Evolution of core archetypal phenotypes in progressive high grade serous ovarian cancer
High-grade serous ovarian cancer (HGSOC) is prone to developing resistance to treatment. Here, the authors use single-cell RNA-seq and an analysis of archetypes, and find that shifts in metabolism and proliferation are associated with the response to treatment and clonal heterogeneity in HGSOC.
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Nature Portfolio
2021
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oai:doaj.org-article:ae3e02320d4947c59945469a2cf43f042021-12-02T14:42:18ZEvolution of core archetypal phenotypes in progressive high grade serous ovarian cancer10.1038/s41467-021-23171-32041-1723https://doaj.org/article/ae3e02320d4947c59945469a2cf43f042021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23171-3https://doaj.org/toc/2041-1723High-grade serous ovarian cancer (HGSOC) is prone to developing resistance to treatment. Here, the authors use single-cell RNA-seq and an analysis of archetypes, and find that shifts in metabolism and proliferation are associated with the response to treatment and clonal heterogeneity in HGSOC.Aritro NathPatrick A. CosgroveHoda MirsafianElizabeth L. ChristieLance PfliegerBenjamin CopelandSumana MajumdarMihaela C. CristeaErnest S. HanStephen J. LeeEdward W. WangSian FeredayNadia TraficanteRavi SalgiaTheresa WernerAdam L. CohenPhilip MoosJeffrey T. ChangDavid D. L. BowtellAndrea H. BildNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Aritro Nath Patrick A. Cosgrove Hoda Mirsafian Elizabeth L. Christie Lance Pflieger Benjamin Copeland Sumana Majumdar Mihaela C. Cristea Ernest S. Han Stephen J. Lee Edward W. Wang Sian Fereday Nadia Traficante Ravi Salgia Theresa Werner Adam L. Cohen Philip Moos Jeffrey T. Chang David D. L. Bowtell Andrea H. Bild Evolution of core archetypal phenotypes in progressive high grade serous ovarian cancer |
| description |
High-grade serous ovarian cancer (HGSOC) is prone to developing resistance to treatment. Here, the authors use single-cell RNA-seq and an analysis of archetypes, and find that shifts in metabolism and proliferation are associated with the response to treatment and clonal heterogeneity in HGSOC. |
| format |
article |
| author |
Aritro Nath Patrick A. Cosgrove Hoda Mirsafian Elizabeth L. Christie Lance Pflieger Benjamin Copeland Sumana Majumdar Mihaela C. Cristea Ernest S. Han Stephen J. Lee Edward W. Wang Sian Fereday Nadia Traficante Ravi Salgia Theresa Werner Adam L. Cohen Philip Moos Jeffrey T. Chang David D. L. Bowtell Andrea H. Bild |
| author_facet |
Aritro Nath Patrick A. Cosgrove Hoda Mirsafian Elizabeth L. Christie Lance Pflieger Benjamin Copeland Sumana Majumdar Mihaela C. Cristea Ernest S. Han Stephen J. Lee Edward W. Wang Sian Fereday Nadia Traficante Ravi Salgia Theresa Werner Adam L. Cohen Philip Moos Jeffrey T. Chang David D. L. Bowtell Andrea H. Bild |
| author_sort |
Aritro Nath |
| title |
Evolution of core archetypal phenotypes in progressive high grade serous ovarian cancer |
| title_short |
Evolution of core archetypal phenotypes in progressive high grade serous ovarian cancer |
| title_full |
Evolution of core archetypal phenotypes in progressive high grade serous ovarian cancer |
| title_fullStr |
Evolution of core archetypal phenotypes in progressive high grade serous ovarian cancer |
| title_full_unstemmed |
Evolution of core archetypal phenotypes in progressive high grade serous ovarian cancer |
| title_sort |
evolution of core archetypal phenotypes in progressive high grade serous ovarian cancer |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/ae3e02320d4947c59945469a2cf43f04 |
| work_keys_str_mv |
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1718389771597774848 |