Arp2/3 complex controls T cell homeostasis by maintaining surface TCR levels via regulating TCR+ endosome trafficking

Abstract T cell receptor (TCR) signaling is important for T cell homeostasis and function. However, how surface TCR levels are regulated and its biological significance on T cells remains largely unknown. Here, we show that the T cell-specific deletion of Arpc2, a component of Arp2/3 complex, result...

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Autores principales: Ye Zhang, Hao Shen, Haifeng Liu, Haiyun Feng, Yan Liu, Xiaoyan Zhu, Xiaolong Liu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/ae3bc8bd6ab84d138b7f827da4167c83
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