Overexpression of neuregulin 1 in GABAergic interneurons results in reversible cortical disinhibition

The molecular and cellular mechanisms of cortical disinhibition as a common feature of many psychiatric diseases are not fully understood. The authors identify an interaction between NRG1 and Nav1.1 sodium channel as a mechanism of how NRG1 modulates the excitability of GABAergic interneurons.

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Autores principales:	Yao-Yi Wang, Bing Zhao, Meng-Meng Wu, Xiao-Li Zheng, Longnian Lin, Dong-Min Yin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ae47f44aa2ba4cdea249325f289d923d
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spelling	oai:doaj.org-article:ae47f44aa2ba4cdea249325f289d923d2021-12-02T15:22:39ZOverexpression of neuregulin 1 in GABAergic interneurons results in reversible cortical disinhibition10.1038/s41467-020-20552-y2041-1723https://doaj.org/article/ae47f44aa2ba4cdea249325f289d923d2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20552-yhttps://doaj.org/toc/2041-1723The molecular and cellular mechanisms of cortical disinhibition as a common feature of many psychiatric diseases are not fully understood. The authors identify an interaction between NRG1 and Nav1.1 sodium channel as a mechanism of how NRG1 modulates the excitability of GABAergic interneurons.Yao-Yi WangBing ZhaoMeng-Meng WuXiao-Li ZhengLongnian LinDong-Min YinNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yao-Yi Wang Bing Zhao Meng-Meng Wu Xiao-Li Zheng Longnian Lin Dong-Min Yin Overexpression of neuregulin 1 in GABAergic interneurons results in reversible cortical disinhibition
description	The molecular and cellular mechanisms of cortical disinhibition as a common feature of many psychiatric diseases are not fully understood. The authors identify an interaction between NRG1 and Nav1.1 sodium channel as a mechanism of how NRG1 modulates the excitability of GABAergic interneurons.
format	article
author	Yao-Yi Wang Bing Zhao Meng-Meng Wu Xiao-Li Zheng Longnian Lin Dong-Min Yin
author_facet	Yao-Yi Wang Bing Zhao Meng-Meng Wu Xiao-Li Zheng Longnian Lin Dong-Min Yin
author_sort	Yao-Yi Wang
title	Overexpression of neuregulin 1 in GABAergic interneurons results in reversible cortical disinhibition
title_short	Overexpression of neuregulin 1 in GABAergic interneurons results in reversible cortical disinhibition
title_full	Overexpression of neuregulin 1 in GABAergic interneurons results in reversible cortical disinhibition
title_fullStr	Overexpression of neuregulin 1 in GABAergic interneurons results in reversible cortical disinhibition
title_full_unstemmed	Overexpression of neuregulin 1 in GABAergic interneurons results in reversible cortical disinhibition
title_sort	overexpression of neuregulin 1 in gabaergic interneurons results in reversible cortical disinhibition
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ae47f44aa2ba4cdea249325f289d923d
work_keys_str_mv	AT yaoyiwang overexpressionofneuregulin1ingabaergicinterneuronsresultsinreversiblecorticaldisinhibition AT bingzhao overexpressionofneuregulin1ingabaergicinterneuronsresultsinreversiblecorticaldisinhibition AT mengmengwu overexpressionofneuregulin1ingabaergicinterneuronsresultsinreversiblecorticaldisinhibition AT xiaolizheng overexpressionofneuregulin1ingabaergicinterneuronsresultsinreversiblecorticaldisinhibition AT longnianlin overexpressionofneuregulin1ingabaergicinterneuronsresultsinreversiblecorticaldisinhibition AT dongminyin overexpressionofneuregulin1ingabaergicinterneuronsresultsinreversiblecorticaldisinhibition
_version_	1718387397845057536

Overexpression of neuregulin 1 in GABAergic interneurons results in reversible cortical disinhibition

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