulation of RIG-I and XRCC4 connects DNA repair with RIG-I immune signaling10.1038/s41467-021-22484-72041-1723https://doaj.org/article/ae3a4b9c07f84e10aa3bce3333dfaaeb2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22484-7https://doaj.org/toc/2041-1723The RNA-sensing pathway has been associated with type I interferon (IFN) production induced by DNA damaging agents. Here the authors reveal that RIG-I, a cytosolic RNA sensor that recognizes RNA virus and initiates IFN signaling, is recruited to double-stranded breaks and suppresses non-homologous end joining.Guijie GuoMing GaoXiaochen GaoBibo ZhuJinzhou HuangXinyi TuWootae KimFei ZhaoQin ZhouShouhai ZhuZheming WuYuanliang YanYong ZhangXiangyu ZengQian ZhuPing YinKuntian LuoJie SunMin DengZhenkun LouNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Guijie Guo Ming Gao Xiaochen Gao Bibo Zhu Jinzhou Huang Xinyi Tu Wootae Kim Fei Zhao Qin Zhou Shouhai Zhu Zheming Wu Yuanliang Yan Yong Zhang Xiangyu Zeng Qian Zhu Ping Yin Kuntian Luo Jie Sun Min Deng Zhenkun Lou Reciprocal regulation of RIG-I and XRCC4 connects DNA repair with RIG-I immune signaling
description	The RNA-sensing pathway has been associated with type I interferon (IFN) production induced by DNA damaging agents. Here the authors reveal that RIG-I, a cytosolic RNA sensor that recognizes RNA virus and initiates IFN signaling, is recruited to double-stranded breaks and suppresses non-homologous end joining.
format	article
author	Guijie Guo Ming Gao Xiaochen Gao Bibo Zhu Jinzhou Huang Xinyi Tu Wootae Kim Fei Zhao Qin Zhou Shouhai Zhu Zheming Wu Yuanliang Yan Yong Zhang Xiangyu Zeng Qian Zhu Ping Yin Kuntian Luo Jie Sun Min Deng Zhenkun Lou
author_facet	Guijie Guo Ming Gao Xiaochen Gao Bibo Zhu Jinzhou Huang Xinyi Tu Wootae Kim Fei Zhao Qin Zhou Shouhai Zhu Zheming Wu Yuanliang Yan Yong Zhang Xiangyu Zeng Qian Zhu Ping Yin Kuntian Luo Jie Sun Min Deng Zhenkun Lou
author_sort	Guijie Guo
title	Reciprocal regulation of RIG-I and XRCC4 connects DNA repair with RIG-I immune signaling
title_short	Reciprocal regulation of RIG-I and XRCC4 connects DNA repair with RIG-I immune signaling
title_full	Reciprocal regulation of RIG-I and XRCC4 connects DNA repair with RIG-I immune signaling
title_fullStr	Reciprocal regulation of RIG-I and XRCC4 connects DNA repair with RIG-I immune signaling
title_full_unstemmed	Reciprocal regulation of RIG-I and XRCC4 connects DNA repair with RIG-I immune signaling
title_sort	reciprocal regulation of rig-i and xrcc4 connects dna repair with rig-i immune signaling
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ae3a4b9c07f84e10aa3bce3333dfaaeb
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Reciprocal regulation of RIG-I and XRCC4 connects DNA repair with RIG-I immune signaling

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