Evolution of core archetypal phenotypes in progressive high grade serous ovarian cancer

Evolution of core archetypal phenotypes in progressive high grade serous ovarian cancer

High-grade serous ovarian cancer (HGSOC) is prone to developing resistance to treatment. Here, the authors use single-cell RNA-seq and an analysis of archetypes, and find that shifts in metabolism and proliferation are associated with the response to treatment and clonal heterogeneity in HGSOC.

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Detalles Bibliográficos
Autores principales: Aritro Nath, Patrick A. Cosgrove, Hoda Mirsafian, Elizabeth L. Christie, Lance Pflieger, Benjamin Copeland, Sumana Majumdar, Mihaela C. Cristea, Ernest S. Han, Stephen J. Lee, Edward W. Wang, Sian Fereday, Nadia Traficante, Ravi Salgia, Theresa Werner, Adam L. Cohen, Philip Moos, Jeffrey T. Chang, David D. L. Bowtell, Andrea H. Bild
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/ae3e02320d4947c59945469a2cf43f04
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Sumario:High-grade serous ovarian cancer (HGSOC) is prone to developing resistance to treatment. Here, the authors use single-cell RNA-seq and an analysis of archetypes, and find that shifts in metabolism and proliferation are associated with the response to treatment and clonal heterogeneity in HGSOC.

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