The Role of Nutritional Lifestyle and Physical Activity in Multiple Sclerosis Pathogenesis and Management: A Narrative Review

Studies on the role of nutritional factors and physical activity (PA) in the pathogenesis of multiple sclerosis (MS) go back a long time. Despite the intrinsic difficulty of studying their positive or negative role in MS, the interest of researchers on these topics increased during the last few deca...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Salvatore Fanara, Maria Aprile, Salvatore Iacono, Giuseppe Schirò, Alessia Bianchi, Filippo Brighina, Ligia Juliana Dominguez, Paolo Ragonese, Giuseppe Salemi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	multiple sclerosis nutritional lifestyles physical activity low carbohydrate diet Mediterranean diet fasting-mimicking diet Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/ae41f58e7bfc407db642830d35c5cbb2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ae41f58e7bfc407db642830d35c5cbb2
record_format	dspace
spelling	oai:doaj.org-article:ae41f58e7bfc407db642830d35c5cbb22021-11-25T18:33:57ZThe Role of Nutritional Lifestyle and Physical Activity in Multiple Sclerosis Pathogenesis and Management: A Narrative Review10.3390/nu131137742072-6643https://doaj.org/article/ae41f58e7bfc407db642830d35c5cbb22021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3774https://doaj.org/toc/2072-6643Studies on the role of nutritional factors and physical activity (PA) in the pathogenesis of multiple sclerosis (MS) go back a long time. Despite the intrinsic difficulty of studying their positive or negative role in MS, the interest of researchers on these topics increased during the last few decades, since the role of diet has been investigated with the perspective of the association with disease-modifying drugs (DMD). The association of DMD, diets, and PA might have an additive effect in modifying disease severity. Among the various diets investigated (low-carbohydrate, gluten-free, Mediterranean, low-fat, fasting-mimicking, and Western diets) only low-carbohydrate, Mediterranean, and fast-mimicking diets have shown both in animal models and in humans a positive effect on MS course and in patient-reported outcomes (PROs). However, the Mediterranean diet is easier to be maintained compared to fast-mimicking and low-carbohydrate diets, which may lead to detrimental side effects requiring careful clinical monitoring. Conversely, the Western diet, which is characterized by a high intake of highly saturated fats and carbohydrates, may lead to the activation of pro-inflammatory immune pathways and is therefore not recommended. PA showed a positive effect both in animal models as well as on disease course and PROs in humans. Training with combined exercises is considered the more effective approach.Salvatore FanaraMaria AprileSalvatore IaconoGiuseppe SchiròAlessia BianchiFilippo BrighinaLigia Juliana DominguezPaolo RagoneseGiuseppe SalemiMDPI AGarticlemultiple sclerosisnutritional lifestylesphysical activitylow carbohydrate dietMediterranean dietfasting-mimicking dietNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3774, p 3774 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	multiple sclerosis nutritional lifestyles physical activity low carbohydrate diet Mediterranean diet fasting-mimicking diet Nutrition. Foods and food supply TX341-641
spellingShingle	multiple sclerosis nutritional lifestyles physical activity low carbohydrate diet Mediterranean diet fasting-mimicking diet Nutrition. Foods and food supply TX341-641 Salvatore Fanara Maria Aprile Salvatore Iacono Giuseppe Schirò Alessia Bianchi Filippo Brighina Ligia Juliana Dominguez Paolo Ragonese Giuseppe Salemi The Role of Nutritional Lifestyle and Physical Activity in Multiple Sclerosis Pathogenesis and Management: A Narrative Review
