Decidualisation and placentation defects are a major cause of age-related reproductive decline

Advanced maternal age has been associated with lower reproductive success and higher risk of pregnancy complications. Here the authors show that maternal ageing-related embryonic abnormalities in mouse are caused by decidualisation and placentation defects that can be rescued by transferring the emb...

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Autores principales:	Laura Woods, Vicente Perez-Garcia, Jens Kieckbusch, Xiaoqiu Wang, Francesco DeMayo, Francesco Colucci, Myriam Hemberger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ae4829e2c1f4498cb0b96e9439f9ed86
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spelling	oai:doaj.org-article:ae4829e2c1f4498cb0b96e9439f9ed862021-12-02T14:41:19ZDecidualisation and placentation defects are a major cause of age-related reproductive decline10.1038/s41467-017-00308-x2041-1723https://doaj.org/article/ae4829e2c1f4498cb0b96e9439f9ed862017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00308-xhttps://doaj.org/toc/2041-1723Advanced maternal age has been associated with lower reproductive success and higher risk of pregnancy complications. Here the authors show that maternal ageing-related embryonic abnormalities in mouse are caused by decidualisation and placentation defects that can be rescued by transferring the embryo from an old to a young uterus.Laura WoodsVicente Perez-GarciaJens KieckbuschXiaoqiu WangFrancesco DeMayoFrancesco ColucciMyriam HembergerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Laura Woods Vicente Perez-Garcia Jens Kieckbusch Xiaoqiu Wang Francesco DeMayo Francesco Colucci Myriam Hemberger Decidualisation and placentation defects are a major cause of age-related reproductive decline
description	Advanced maternal age has been associated with lower reproductive success and higher risk of pregnancy complications. Here the authors show that maternal ageing-related embryonic abnormalities in mouse are caused by decidualisation and placentation defects that can be rescued by transferring the embryo from an old to a young uterus.
format	article
author	Laura Woods Vicente Perez-Garcia Jens Kieckbusch Xiaoqiu Wang Francesco DeMayo Francesco Colucci Myriam Hemberger
author_facet	Laura Woods Vicente Perez-Garcia Jens Kieckbusch Xiaoqiu Wang Francesco DeMayo Francesco Colucci Myriam Hemberger
author_sort	Laura Woods
title	Decidualisation and placentation defects are a major cause of age-related reproductive decline
title_short	Decidualisation and placentation defects are a major cause of age-related reproductive decline
title_full	Decidualisation and placentation defects are a major cause of age-related reproductive decline
title_fullStr	Decidualisation and placentation defects are a major cause of age-related reproductive decline
title_full_unstemmed	Decidualisation and placentation defects are a major cause of age-related reproductive decline
title_sort	decidualisation and placentation defects are a major cause of age-related reproductive decline
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ae4829e2c1f4498cb0b96e9439f9ed86
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Decidualisation and placentation defects are a major cause of age-related reproductive decline

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