Galectin-3 captures interferon-gamma in the tumor matrix reducing chemokine gradient production and T-cell tumor infiltration

Most tumours are poorly infiltrated by T cells. Here the authors show that galectin-3 secreted by tumours binds both glycosylated IFNγ and glycoproteins of the tumour extracellular matrix, thus avoiding IFNγ diffusion and the formation of an IFNγ-induced chemokine gradient required for T cell infilt...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Monica Gordon-Alonso, Thibault Hirsch, Claude Wildmann, Pierre van der Bruggen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ae4938525c0b414ebd58383ae6a1f724
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ae4938525c0b414ebd58383ae6a1f724
record_format	dspace
spelling	oai:doaj.org-article:ae4938525c0b414ebd58383ae6a1f7242021-12-02T14:42:39ZGalectin-3 captures interferon-gamma in the tumor matrix reducing chemokine gradient production and T-cell tumor infiltration10.1038/s41467-017-00925-62041-1723https://doaj.org/article/ae4938525c0b414ebd58383ae6a1f7242017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00925-6https://doaj.org/toc/2041-1723Most tumours are poorly infiltrated by T cells. Here the authors show that galectin-3 secreted by tumours binds both glycosylated IFNγ and glycoproteins of the tumour extracellular matrix, thus avoiding IFNγ diffusion and the formation of an IFNγ-induced chemokine gradient required for T cell infiltration.Monica Gordon-AlonsoThibault HirschClaude WildmannPierre van der BruggenNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Monica Gordon-Alonso Thibault Hirsch Claude Wildmann Pierre van der Bruggen Galectin-3 captures interferon-gamma in the tumor matrix reducing chemokine gradient production and T-cell tumor infiltration
description	Most tumours are poorly infiltrated by T cells. Here the authors show that galectin-3 secreted by tumours binds both glycosylated IFNγ and glycoproteins of the tumour extracellular matrix, thus avoiding IFNγ diffusion and the formation of an IFNγ-induced chemokine gradient required for T cell infiltration.
format	article
author	Monica Gordon-Alonso Thibault Hirsch Claude Wildmann Pierre van der Bruggen
author_facet	Monica Gordon-Alonso Thibault Hirsch Claude Wildmann Pierre van der Bruggen
author_sort	Monica Gordon-Alonso
title	Galectin-3 captures interferon-gamma in the tumor matrix reducing chemokine gradient production and T-cell tumor infiltration
title_short	Galectin-3 captures interferon-gamma in the tumor matrix reducing chemokine gradient production and T-cell tumor infiltration
title_full	Galectin-3 captures interferon-gamma in the tumor matrix reducing chemokine gradient production and T-cell tumor infiltration
title_fullStr	Galectin-3 captures interferon-gamma in the tumor matrix reducing chemokine gradient production and T-cell tumor infiltration
title_full_unstemmed	Galectin-3 captures interferon-gamma in the tumor matrix reducing chemokine gradient production and T-cell tumor infiltration
title_sort	galectin-3 captures interferon-gamma in the tumor matrix reducing chemokine gradient production and t-cell tumor infiltration
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ae4938525c0b414ebd58383ae6a1f724
work_keys_str_mv	AT monicagordonalonso galectin3capturesinterferongammainthetumormatrixreducingchemokinegradientproductionandtcelltumorinfiltration AT thibaulthirsch galectin3capturesinterferongammainthetumormatrixreducingchemokinegradientproductionandtcelltumorinfiltration AT claudewildmann galectin3capturesinterferongammainthetumormatrixreducingchemokinegradientproductionandtcelltumorinfiltration AT pierrevanderbruggen galectin3capturesinterferongammainthetumormatrixreducingchemokinegradientproductionandtcelltumorinfiltration
_version_	1718389652886388736

Galectin-3 captures interferon-gamma in the tumor matrix reducing chemokine gradient production and T-cell tumor infiltration

Ejemplares similares