Exosomal miRNAs and lncRNAs: The Modulator Keys of Cancer-Associated Fibroblasts in the Genesis and Progression of Malignant Neoplasms

The tumor microenvironment is made up of a universe of molecular and cellular components that promote or inhibit the development of neoplasms. Among the molecular elements are cytokines, metalloproteinases, proteins, mitochondrial DNA, and nucleic acids, within which the ncRNAs: miRNAs and lncRNAs s...

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Autores principales:	Julio César Villegas-Pineda, Mélida del Rosario Lizarazo-Taborda, Adrián Ramírez-de-Arellano, Ana Laura Pereira-Suárez
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	cancer cancer-associated fibroblast tumor microenvironment exosomes miRNAs lncRNAs Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/ae47ee944a094f97baa9c446910dabdd
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spelling	oai:doaj.org-article:ae47ee944a094f97baa9c446910dabdd2021-12-01T13:23:05ZExosomal miRNAs and lncRNAs: The Modulator Keys of Cancer-Associated Fibroblasts in the Genesis and Progression of Malignant Neoplasms2296-634X10.3389/fcell.2021.717478https://doaj.org/article/ae47ee944a094f97baa9c446910dabdd2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.717478/fullhttps://doaj.org/toc/2296-634XThe tumor microenvironment is made up of a universe of molecular and cellular components that promote or inhibit the development of neoplasms. Among the molecular elements are cytokines, metalloproteinases, proteins, mitochondrial DNA, and nucleic acids, within which the ncRNAs: miRNAs and lncRNAs stand out due to their direct modulating effects on the genesis and progression of various cancers. Regarding cellular elements, the solid tumor microenvironment is made up of tumor cells, healthy adjacent epithelial cells, immune system cells, endothelial cells, and stromal cells, such as cancer-associated fibroblasts, which are capable of generating a modulating communication network with the other components of the tumor microenvironment through, among other mechanisms, the secretion of exosomal vesicles loaded with miRNAs and lncRNAs. These ncRNAs are key pieces in developing neoplasms since they have diverse effects on cancer cells and healthy cells, favoring or negatively regulating protumoral cellular events, such as migration, invasion, proliferation, metastasis, epithelial-mesenchymal transition, and resistance to treatment. Due to the growing number of relevant evidence in recent years, this work focused on reviewing, analyzing, highlighting, and showing the current state of research on exosomal ncRNAs derived from cancer-associated fibroblasts and their effects on different neoplasms. A future perspective on using these ncRNAs as real therapeutic tools in the treatment of cancer patients is also proposed.Julio César Villegas-PinedaJulio César Villegas-PinedaMélida del Rosario Lizarazo-TabordaAdrián Ramírez-de-ArellanoAna Laura Pereira-SuárezAna Laura Pereira-SuárezFrontiers Media S.A.articlecancercancer-associated fibroblasttumor microenvironmentexosomesmiRNAslncRNAsBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cancer cancer-associated fibroblast tumor microenvironment exosomes miRNAs lncRNAs Biology (General) QH301-705.5
spellingShingle	cancer cancer-associated fibroblast tumor microenvironment exosomes miRNAs lncRNAs Biology (General) QH301-705.5 Julio César Villegas-Pineda Julio César Villegas-Pineda Mélida del Rosario Lizarazo-Taborda Adrián Ramírez-de-Arellano Ana Laura Pereira-Suárez Ana Laura Pereira-Suárez Exosomal miRNAs and lncRNAs: The Modulator Keys of Cancer-Associated Fibroblasts in the Genesis and Progression of Malignant Neoplasms
description	The tumor microenvironment is made up of a universe of molecular and cellular components that promote or inhibit the development of neoplasms. Among the molecular elements are cytokines, metalloproteinases, proteins, mitochondrial DNA, and nucleic acids, within which the ncRNAs: miRNAs and lncRNAs stand out due to their direct modulating effects on the genesis and progression of various cancers. Regarding cellular elements, the solid tumor microenvironment is made up of tumor cells, healthy adjacent epithelial cells, immune system cells, endothelial cells, and stromal cells, such as cancer-associated fibroblasts, which are capable of generating a modulating communication network with the other components of the tumor microenvironment through, among other mechanisms, the secretion of exosomal vesicles loaded with miRNAs and lncRNAs. These ncRNAs are key pieces in developing neoplasms since they have diverse effects on cancer cells and healthy cells, favoring or negatively regulating protumoral cellular events, such as migration, invasion, proliferation, metastasis, epithelial-mesenchymal transition, and resistance to treatment. Due to the growing number of relevant evidence in recent years, this work focused on reviewing, analyzing, highlighting, and showing the current state of research on exosomal ncRNAs derived from cancer-associated fibroblasts and their effects on different neoplasms. A future perspective on using these ncRNAs as real therapeutic tools in the treatment of cancer patients is also proposed.
format	article
author	Julio César Villegas-Pineda Julio César Villegas-Pineda Mélida del Rosario Lizarazo-Taborda Adrián Ramírez-de-Arellano Ana Laura Pereira-Suárez Ana Laura Pereira-Suárez
author_facet	Julio César Villegas-Pineda Julio César Villegas-Pineda Mélida del Rosario Lizarazo-Taborda Adrián Ramírez-de-Arellano Ana Laura Pereira-Suárez Ana Laura Pereira-Suárez
author_sort	Julio César Villegas-Pineda
title	Exosomal miRNAs and lncRNAs: The Modulator Keys of Cancer-Associated Fibroblasts in the Genesis and Progression of Malignant Neoplasms
title_short	Exosomal miRNAs and lncRNAs: The Modulator Keys of Cancer-Associated Fibroblasts in the Genesis and Progression of Malignant Neoplasms
title_full	Exosomal miRNAs and lncRNAs: The Modulator Keys of Cancer-Associated Fibroblasts in the Genesis and Progression of Malignant Neoplasms
title_fullStr	Exosomal miRNAs and lncRNAs: The Modulator Keys of Cancer-Associated Fibroblasts in the Genesis and Progression of Malignant Neoplasms
title_full_unstemmed	Exosomal miRNAs and lncRNAs: The Modulator Keys of Cancer-Associated Fibroblasts in the Genesis and Progression of Malignant Neoplasms
title_sort	exosomal mirnas and lncrnas: the modulator keys of cancer-associated fibroblasts in the genesis and progression of malignant neoplasms
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/ae47ee944a094f97baa9c446910dabdd
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Exosomal miRNAs and lncRNAs: The Modulator Keys of Cancer-Associated Fibroblasts in the Genesis and Progression of Malignant Neoplasms

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