Structure of immune dysfunctions in patients with chronic urogenital infections

In recent years, the growth of urogenital infections, often transforming into chronic forms, is one of the most common causes of reproductive damage in women. The aim of the research was to study the structure of immune dysfunctions in patients with chronic urogenital infection. A one-stage observat...

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Autores principales:	V. A. Kramarskiy, V. S. Gorin, A. I. Budaev, Y. V. Trusov
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2018
Materias:	inflammation infection genitals immunity immune deficiency Science Q
Acceso en línea:	https://doaj.org/article/ae49e7c9f4fc401a97a1316f8b8eb5e0
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spelling	oai:doaj.org-article:ae49e7c9f4fc401a97a1316f8b8eb5e02021-11-23T06:14:40ZStructure of immune dysfunctions in patients with chronic urogenital infections2541-94202587-959610.29413/ABS.2018-3.2.1https://doaj.org/article/ae49e7c9f4fc401a97a1316f8b8eb5e02018-04-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/551https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596In recent years, the growth of urogenital infections, often transforming into chronic forms, is one of the most common causes of reproductive damage in women. The aim of the research was to study the structure of immune dysfunctions in patients with chronic urogenital infection. A one-stage observational study of 80 women of reproductive age with chronic urogenital infections was carried out. The control group consisted of 40 healthy women-donors. The main outcome of the study was the severity of the immunocomprometry of the female. The contents of different subpopulations of lymphocytes (CD3+, CD4+ and CD8+ T-lymphocytes, CD20+ B-), phagocytic activity of granulocytes and monocytes were determined, the migration index, the migration inhibition index, and the exponential function were calculated. The complex of immune dysfunctions established in such patients included a decrease in the number of T-cells and, primarily, CD4+ lymphocytes and their low mitogenic reactivity, an increase in the proportion of natural killer cells, a decrease in the number of actively phagocytic neutrophils and monocytes, the last hydrogen peroxide, an increase in the production of IgA and IgG. Typical were combinations of these violations. Conclusions: T-lymphocyte-monocyte immune deficitiency with the activation of the humoral link and the defectiveness of phagocytosis is a distinctive characteristic of chronic urogenital infection.V. A. KramarskiyV. S. GorinA. I. BudaevY. V. TrusovScientific Сentre for Family Health and Human Reproduction Problemsarticleinflammationinfectiongenitalsimmunityimmune deficiencyScienceQRUActa Biomedica Scientifica, Vol 3, Iss 2, Pp 9-14 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	inflammation infection genitals immunity immune deficiency Science Q
spellingShingle	inflammation infection genitals immunity immune deficiency Science Q V. A. Kramarskiy V. S. Gorin A. I. Budaev Y. V. Trusov Structure of immune dysfunctions in patients with chronic urogenital infections
description	In recent years, the growth of urogenital infections, often transforming into chronic forms, is one of the most common causes of reproductive damage in women. The aim of the research was to study the structure of immune dysfunctions in patients with chronic urogenital infection. A one-stage observational study of 80 women of reproductive age with chronic urogenital infections was carried out. The control group consisted of 40 healthy women-donors. The main outcome of the study was the severity of the immunocomprometry of the female. The contents of different subpopulations of lymphocytes (CD3+, CD4+ and CD8+ T-lymphocytes, CD20+ B-), phagocytic activity of granulocytes and monocytes were determined, the migration index, the migration inhibition index, and the exponential function were calculated. The complex of immune dysfunctions established in such patients included a decrease in the number of T-cells and, primarily, CD4+ lymphocytes and their low mitogenic reactivity, an increase in the proportion of natural killer cells, a decrease in the number of actively phagocytic neutrophils and monocytes, the last hydrogen peroxide, an increase in the production of IgA and IgG. Typical were combinations of these violations. Conclusions: T-lymphocyte-monocyte immune deficitiency with the activation of the humoral link and the defectiveness of phagocytosis is a distinctive characteristic of chronic urogenital infection.
format	article
author	V. A. Kramarskiy V. S. Gorin A. I. Budaev Y. V. Trusov
author_facet	V. A. Kramarskiy V. S. Gorin A. I. Budaev Y. V. Trusov
author_sort	V. A. Kramarskiy
title	Structure of immune dysfunctions in patients with chronic urogenital infections
title_short	Structure of immune dysfunctions in patients with chronic urogenital infections
title_full	Structure of immune dysfunctions in patients with chronic urogenital infections
title_fullStr	Structure of immune dysfunctions in patients with chronic urogenital infections
title_full_unstemmed	Structure of immune dysfunctions in patients with chronic urogenital infections
title_sort	structure of immune dysfunctions in patients with chronic urogenital infections
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2018
url	https://doaj.org/article/ae49e7c9f4fc401a97a1316f8b8eb5e0
work_keys_str_mv	AT vakramarskiy structureofimmunedysfunctionsinpatientswithchronicurogenitalinfections AT vsgorin structureofimmunedysfunctionsinpatientswithchronicurogenitalinfections AT aibudaev structureofimmunedysfunctionsinpatientswithchronicurogenitalinfections AT yvtrusov structureofimmunedysfunctionsinpatientswithchronicurogenitalinfections
_version_	1718416968674967552

Structure of immune dysfunctions in patients with chronic urogenital infections

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