Randomized, double-blind, placebo-controlled clinical trial measuring the effect of a dietetic food on dermatologic scoring and pruritus in dogs with atopic dermatitis

Abstract Background Canine atopic dermatitis (AD) is a common condition that often requires multimodal therapy. Including a diet in the multimodal management of AD may reduce medication doses, saving pet owners money and reducing side effects. The objective of this randomized, double-blind, placebo-...

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Autores principales:	Miguel Sánchez de Santiago, José Luis González Arribas, Yolanda Moral Llamas, Iveta Becvarova, Hein Meyer
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Canine Atopy Nutrition Allergy Dermatology Veterinary Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/ae47f6ef3f2349f799ebd9a843c88266
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spelling	oai:doaj.org-article:ae47f6ef3f2349f799ebd9a843c882662021-11-21T12:25:55ZRandomized, double-blind, placebo-controlled clinical trial measuring the effect of a dietetic food on dermatologic scoring and pruritus in dogs with atopic dermatitis10.1186/s12917-021-03063-w1746-6148https://doaj.org/article/ae47f6ef3f2349f799ebd9a843c882662021-11-01T00:00:00Zhttps://doi.org/10.1186/s12917-021-03063-whttps://doaj.org/toc/1746-6148Abstract Background Canine atopic dermatitis (AD) is a common condition that often requires multimodal therapy. Including a diet in the multimodal management of AD may reduce medication doses, saving pet owners money and reducing side effects. The objective of this randomized, double-blind, placebo-controlled clinical trial was to determine if a diet fortified in antioxidants, polyphenols, and omega-3 fatty acids can reduce the clinical signs of AD. Forty client-owned dogs with AD were enrolled in the study and assigned to either an enriched diet (diet B) or control diet (diet A) for 60-days. CADESI-4 index scores and owner-reported pruritus scores were measured periodically. Results Total CADESI-4 index scores for dogs eating diet B were lower on day 60 compared to baseline (P = 0.003). There was no statistical difference in scores for dogs eating diet A over a 60-day period. Diet B dogs had 25 and 49% reductions in CADESI-4 index scores on days 30 and 60, respectively (P = 0.0007) while diet A had no change over the study period. When comparing the percent change in owner-reported pruritus scores, diet B also performed better than diet A. By day 60, owners feeding diet B to their dogs reported a significant reduction (P < 0.0001) of 46.4% in itching, while those on diet A reported a 26.8% reduction, which was not statistically significant (P = 0.08). Conclusions These study results demonstrate feeding a diet enriched with ingredients to improve skin health and reduce inflammation improves the clinical signs of AD in dogs.Miguel Sánchez de SantiagoJosé Luis González ArribasYolanda Moral LlamasIveta BecvarovaHein MeyerBMCarticleCanineAtopyNutritionAllergyDermatologyVeterinaryVeterinary medicineSF600-1100ENBMC Veterinary Research, Vol 17, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Canine Atopy Nutrition Allergy Dermatology Veterinary Veterinary medicine SF600-1100
spellingShingle	Canine Atopy Nutrition Allergy Dermatology Veterinary Veterinary medicine SF600-1100 Miguel Sánchez de Santiago José Luis González Arribas Yolanda Moral Llamas Iveta Becvarova Hein Meyer Randomized, double-blind, placebo-controlled clinical trial measuring the effect of a dietetic food on dermatologic scoring and pruritus in dogs with atopic dermatitis
description	Abstract Background Canine atopic dermatitis (AD) is a common condition that often requires multimodal therapy. Including a diet in the multimodal management of AD may reduce medication doses, saving pet owners money and reducing side effects. The objective of this randomized, double-blind, placebo-controlled clinical trial was to determine if a diet fortified in antioxidants, polyphenols, and omega-3 fatty acids can reduce the clinical signs of AD. Forty client-owned dogs with AD were enrolled in the study and assigned to either an enriched diet (diet B) or control diet (diet A) for 60-days. CADESI-4 index scores and owner-reported pruritus scores were measured periodically. Results Total CADESI-4 index scores for dogs eating diet B were lower on day 60 compared to baseline (P = 0.003). There was no statistical difference in scores for dogs eating diet A over a 60-day period. Diet B dogs had 25 and 49% reductions in CADESI-4 index scores on days 30 and 60, respectively (P = 0.0007) while diet A had no change over the study period. When comparing the percent change in owner-reported pruritus scores, diet B also performed better than diet A. By day 60, owners feeding diet B to their dogs reported a significant reduction (P < 0.0001) of 46.4% in itching, while those on diet A reported a 26.8% reduction, which was not statistically significant (P = 0.08). Conclusions These study results demonstrate feeding a diet enriched with ingredients to improve skin health and reduce inflammation improves the clinical signs of AD in dogs.
format	article
author	Miguel Sánchez de Santiago José Luis González Arribas Yolanda Moral Llamas Iveta Becvarova Hein Meyer
author_facet	Miguel Sánchez de Santiago José Luis González Arribas Yolanda Moral Llamas Iveta Becvarova Hein Meyer
author_sort	Miguel Sánchez de Santiago
title	Randomized, double-blind, placebo-controlled clinical trial measuring the effect of a dietetic food on dermatologic scoring and pruritus in dogs with atopic dermatitis
title_short	Randomized, double-blind, placebo-controlled clinical trial measuring the effect of a dietetic food on dermatologic scoring and pruritus in dogs with atopic dermatitis
title_full	Randomized, double-blind, placebo-controlled clinical trial measuring the effect of a dietetic food on dermatologic scoring and pruritus in dogs with atopic dermatitis
title_fullStr	Randomized, double-blind, placebo-controlled clinical trial measuring the effect of a dietetic food on dermatologic scoring and pruritus in dogs with atopic dermatitis
title_full_unstemmed	Randomized, double-blind, placebo-controlled clinical trial measuring the effect of a dietetic food on dermatologic scoring and pruritus in dogs with atopic dermatitis
title_sort	randomized, double-blind, placebo-controlled clinical trial measuring the effect of a dietetic food on dermatologic scoring and pruritus in dogs with atopic dermatitis
publisher	BMC
publishDate	2021
url	https://doaj.org/article/ae47f6ef3f2349f799ebd9a843c88266
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Randomized, double-blind, placebo-controlled clinical trial measuring the effect of a dietetic food on dermatologic scoring and pruritus in dogs with atopic dermatitis

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