description	Studies on the role of nutritional factors and physical activity (PA) in the pathogenesis of multiple sclerosis (MS) go back a long time. Despite the intrinsic difficulty of studying their positive or negative role in MS, the interest of researchers on these topics increased during the last few decades, since the role of diet has been investigated with the perspective of the association with disease-modifying drugs (DMD). The association of DMD, diets, and PA might have an additive effect in modifying disease severity. Among the various diets investigated (low-carbohydrate, gluten-free, Mediterranean, low-fat, fasting-mimicking, and Western diets) only low-carbohydrate, Mediterranean, and fast-mimicking diets have shown both in animal models and in humans a positive effect on MS course and in patient-reported outcomes (PROs). However, the Mediterranean diet is easier to be maintained compared to fast-mimicking and low-carbohydrate diets, which may lead to detrimental side effects requiring careful clinical monitoring. Conversely, the Western diet, which is characterized by a high intake of highly saturated fats and carbohydrates, may lead to the activation of pro-inflammatory immune pathways and is therefore not recommended. PA showed a positive effect both in animal models as well as on disease course and PROs in humans. Training with combined exercises is considered the more effective approach.
format	article
author	Salvatore Fanara Maria Aprile Salvatore Iacono Giuseppe Schirò Alessia Bianchi Filippo Brighina Ligia Juliana Dominguez Paolo Ragonese Giuseppe Salemi
author_facet	Salvatore Fanara Maria Aprile Salvatore Iacono Giuseppe Schirò Alessia Bianchi Filippo Brighina Ligia Juliana Dominguez Paolo Ragonese Giuseppe Salemi
author_sort	Salvatore Fanara
title	The Role of Nutritional Lifestyle and Physical Activity in Multiple Sclerosis Pathogenesis and Management: A Narrative Review
title_short	The Role of Nutritional Lifestyle and Physical Activity in Multiple Sclerosis Pathogenesis and Management: A Narrative Review
title_full	The Role of Nutritional Lifestyle and Physical Activity in Multiple Sclerosis Pathogenesis and Management: A Narrative Review
title_fullStr	The Role of Nutritional Lifestyle and Physical Activity in Multiple Sclerosis Pathogenesis and Management: A Narrative Review
title_full_unstemmed	The Role of Nutritional Lifestyle and Physical Activity in Multiple Sclerosis Pathogenesis and Management: A Narrative Review
title_sort	role of nutritional lifestyle and physical activity in multiple sclerosis pathogenesis and management: a narrative review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ae41f58e7bfc407db642830d35c5cbb2
work_keys_str_mv	AT salvatorefanara theroleofnutritionallifestyleandphysicalactivityinmultiplesclerosispathogenesisandmanagementanarrativereview AT mariaaprile theroleofnutritionallifestyleandphysicalactivityinmultiplesclerosispathogenesisandmanagementanarrativereview AT salvatoreiacono theroleofnutritionallifestyleandphysicalactivityinmultiplesclerosispathogenesisandmanagementanarrativereview AT giuseppeschiro theroleofnutritionallifestyleandphysicalactivityinmultiplesclerosispathogenesisandmanagementanarrativereview AT alessiabianchi theroleofnutritionallifestyleandphysicalactivityinmultiplesclerosispathogenesisandmanagementanarrativereview AT filippobrighina theroleofnutritionallifestyleandphysicalactivityinmultiplesclerosispathogenesisandmanagementanarrativereview AT ligiajulianadominguez theroleofnutritionallifestyleandphysicalactivityinmultiplesclerosispathogenesisandmanagementanarrativereview AT paoloragonese theroleofnutritionallifestyleandphysicalactivityinmultiplesclerosispathogenesisandmanagementanarrativereview AT giuseppesalemi theroleofnutritionallifestyleandphysicalactivityinmultiplesclerosispathogenesisandmanagementanarrativereview AT salvatorefanara roleofnutritionallifestyleandphysicalactivityinmultiplesclerosispathogenesisandmanagementanarrativereview AT mariaaprile roleofnutritionallifestyleandphysicalactivityinmultiplesclerosispathogenesisandmanagementanarrativereview AT salvatoreiacono roleofnutritionallifestyleandphysicalactivityinmultiplesclerosispathogenesisandmanagementanarrativereview AT giuseppeschiro roleofnutritionallifestyleandphysicalactivityinmultiplesclerosispathogenesisandmanagementanarrativereview AT alessiabianchi roleofnutritionallifestyleandphysicalactivityinmultiplesclerosispathogenesisandmanagementanarrativereview AT filippobrighina roleofnutritionallifestyleandphysicalactivityinmultiplesclerosispathogenesisandmanagementanarrativereview AT ligiajulianadominguez roleofnutritionallifestyleandphysicalactivityinmultiplesclerosispathogenesisandmanagementanarrativereview AT paoloragonese roleofnutritionallifestyleandphysicalactivityinmultiplesclerosispathogenesisandmanagementanarrativereview AT giuseppesalemi roleofnutritionallifestyleandphysicalactivityinmultiplesclerosispathogenesisandmanagementanarrativereview
_version_	1718410971661205504

The Role of Nutritional Lifestyle and Physical Activity in Multiple Sclerosis Pathogenesis and Management: A Narrative Review

Ejemplares similares