Innate Immune Mechanisms and Immunotherapy of Myeloid Malignancies

Similar to other cancers, myeloid malignancies are thought to subvert the immune system during their development. This subversion occurs via both malignant cell-autonomous and non-autonomous mechanisms and involves manipulation of the innate and adaptive immune systems. Multiple strategies are being...

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Auteurs principaux:	Sara Small, Yazan Numan, Leonidas C. Platanias
Format:	article
Langue:	EN
Publié:	MDPI AG 2021
Sujets:	immunotherapy AML interferon antibodies myeloid malignancies CAR-T Biology (General) QH301-705.5
Accès en ligne:	https://doaj.org/article/ae3df64a813045f1920fbc5ebf226af4
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id	oai:doaj.org-article:ae3df64a813045f1920fbc5ebf226af4
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spelling	oai:doaj.org-article:ae3df64a813045f1920fbc5ebf226af42021-11-25T16:49:49ZInnate Immune Mechanisms and Immunotherapy of Myeloid Malignancies10.3390/biomedicines91116312227-9059https://doaj.org/article/ae3df64a813045f1920fbc5ebf226af42021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1631https://doaj.org/toc/2227-9059Similar to other cancers, myeloid malignancies are thought to subvert the immune system during their development. This subversion occurs via both malignant cell-autonomous and non-autonomous mechanisms and involves manipulation of the innate and adaptive immune systems. Multiple strategies are being studied to rejuvenate, redirect, or re-enforce the immune system in order to fight off myeloid malignancies. So far, the most successful strategies include interferon treatment and antibody-based therapies, though chimeric antigen receptor (CAR) cells and immune checkpoint inhibitors are also promising therapies. In this review, we discuss the inherent immune mechanisms of defense against myeloid malignancies, currently-approved agents, and agents under investigation. Overall, we evaluate the efficacy and potential of immuno-oncology in the treatment of myeloid malignancies.Sara SmallYazan NumanLeonidas C. PlataniasMDPI AGarticleimmunotherapyAMLinterferonantibodiesmyeloid malignanciesCAR-TBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1631, p 1631 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	immunotherapy AML interferon antibodies myeloid malignancies CAR-T Biology (General) QH301-705.5
spellingShingle	immunotherapy AML interferon antibodies myeloid malignancies CAR-T Biology (General) QH301-705.5 Sara Small Yazan Numan Leonidas C. Platanias Innate Immune Mechanisms and Immunotherapy of Myeloid Malignancies
description	Similar to other cancers, myeloid malignancies are thought to subvert the immune system during their development. This subversion occurs via both malignant cell-autonomous and non-autonomous mechanisms and involves manipulation of the innate and adaptive immune systems. Multiple strategies are being studied to rejuvenate, redirect, or re-enforce the immune system in order to fight off myeloid malignancies. So far, the most successful strategies include interferon treatment and antibody-based therapies, though chimeric antigen receptor (CAR) cells and immune checkpoint inhibitors are also promising therapies. In this review, we discuss the inherent immune mechanisms of defense against myeloid malignancies, currently-approved agents, and agents under investigation. Overall, we evaluate the efficacy and potential of immuno-oncology in the treatment of myeloid malignancies.
format	article
author	Sara Small Yazan Numan Leonidas C. Platanias
author_facet	Sara Small Yazan Numan Leonidas C. Platanias
author_sort	Sara Small
title	Innate Immune Mechanisms and Immunotherapy of Myeloid Malignancies
title_short	Innate Immune Mechanisms and Immunotherapy of Myeloid Malignancies
title_full	Innate Immune Mechanisms and Immunotherapy of Myeloid Malignancies
title_fullStr	Innate Immune Mechanisms and Immunotherapy of Myeloid Malignancies
title_full_unstemmed	Innate Immune Mechanisms and Immunotherapy of Myeloid Malignancies
title_sort	innate immune mechanisms and immunotherapy of myeloid malignancies
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ae3df64a813045f1920fbc5ebf226af4
work_keys_str_mv	AT sarasmall innateimmunemechanismsandimmunotherapyofmyeloidmalignancies AT yazannuman innateimmunemechanismsandimmunotherapyofmyeloidmalignancies AT leonidascplatanias innateimmunemechanismsandimmunotherapyofmyeloidmalignancies
_version_	1718412915984302080

Innate Immune Mechanisms and Immunotherapy of Myeloid Malignancies

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