The Ketogenic Effect of Medium-Chain Triacylglycerides

Medium-chain triacylglycerides (MCTs) are dietary supplements that can induce ketosis without the need for a traditional ketogenic diet or prolonged fasting. They have the potential to marginally delay the progression of neurodegenerative diseases, such as Alzheimer's disease. However, there ha...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ting-Yu Lin, Hung-Wen Liu, Tsung-Min Hung
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	aging - old age - seniors cognition octanoic acid (caprylic acid) (PubChem CID: 379) decanoic acid (PubChem CID 2969) Tricaprin – Captex® 1000 (PubChem CID: 69310) Tricaprylin – Captex® 8000 (PubChem CID: 10850) Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/ae3dad9719b84c94b4b10e06f176bb57
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ae3dad9719b84c94b4b10e06f176bb57
record_format	dspace
spelling	oai:doaj.org-article:ae3dad9719b84c94b4b10e06f176bb572021-11-30T14:34:46ZThe Ketogenic Effect of Medium-Chain Triacylglycerides2296-861X10.3389/fnut.2021.747284https://doaj.org/article/ae3dad9719b84c94b4b10e06f176bb572021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnut.2021.747284/fullhttps://doaj.org/toc/2296-861XMedium-chain triacylglycerides (MCTs) are dietary supplements that can induce ketosis without the need for a traditional ketogenic diet or prolonged fasting. They have the potential to marginally delay the progression of neurodegenerative diseases, such as Alzheimer's disease. However, there have been inconsistencies in reports of the MCT dose–response relationship, which may be due to differences in MCT composition, participant characteristics, and other factors that can influence ketone generation. To resolve these discrepancies, we reviewed studies that investigated the ketogenic effect of MCTs in healthy adults. Aside from the treatment dose, other factors that can influence the ketogenic response, such as accompanying meals, fasting duration, and caffeine intake, were assessed. Based on the available literature, four practical recommendations are made to optimize the ketogenic effect of MCTs and reduce unwanted side effects (primarily gastrointestinal discomfort and diarrhea). First, the starting dose should be either 5 g of octanoic acid [caprylic acid (C8); a component of MCTs] or 5 g of a combination of C8 and decanoic or capric acid (C10; another component of MCTs), and the dose should be progressively increased to 15–20 g of C8. Second, MCTs should be consumed after an overnight fast, without an accompanying meal if tolerable, or with a low-carbohydrate meal. Third, the addition of caffeine may slightly increase the ketogenic response. Fourth, emulsifying the MCTs might increase their ketogenic effect and alleviate side effects.Ting-Yu LinHung-Wen LiuTsung-Min HungFrontiers Media S.A.articleaging - old age - seniorscognitionoctanoic acid (caprylic acid) (PubChem CID: 379)decanoic acid (PubChem CID 2969)Tricaprin – Captex® 1000 (PubChem CID: 69310)Tricaprylin – Captex® 8000 (PubChem CID: 10850)Nutrition. Foods and food supplyTX341-641ENFrontiers in Nutrition, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	aging - old age - seniors cognition octanoic acid (caprylic acid) (PubChem CID: 379) decanoic acid (PubChem CID 2969) Tricaprin – Captex® 1000 (PubChem CID: 69310) Tricaprylin – Captex® 8000 (PubChem CID: 10850) Nutrition. Foods and food supply TX341-641
spellingShingle	aging - old age - seniors cognition octanoic acid (caprylic acid) (PubChem CID: 379) decanoic acid (PubChem CID 2969) Tricaprin – Captex® 1000 (PubChem CID: 69310) Tricaprylin – Captex® 8000 (PubChem CID: 10850) Nutrition. Foods and food supply TX341-641 Ting-Yu Lin Hung-Wen Liu Tsung-Min Hung The Ketogenic Effect of Medium-Chain Triacylglycerides
description	Medium-chain triacylglycerides (MCTs) are dietary supplements that can induce ketosis without the need for a traditional ketogenic diet or prolonged fasting. They have the potential to marginally delay the progression of neurodegenerative diseases, such as Alzheimer's disease. However, there have been inconsistencies in reports of the MCT dose–response relationship, which may be due to differences in MCT composition, participant characteristics, and other factors that can influence ketone generation. To resolve these discrepancies, we reviewed studies that investigated the ketogenic effect of MCTs in healthy adults. Aside from the treatment dose, other factors that can influence the ketogenic response, such as accompanying meals, fasting duration, and caffeine intake, were assessed. Based on the available literature, four practical recommendations are made to optimize the ketogenic effect of MCTs and reduce unwanted side effects (primarily gastrointestinal discomfort and diarrhea). First, the starting dose should be either 5 g of octanoic acid [caprylic acid (C8); a component of MCTs] or 5 g of a combination of C8 and decanoic or capric acid (C10; another component of MCTs), and the dose should be progressively increased to 15–20 g of C8. Second, MCTs should be consumed after an overnight fast, without an accompanying meal if tolerable, or with a low-carbohydrate meal. Third, the addition of caffeine may slightly increase the ketogenic response. Fourth, emulsifying the MCTs might increase their ketogenic effect and alleviate side effects.
format	article
author	Ting-Yu Lin Hung-Wen Liu Tsung-Min Hung
author_facet	Ting-Yu Lin Hung-Wen Liu Tsung-Min Hung
author_sort	Ting-Yu Lin
title	The Ketogenic Effect of Medium-Chain Triacylglycerides
title_short	The Ketogenic Effect of Medium-Chain Triacylglycerides
title_full	The Ketogenic Effect of Medium-Chain Triacylglycerides
title_fullStr	The Ketogenic Effect of Medium-Chain Triacylglycerides
title_full_unstemmed	The Ketogenic Effect of Medium-Chain Triacylglycerides
title_sort	ketogenic effect of medium-chain triacylglycerides
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/ae3dad9719b84c94b4b10e06f176bb57
work_keys_str_mv	AT tingyulin theketogeniceffectofmediumchaintriacylglycerides AT hungwenliu theketogeniceffectofmediumchaintriacylglycerides AT tsungminhung theketogeniceffectofmediumchaintriacylglycerides AT tingyulin ketogeniceffectofmediumchaintriacylglycerides AT hungwenliu ketogeniceffectofmediumchaintriacylglycerides AT tsungminhung ketogeniceffectofmediumchaintriacylglycerides
_version_	1718406524259270656

The Ketogenic Effect of Medium-Chain Triacylglycerides

Ejemplares similares